Safety and effectiveness of kidney transplantation using a donation after brain death donor with acute kidney injury: a retrospective cohort study

Abstract The use of kidneys from donation after brain death (DBD) donors with acute kidney injury (AKI) is a strategy to expand the donor pool. The aim of this study was to evaluate how kidney transplantation (KT) from a donor with AKI affects long-term graft survival in various situations. All pati...

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Autores principales:	Kyeong Deok Kim, Kyo Won Lee, Sang Jin Kim, Okjoo Lee, Manuel Lim, Eun Sung Jeong, Jieun Kwon, Jaehun Yang, Jongwook Oh, Jae Berm Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/42472adc0d3d419b8acb4ae83f9cbfa0
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spelling	oai:doaj.org-article:42472adc0d3d419b8acb4ae83f9cbfa02021-12-02T11:35:41ZSafety and effectiveness of kidney transplantation using a donation after brain death donor with acute kidney injury: a retrospective cohort study10.1038/s41598-021-84977-12045-2322https://doaj.org/article/42472adc0d3d419b8acb4ae83f9cbfa02021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84977-1https://doaj.org/toc/2045-2322Abstract The use of kidneys from donation after brain death (DBD) donors with acute kidney injury (AKI) is a strategy to expand the donor pool. The aim of this study was to evaluate how kidney transplantation (KT) from a donor with AKI affects long-term graft survival in various situations. All patients who underwent KT from DBD donors between June 2003 and April 2016 were retrospectively reviewed. The KDIGO (Kidney Disease: Improving Global Outcomes) criteria were used to classify donor AKI. The cohort included 376 donors (no AKI group, n = 117 [31.1%]; AKI group n = 259 [68.9%]). Death-censored graft survival was similar according to the presence of AKI, AKI severity, and the AKI trend (p = 0.929, p = 0.077, and p = 0.658, respectively). Patients whose donors had AKI who received using low dose (1.5 mg/kg for three days) rabbit anti-thymocyte globulin (r-ATG) as the induction agent had significantly superior death-censored graft survival compared with patients in that group who received basiliximab (p = 0.039). AKI in DBD donors did not affect long-term death-censored graft survival. Low-dose r-ATG may be considered as an induction immunosuppression in recipients receiving kidneys with AKI because it showed better graft survival than basiliximab.Kyeong Deok KimKyo Won LeeSang Jin KimOkjoo LeeManuel LimEun Sung JeongJieun KwonJaehun YangJongwook OhJae Berm ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kyeong Deok Kim Kyo Won Lee Sang Jin Kim Okjoo Lee Manuel Lim Eun Sung Jeong Jieun Kwon Jaehun Yang Jongwook Oh Jae Berm Park Safety and effectiveness of kidney transplantation using a donation after brain death donor with acute kidney injury: a retrospective cohort study
description	Abstract The use of kidneys from donation after brain death (DBD) donors with acute kidney injury (AKI) is a strategy to expand the donor pool. The aim of this study was to evaluate how kidney transplantation (KT) from a donor with AKI affects long-term graft survival in various situations. All patients who underwent KT from DBD donors between June 2003 and April 2016 were retrospectively reviewed. The KDIGO (Kidney Disease: Improving Global Outcomes) criteria were used to classify donor AKI. The cohort included 376 donors (no AKI group, n = 117 [31.1%]; AKI group n = 259 [68.9%]). Death-censored graft survival was similar according to the presence of AKI, AKI severity, and the AKI trend (p = 0.929, p = 0.077, and p = 0.658, respectively). Patients whose donors had AKI who received using low dose (1.5 mg/kg for three days) rabbit anti-thymocyte globulin (r-ATG) as the induction agent had significantly superior death-censored graft survival compared with patients in that group who received basiliximab (p = 0.039). AKI in DBD donors did not affect long-term death-censored graft survival. Low-dose r-ATG may be considered as an induction immunosuppression in recipients receiving kidneys with AKI because it showed better graft survival than basiliximab.
format	article
author	Kyeong Deok Kim Kyo Won Lee Sang Jin Kim Okjoo Lee Manuel Lim Eun Sung Jeong Jieun Kwon Jaehun Yang Jongwook Oh Jae Berm Park
author_facet	Kyeong Deok Kim Kyo Won Lee Sang Jin Kim Okjoo Lee Manuel Lim Eun Sung Jeong Jieun Kwon Jaehun Yang Jongwook Oh Jae Berm Park
author_sort	Kyeong Deok Kim
title	Safety and effectiveness of kidney transplantation using a donation after brain death donor with acute kidney injury: a retrospective cohort study
title_short	Safety and effectiveness of kidney transplantation using a donation after brain death donor with acute kidney injury: a retrospective cohort study
title_full	Safety and effectiveness of kidney transplantation using a donation after brain death donor with acute kidney injury: a retrospective cohort study
title_fullStr	Safety and effectiveness of kidney transplantation using a donation after brain death donor with acute kidney injury: a retrospective cohort study
title_full_unstemmed	Safety and effectiveness of kidney transplantation using a donation after brain death donor with acute kidney injury: a retrospective cohort study
title_sort	safety and effectiveness of kidney transplantation using a donation after brain death donor with acute kidney injury: a retrospective cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/42472adc0d3d419b8acb4ae83f9cbfa0
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Safety and effectiveness of kidney transplantation using a donation after brain death donor with acute kidney injury: a retrospective cohort study

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