Effective colon cancer prophylaxis in mice using embryonic stem cells and carbon nanotubes

Teodora Mocan1, Cornel Iancu21Department of Physiology, 2Third Surgery Clinic, Department of Nanomedicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaIntroduction: In recent years, a new concept of an anticancer vaccine has been proposed to prevent and control the proli...

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Autores principales:	Mocan T, Iancu C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/42414183f4b643c0a9f524d6d51472fe
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spelling	oai:doaj.org-article:42414183f4b643c0a9f524d6d51472fe2021-12-02T08:08:30ZEffective colon cancer prophylaxis in mice using embryonic stem cells and carbon nanotubes1176-91141178-2013https://doaj.org/article/42414183f4b643c0a9f524d6d51472fe2011-09-01T00:00:00Zhttp://www.dovepress.com/effective-colon-cancer-prophylaxis-in-mice-using-embryonic-stem-cells--a8270https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Teodora Mocan1, Cornel Iancu21Department of Physiology, 2Third Surgery Clinic, Department of Nanomedicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaIntroduction: In recent years, a new concept of an anticancer vaccine has been proposed to prevent and control the proliferation and expansion of cancer cells by eliciting an immune boost in biological systems. The recent literature supports the role of embryonic stem cells (ESC) as cellular agents that stimulate the biological systems to destroy cancer cells. However, at present, a true anticancer vaccine remains elusive. There are several lines of evidence showing that carbon nanotubes may be used to initiate and maintain immune responses. Objective: The authors proposed to test the therapeutic potential of multiwalled carbon nanotubes (MWCNTs) combined with ESC as agents to induce an immune boost and provide subsequent anticancer protection in mice. Methods: C57 BL/6 mice were immunized with ESC and MWCNTs. Results: The proposed vaccine led to significant antitumor responses and enhanced tumor rejection in mice with subcutaneous inoculation of MC38 colon malign cells compared with groups only administered ESC, only MWCNTs, and controls. Conclusion: The application and potential of ESC combined with MWCNTs as anticancer immunization agents may represent the beginning of a new chapter in the treatment of colon cancer.Keywords: carbon nanotubes, embryonic stem cells, synergistic enhancement, immunization, colon cancer, vaccineMocan TIancu CDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 1945-1954 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Mocan T Iancu C Effective colon cancer prophylaxis in mice using embryonic stem cells and carbon nanotubes
description	Teodora Mocan1, Cornel Iancu21Department of Physiology, 2Third Surgery Clinic, Department of Nanomedicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaIntroduction: In recent years, a new concept of an anticancer vaccine has been proposed to prevent and control the proliferation and expansion of cancer cells by eliciting an immune boost in biological systems. The recent literature supports the role of embryonic stem cells (ESC) as cellular agents that stimulate the biological systems to destroy cancer cells. However, at present, a true anticancer vaccine remains elusive. There are several lines of evidence showing that carbon nanotubes may be used to initiate and maintain immune responses. Objective: The authors proposed to test the therapeutic potential of multiwalled carbon nanotubes (MWCNTs) combined with ESC as agents to induce an immune boost and provide subsequent anticancer protection in mice. Methods: C57 BL/6 mice were immunized with ESC and MWCNTs. Results: The proposed vaccine led to significant antitumor responses and enhanced tumor rejection in mice with subcutaneous inoculation of MC38 colon malign cells compared with groups only administered ESC, only MWCNTs, and controls. Conclusion: The application and potential of ESC combined with MWCNTs as anticancer immunization agents may represent the beginning of a new chapter in the treatment of colon cancer.Keywords: carbon nanotubes, embryonic stem cells, synergistic enhancement, immunization, colon cancer, vaccine
format	article
author	Mocan T Iancu C
author_facet	Mocan T Iancu C
author_sort	Mocan T
title	Effective colon cancer prophylaxis in mice using embryonic stem cells and carbon nanotubes
title_short	Effective colon cancer prophylaxis in mice using embryonic stem cells and carbon nanotubes
title_full	Effective colon cancer prophylaxis in mice using embryonic stem cells and carbon nanotubes
title_fullStr	Effective colon cancer prophylaxis in mice using embryonic stem cells and carbon nanotubes
title_full_unstemmed	Effective colon cancer prophylaxis in mice using embryonic stem cells and carbon nanotubes
title_sort	effective colon cancer prophylaxis in mice using embryonic stem cells and carbon nanotubes
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/42414183f4b643c0a9f524d6d51472fe
work_keys_str_mv	AT mocant effectivecoloncancerprophylaxisinmiceusingembryonicstemcellsandcarbonnanotubes AT iancuc effectivecoloncancerprophylaxisinmiceusingembryonicstemcellsandcarbonnanotubes
_version_	1718398596458479616

Effective colon cancer prophylaxis in mice using embryonic stem cells and carbon nanotubes

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