Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4

The Lys48-linked polyubiquitin-mediated proteasomal degradation in yeast depends on Cdc48 and its cofactors Ufd1 and Npl4. Here, the authors present crystal structures of Npl4 bound to Lys48-linked diubiquitin and the Npl4-binding motif of Ufd1, providing insights into the reaction mechanism of the...

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Autores principales:	Yusuke Sato, Hikaru Tsuchiya, Atsushi Yamagata, Kei Okatsu, Keiji Tanaka, Yasushi Saeki, Shuya Fukai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4244723ac5d244baa41f569db4a6c956
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spelling	oai:doaj.org-article:4244723ac5d244baa41f569db4a6c9562021-12-02T15:35:32ZStructural insights into ubiquitin recognition and Ufd1 interaction of Npl410.1038/s41467-019-13697-y2041-1723https://doaj.org/article/4244723ac5d244baa41f569db4a6c9562019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13697-yhttps://doaj.org/toc/2041-1723The Lys48-linked polyubiquitin-mediated proteasomal degradation in yeast depends on Cdc48 and its cofactors Ufd1 and Npl4. Here, the authors present crystal structures of Npl4 bound to Lys48-linked diubiquitin and the Npl4-binding motif of Ufd1, providing insights into the reaction mechanism of the Cdc48- Ufd1/Npl4 complex.Yusuke SatoHikaru TsuchiyaAtsushi YamagataKei OkatsuKeiji TanakaYasushi SaekiShuya FukaiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yusuke Sato Hikaru Tsuchiya Atsushi Yamagata Kei Okatsu Keiji Tanaka Yasushi Saeki Shuya Fukai Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4
description	The Lys48-linked polyubiquitin-mediated proteasomal degradation in yeast depends on Cdc48 and its cofactors Ufd1 and Npl4. Here, the authors present crystal structures of Npl4 bound to Lys48-linked diubiquitin and the Npl4-binding motif of Ufd1, providing insights into the reaction mechanism of the Cdc48- Ufd1/Npl4 complex.
format	article
author	Yusuke Sato Hikaru Tsuchiya Atsushi Yamagata Kei Okatsu Keiji Tanaka Yasushi Saeki Shuya Fukai
author_facet	Yusuke Sato Hikaru Tsuchiya Atsushi Yamagata Kei Okatsu Keiji Tanaka Yasushi Saeki Shuya Fukai
author_sort	Yusuke Sato
title	Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4
title_short	Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4
title_full	Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4
title_fullStr	Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4
title_full_unstemmed	Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4
title_sort	structural insights into ubiquitin recognition and ufd1 interaction of npl4
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4244723ac5d244baa41f569db4a6c956
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Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4

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