$Genetic Landscape of Relapsed and Refractory Diffuse Large B-Cell Lymphoma: A Systemic Review and Association Analysis With Next-Generation Sequencing$
Código QR

Genetic Landscape of Relapsed and Refractory Diffuse Large B-Cell Lymphoma: A Systemic Review and Association Analysis With Next-Generation Sequencing

In our research, we screened 1,495 documents, compiled the whole-exome sequencing data of several studies, formed a data set including 92 observations of RRDLBCL (Relapsed and refractory diffuse large B-cell lymphoma), and performed association analysis on the high-frequency mutations among them. Th...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fan Gao, Lei Tian, Hui Shi, Peihao Zheng, Jing Wang, Fei Dong, Kai Hu, Xiaoyan Ke
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	diffuse large-cell lymphoma whole exome sequencing (WES) suppressor of cytokine signaling 1 protein (SOCS1) STAT6 transcription factor ITPKB protein Genetics QH426-470
Acceso en línea:	https://doaj.org/article/42484f9baa15469f8cb088a02512dd0c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:42484f9baa15469f8cb088a02512dd0c
record_format	dspace
spelling	oai:doaj.org-article:42484f9baa15469f8cb088a02512dd0c2021-12-02T11:17:21ZGenetic Landscape of Relapsed and Refractory Diffuse Large B-Cell Lymphoma: A Systemic Review and Association Analysis With Next-Generation Sequencing1664-802110.3389/fgene.2021.677650https://doaj.org/article/42484f9baa15469f8cb088a02512dd0c2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.677650/fullhttps://doaj.org/toc/1664-8021In our research, we screened 1,495 documents, compiled the whole-exome sequencing data of several studies, formed a data set including 92 observations of RRDLBCL (Relapsed and refractory diffuse large B-cell lymphoma), and performed association analysis on the high-frequency mutations among them. The most common mutations in the data set include TTN, KMT2D, TP53, IGLL5, CREBBP, BCL2, MYD88, and SOCS1 etc. Among these, CREBBP, KMT2D, and BCL2 have a strong association with each other, and SOCS1 has a strong association with genes such as STAT6, ACTB, CIITA, ITPKB, and GNA13. TP53 lacks significant associations with most genes. Through SOM clustering, expression-level analysis and protein interaction analysis of common gene mutations, we believe that RRDLBCL can be divided into five main types. We tested the function of the model and described the clinical characteristics of each subtype through a targeted sequencing RRDLBCL cohort of 96 patients. The classification is stated as follows: 1) JAK-STAT-related type: including STAT6, SOCS1, CIITA, etc. The genetic lineage is similar to PMBL and cHL. Retrospective analysis suggests that this subtype responds poorly to induction therapy (R-CHOP, p < 0.05). 2) BCL-CREBBP type: Epigenetic mutations such as KMT2D and CREBBP are more common in this type, and are often accompanied by BCL2 and EZH2 mutations. 3) MCD type: including MYD88 and CD79B, PIM1 is more common in this subtype. 4) TP53 mutation: TP53 mutant patients, which suggests the worst prognosis (p < 0.05) and worst response to CART treatment. 5) Undefined type (Sparse item type): Major Genetic Change Lacking Type, which has a better prognosis and better response to CART treatment. We also reviewed the literature from recent years concerning the previously mentioned common gene mutations.Fan GaoLei TianHui ShiPeihao ZhengJing WangFei DongKai HuXiaoyan KeFrontiers Media S.A.articlediffuse large-cell lymphomawhole exome sequencing (WES)suppressor of cytokine signaling 1 protein (SOCS1)STAT6 transcription factorITPKB proteinGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diffuse large-cell lymphoma whole exome sequencing (WES) suppressor of cytokine signaling 1 protein (SOCS1) STAT6 transcription factor ITPKB protein Genetics QH426-470
spellingShingle	diffuse large-cell lymphoma whole exome sequencing (WES) suppressor of cytokine signaling 1 protein (SOCS1) STAT6 transcription factor ITPKB protein Genetics QH426-470 Fan Gao Lei Tian Hui Shi Peihao Zheng Jing Wang Fei Dong Kai Hu Xiaoyan Ke Genetic Landscape of Relapsed and Refractory Diffuse Large B-Cell Lymphoma: A Systemic Review and Association Analysis With Next-Generation Sequencing
