The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42

Cdc42 activity is important for apical-basal epithelial polarity. Here, the authors show that Shp2 disrupts Cdc42 activation, and by reducing the expression of histone deactylase 6, restores epithelial lumen formation in a cdc42-independent manner.

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Autores principales:	Sui-Chih Tien, Hsiao-Hui Lee, Ya-Chi Yang, Miao-Hsia Lin, Yu-Ju Chen, Zee-Fen Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4243125c42c74b088af92210cfcccd79
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spelling	oai:doaj.org-article:4243125c42c74b088af92210cfcccd792021-12-02T14:38:35ZThe Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc4210.1038/ncomms104202041-1723https://doaj.org/article/4243125c42c74b088af92210cfcccd792016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10420https://doaj.org/toc/2041-1723Cdc42 activity is important for apical-basal epithelial polarity. Here, the authors show that Shp2 disrupts Cdc42 activation, and by reducing the expression of histone deactylase 6, restores epithelial lumen formation in a cdc42-independent manner.Sui-Chih TienHsiao-Hui LeeYa-Chi YangMiao-Hsia LinYu-Ju ChenZee-Fen ChangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sui-Chih Tien Hsiao-Hui Lee Ya-Chi Yang Miao-Hsia Lin Yu-Ju Chen Zee-Fen Chang The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42
description	Cdc42 activity is important for apical-basal epithelial polarity. Here, the authors show that Shp2 disrupts Cdc42 activation, and by reducing the expression of histone deactylase 6, restores epithelial lumen formation in a cdc42-independent manner.
format	article
author	Sui-Chih Tien Hsiao-Hui Lee Ya-Chi Yang Miao-Hsia Lin Yu-Ju Chen Zee-Fen Chang
author_facet	Sui-Chih Tien Hsiao-Hui Lee Ya-Chi Yang Miao-Hsia Lin Yu-Ju Chen Zee-Fen Chang
author_sort	Sui-Chih Tien
title	The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42
title_short	The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42
title_full	The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42
title_fullStr	The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42
title_full_unstemmed	The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42
title_sort	shp2-induced epithelial disorganization defect is reversed by hdac6 inhibition independent of cdc42
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/4243125c42c74b088af92210cfcccd79
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The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42

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