Gray Matter Volume Correlates of Sleepiness: A Voxel-Based Morphometry Study in Younger and Older Adults

Torbjörn Åkerstedt,1,2 Mats Lekander,1,2 Gustav Nilsonne,1,2 Sandra Tamm,1,2 Paolo d’Onofrio,1,2 Göran Kecklund,1,2 Håkan Fischer,3 Johanna Schwarz,1,2 Predrag Petrovic,1 Kristoffer NT Månsson4– 6 1Department of Clinical Neuroscienc...

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Autores principales:	Åkerstedt T, Lekander M, Nilsonne G, Tamm S, d'Onofrio P, Kecklund G, Fischer H, Schwarz J, Petrovic P, Månsson KNT
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	brain imaging thalamus insula sleep kss Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/424827c7876247998ef4ba5b6de0203c
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spelling	oai:doaj.org-article:424827c7876247998ef4ba5b6de0203c2021-12-02T10:12:07ZGray Matter Volume Correlates of Sleepiness: A Voxel-Based Morphometry Study in Younger and Older Adults1179-1608https://doaj.org/article/424827c7876247998ef4ba5b6de0203c2020-05-01T00:00:00Zhttps://www.dovepress.com/gray-matter-volume-correlates-of-sleepiness-a-voxel-based-morphometry--peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Torbjörn Åkerstedt,1,2 Mats Lekander,1,2 Gustav Nilsonne,1,2 Sandra Tamm,1,2 Paolo d’Onofrio,1,2 Göran Kecklund,1,2 Håkan Fischer,3 Johanna Schwarz,1,2 Predrag Petrovic,1 Kristoffer NT Månsson4– 6 1Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; 2Stress Research Institute, Department of Psychology, Stockholm University, Stockholm, Sweden; 3Department of Psychology, Stockholm University, Stockholm, Sweden; 4Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; 5Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; 6Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, GermanyCorrespondence: Torbjörn ÅkerstedtDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm 17177, SwedenEmail torbjorn.akerstedt@ki.seBackground: Subjectively experienced sleepiness is a problem in society, possibly linked with gray matter (GM) volume. Given a different sleep pattern, aging may affect such associations, possibly due to shrinking brain volume.Purpose: The purpose of the present study was to investigate the association between subjectively rated sleepiness and GM volume in thalamus, insula, hippocampus, and orbitofrontal cortex of young and older adults, after a normal night’s sleep.Methods: Eighty-four healthy individuals participated (46 aged 20– 30 years, and 38 aged 65– 75 years). Morphological brain data were collected in a 3T magnetic resonance imaging (MRI) scanner. Sleepiness was rated multiple times during the imaging sessions.Results: In older, relative to younger, adults, clusters within bilateral mid-anterior insular cortex and right thalamus were negatively associated with sleepiness. Adjustment for the immediately preceding total sleep time eliminated the significant associations.Conclusion: Self-rated momentary sleepiness in a monotonous situation appears to be negatively associated with GM volume in clusters within both thalamus and insula in older individuals, and total sleep time seems to play a role in this association. Possibly, this suggests that larger GM volume in these clusters may be protective against sleepiness in older individuals. This notion needs confirmation in further studies.Keywords: brain imaging, thalamus, insula, sleep, KSSÅkerstedt TLekander MNilsonne GTamm Sd'Onofrio PKecklund GFischer HSchwarz JPetrovic PMånsson KNTDove Medical Pressarticlebrain imagingthalamusinsulasleepkssPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 12, Pp 289-298 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	brain imaging thalamus insula sleep kss Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	brain imaging thalamus insula sleep kss Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Åkerstedt T Lekander M Nilsonne G Tamm S d'Onofrio P Kecklund G Fischer H Schwarz J Petrovic P Månsson KNT Gray Matter Volume Correlates of Sleepiness: A Voxel-Based Morphometry Study in Younger and Older Adults
description	Torbjörn Åkerstedt,1,2 Mats Lekander,1,2 Gustav Nilsonne,1,2 Sandra Tamm,1,2 Paolo d’Onofrio,1,2 Göran Kecklund,1,2 Håkan Fischer,3 Johanna Schwarz,1,2 Predrag Petrovic,1 Kristoffer NT Månsson4– 6 1Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; 2Stress Research Institute, Department of Psychology, Stockholm University, Stockholm, Sweden; 3Department of Psychology, Stockholm University, Stockholm, Sweden; 4Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; 5Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; 6Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, GermanyCorrespondence: Torbjörn ÅkerstedtDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm 17177, SwedenEmail torbjorn.akerstedt@ki.seBackground: Subjectively experienced sleepiness is a problem in society, possibly linked with gray matter (GM) volume. Given a different sleep pattern, aging may affect such associations, possibly due to shrinking brain volume.Purpose: The purpose of the present study was to investigate the association between subjectively rated sleepiness and GM volume in thalamus, insula, hippocampus, and orbitofrontal cortex of young and older adults, after a normal night’s sleep.Methods: Eighty-four healthy individuals participated (46 aged 20– 30 years, and 38 aged 65– 75 years). Morphological brain data were collected in a 3T magnetic resonance imaging (MRI) scanner. Sleepiness was rated multiple times during the imaging sessions.Results: In older, relative to younger, adults, clusters within bilateral mid-anterior insular cortex and right thalamus were negatively associated with sleepiness. Adjustment for the immediately preceding total sleep time eliminated the significant associations.Conclusion: Self-rated momentary sleepiness in a monotonous situation appears to be negatively associated with GM volume in clusters within both thalamus and insula in older individuals, and total sleep time seems to play a role in this association. Possibly, this suggests that larger GM volume in these clusters may be protective against sleepiness in older individuals. This notion needs confirmation in further studies.Keywords: brain imaging, thalamus, insula, sleep, KSS
format	article
author	Åkerstedt T Lekander M Nilsonne G Tamm S d'Onofrio P Kecklund G Fischer H Schwarz J Petrovic P Månsson KNT
author_facet	Åkerstedt T Lekander M Nilsonne G Tamm S d'Onofrio P Kecklund G Fischer H Schwarz J Petrovic P Månsson KNT
author_sort	Åkerstedt T
title	Gray Matter Volume Correlates of Sleepiness: A Voxel-Based Morphometry Study in Younger and Older Adults
title_short	Gray Matter Volume Correlates of Sleepiness: A Voxel-Based Morphometry Study in Younger and Older Adults
title_full	Gray Matter Volume Correlates of Sleepiness: A Voxel-Based Morphometry Study in Younger and Older Adults
title_fullStr	Gray Matter Volume Correlates of Sleepiness: A Voxel-Based Morphometry Study in Younger and Older Adults
title_full_unstemmed	Gray Matter Volume Correlates of Sleepiness: A Voxel-Based Morphometry Study in Younger and Older Adults
title_sort	gray matter volume correlates of sleepiness: a voxel-based morphometry study in younger and older adults
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/424827c7876247998ef4ba5b6de0203c
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Gray Matter Volume Correlates of Sleepiness: A Voxel-Based Morphometry Study in Younger and Older Adults

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