description	In our research, we screened 1,495 documents, compiled the whole-exome sequencing data of several studies, formed a data set including 92 observations of RRDLBCL (Relapsed and refractory diffuse large B-cell lymphoma), and performed association analysis on the high-frequency mutations among them. The most common mutations in the data set include TTN, KMT2D, TP53, IGLL5, CREBBP, BCL2, MYD88, and SOCS1 etc. Among these, CREBBP, KMT2D, and BCL2 have a strong association with each other, and SOCS1 has a strong association with genes such as STAT6, ACTB, CIITA, ITPKB, and GNA13. TP53 lacks significant associations with most genes. Through SOM clustering, expression-level analysis and protein interaction analysis of common gene mutations, we believe that RRDLBCL can be divided into five main types. We tested the function of the model and described the clinical characteristics of each subtype through a targeted sequencing RRDLBCL cohort of 96 patients. The classification is stated as follows: 1) JAK-STAT-related type: including STAT6, SOCS1, CIITA, etc. The genetic lineage is similar to PMBL and cHL. Retrospective analysis suggests that this subtype responds poorly to induction therapy (R-CHOP, p < 0.05). 2) BCL-CREBBP type: Epigenetic mutations such as KMT2D and CREBBP are more common in this type, and are often accompanied by BCL2 and EZH2 mutations. 3) MCD type: including MYD88 and CD79B, PIM1 is more common in this subtype. 4) TP53 mutation: TP53 mutant patients, which suggests the worst prognosis (p < 0.05) and worst response to CART treatment. 5) Undefined type (Sparse item type): Major Genetic Change Lacking Type, which has a better prognosis and better response to CART treatment. We also reviewed the literature from recent years concerning the previously mentioned common gene mutations.
format	article
author	Fan Gao Lei Tian Hui Shi Peihao Zheng Jing Wang Fei Dong Kai Hu Xiaoyan Ke
author_facet	Fan Gao Lei Tian Hui Shi Peihao Zheng Jing Wang Fei Dong Kai Hu Xiaoyan Ke
author_sort	Fan Gao
title	Genetic Landscape of Relapsed and Refractory Diffuse Large B-Cell Lymphoma: A Systemic Review and Association Analysis With Next-Generation Sequencing
title_short	Genetic Landscape of Relapsed and Refractory Diffuse Large B-Cell Lymphoma: A Systemic Review and Association Analysis With Next-Generation Sequencing
title_full	Genetic Landscape of Relapsed and Refractory Diffuse Large B-Cell Lymphoma: A Systemic Review and Association Analysis With Next-Generation Sequencing
title_fullStr	Genetic Landscape of Relapsed and Refractory Diffuse Large B-Cell Lymphoma: A Systemic Review and Association Analysis With Next-Generation Sequencing
title_full_unstemmed	Genetic Landscape of Relapsed and Refractory Diffuse Large B-Cell Lymphoma: A Systemic Review and Association Analysis With Next-Generation Sequencing
title_sort	genetic landscape of relapsed and refractory diffuse large b-cell lymphoma: a systemic review and association analysis with next-generation sequencing
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/42484f9baa15469f8cb088a02512dd0c
work_keys_str_mv	AT fangao geneticlandscapeofrelapsedandrefractorydiffuselargebcelllymphomaasystemicreviewandassociationanalysiswithnextgenerationsequencing AT leitian geneticlandscapeofrelapsedandrefractorydiffuselargebcelllymphomaasystemicreviewandassociationanalysiswithnextgenerationsequencing AT huishi geneticlandscapeofrelapsedandrefractorydiffuselargebcelllymphomaasystemicreviewandassociationanalysiswithnextgenerationsequencing AT peihaozheng geneticlandscapeofrelapsedandrefractorydiffuselargebcelllymphomaasystemicreviewandassociationanalysiswithnextgenerationsequencing AT jingwang geneticlandscapeofrelapsedandrefractorydiffuselargebcelllymphomaasystemicreviewandassociationanalysiswithnextgenerationsequencing AT feidong geneticlandscapeofrelapsedandrefractorydiffuselargebcelllymphomaasystemicreviewandassociationanalysiswithnextgenerationsequencing AT kaihu geneticlandscapeofrelapsedandrefractorydiffuselargebcelllymphomaasystemicreviewandassociationanalysiswithnextgenerationsequencing AT xiaoyanke geneticlandscapeofrelapsedandrefractorydiffuselargebcelllymphomaasystemicreviewandassociationanalysiswithnextgenerationsequencing
_version_	1718396044872515584

Genetic Landscape of Relapsed and Refractory Diffuse Large B-Cell Lymphoma: A Systemic Review and Association Analysis With Next-Generation Sequencing

Ejemplares similares