Cost-effective strategies for mitigating a future influenza pandemic with H1N1 2009 characteristics.

<h4>Background</h4>We performed an analysis of the cost-effectiveness of pandemic intervention strategies using a detailed, individual-based simulation model of a community in Australia together with health outcome data of infected individuals gathered during 2009-2010. The aim was to ex...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nilimesh Halder, Joel K Kelso, George J Milne
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4247cce6d5ae4a529ff01d5116733cea
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4247cce6d5ae4a529ff01d5116733cea
record_format	dspace
spelling	oai:doaj.org-article:4247cce6d5ae4a529ff01d5116733cea2021-12-02T20:11:45ZCost-effective strategies for mitigating a future influenza pandemic with H1N1 2009 characteristics.1932-620310.1371/journal.pone.0022087https://doaj.org/article/4247cce6d5ae4a529ff01d5116733cea2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21760957/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>We performed an analysis of the cost-effectiveness of pandemic intervention strategies using a detailed, individual-based simulation model of a community in Australia together with health outcome data of infected individuals gathered during 2009-2010. The aim was to examine the cost-effectiveness of a range of interventions to determine the most cost-effective strategies suitable for a future pandemic with H1N1 2009 characteristics.<h4>Methodology/principal findings</h4>Using transmissibility, age-stratified attack rates and health outcomes determined from H1N1 2009 data, we determined that the most cost-effective strategies involved treatment and household prophylaxis using antiviral drugs combined with limited duration school closure, with costs ranging from $632 to $777 per case prevented. When school closure was used as a sole intervention we found the use of limited duration school closure to be significantly more cost-effective compared to continuous school closure, a result with applicability to countries with limited access to antiviral drugs. Other social distancing strategies, such as reduced workplace attendance, were found to be costly due to productivity losses.<h4>Conclusion</h4>The mild severity (low hospitalisation and case fatality rates) and low transmissibility of H1N1 2009 meant that health treatment costs were dominated by the higher productivity losses arising from workplace absence due to illness and childcare requirements following school closure. Further analysis for higher transmissibility but with the same, mild severity had no effect on the overall findings.Nilimesh HalderJoel K KelsoGeorge J MilnePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e22087 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nilimesh Halder Joel K Kelso George J Milne Cost-effective strategies for mitigating a future influenza pandemic with H1N1 2009 characteristics.
description	<h4>Background</h4>We performed an analysis of the cost-effectiveness of pandemic intervention strategies using a detailed, individual-based simulation model of a community in Australia together with health outcome data of infected individuals gathered during 2009-2010. The aim was to examine the cost-effectiveness of a range of interventions to determine the most cost-effective strategies suitable for a future pandemic with H1N1 2009 characteristics.<h4>Methodology/principal findings</h4>Using transmissibility, age-stratified attack rates and health outcomes determined from H1N1 2009 data, we determined that the most cost-effective strategies involved treatment and household prophylaxis using antiviral drugs combined with limited duration school closure, with costs ranging from $632 to $777 per case prevented. When school closure was used as a sole intervention we found the use of limited duration school closure to be significantly more cost-effective compared to continuous school closure, a result with applicability to countries with limited access to antiviral drugs. Other social distancing strategies, such as reduced workplace attendance, were found to be costly due to productivity losses.<h4>Conclusion</h4>The mild severity (low hospitalisation and case fatality rates) and low transmissibility of H1N1 2009 meant that health treatment costs were dominated by the higher productivity losses arising from workplace absence due to illness and childcare requirements following school closure. Further analysis for higher transmissibility but with the same, mild severity had no effect on the overall findings.
format	article
author	Nilimesh Halder Joel K Kelso George J Milne
author_facet	Nilimesh Halder Joel K Kelso George J Milne
author_sort	Nilimesh Halder
title	Cost-effective strategies for mitigating a future influenza pandemic with H1N1 2009 characteristics.
title_short	Cost-effective strategies for mitigating a future influenza pandemic with H1N1 2009 characteristics.
title_full	Cost-effective strategies for mitigating a future influenza pandemic with H1N1 2009 characteristics.
title_fullStr	Cost-effective strategies for mitigating a future influenza pandemic with H1N1 2009 characteristics.
title_full_unstemmed	Cost-effective strategies for mitigating a future influenza pandemic with H1N1 2009 characteristics.
title_sort	cost-effective strategies for mitigating a future influenza pandemic with h1n1 2009 characteristics.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/4247cce6d5ae4a529ff01d5116733cea
work_keys_str_mv	AT nilimeshhalder costeffectivestrategiesformitigatingafutureinfluenzapandemicwithh1n12009characteristics AT joelkkelso costeffectivestrategiesformitigatingafutureinfluenzapandemicwithh1n12009characteristics AT georgejmilne costeffectivestrategiesformitigatingafutureinfluenzapandemicwithh1n12009characteristics
_version_	1718374879652216832

Cost-effective strategies for mitigating a future influenza pandemic with H1N1 2009 characteristics.

Ejemplares similares