Canine cerebrospinal fluid total nucleated cell counts and cytology associations with the prevalence of magnetic resonance imaging abnormalities

Timothy B Hugo, Kathryn L Heading, Robert H Labuc Melbourne Veterinary Specialist Centre, Glen Waverley, Vic, Australia Introduction: The combination of cerebrospinal fluid (CSF) analysis and magnetic resonance imaging (MRI) are often used to investigate intracranial disease in dogs. The aim of th...

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Autores principales:	Hugo TB, Heading KL, Labuc RH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/4248d5e855414bca8271c9effe919f17
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spelling	oai:doaj.org-article:4248d5e855414bca8271c9effe919f172021-12-02T02:03:17ZCanine cerebrospinal fluid total nucleated cell counts and cytology associations with the prevalence of magnetic resonance imaging abnormalities2230-2034https://doaj.org/article/4248d5e855414bca8271c9effe919f172014-08-01T00:00:00Zhttp://www.dovepress.com/canine-cerebrospinal-fluid-total-nucleated-cell-counts-and-cytology-as-peer-reviewed-article-VMRRhttps://doaj.org/toc/2230-2034 Timothy B Hugo, Kathryn L Heading, Robert H Labuc Melbourne Veterinary Specialist Centre, Glen Waverley, Vic, Australia Introduction: The combination of cerebrospinal fluid (CSF) analysis and magnetic resonance imaging (MRI) are often used to investigate intracranial disease in dogs. The aim of this retrospective study was to determine if the total nucleated cell count (TNCC) or cytology findings in abnormal CSF are associated with the prevalence of MRI abnormalities. Materials and methods: For each case, the TNCC was categorized into one of three groups: A (<25×106/L); B (25–100×106/L); and C (>100×106/L). Cytology findings were categorized by the predominant cell type as lymphocytic, monocytoid, neutrophilic, or eosinopilic. MRI descriptions were classified as either normal or abnormal, and abnormal studies were further evaluated for the presence of specific characteristics (multifocal or diffuse disease versus focal disease, positive T2-weighted hyperintensity, positive FLAIR hyperintensity, contrast enhancement, mass effect, and the presence of poorly or well-defined lesion margins). Results: Forty-five dogs met the inclusion criteria and MRI abnormalities were found in 29/45 (64%) dogs. TNCCs were not associated with the prevalence of MRI abnormalities or specific characteristics. Cytology categories were significantly associated with the prevalence of MRI abnormalities (P<0.001). Specifically, monocytoid cytology was 22.8 times more likely to have an abnormal MRI than lymphocytic cytology. CSF cytology was not significantly associated with specific abnormal MRI characteristics. Conclusion: There are minimal associations between CSF abnormalities and the prevalence of MRI abnormalities. These results support the continued importance of utilizing both tests when investigating intracranial disease. When CSF analysis must be performed initially, this study has demonstrated that an abnormal CSF with a monocytoid cytology supports the value of performing a brain MRI in dogs with evidence of intracranial neurological disease. Keywords: cerebrospinal fluid, magnetic resonance imaging, canine, total nucleated cell counts, cytologyHugo TBHeading KLLabuc RHDove Medical PressarticleVeterinary medicineSF600-1100ENVeterinary Medicine: Research and Reports, Vol 2014, Iss default, Pp 75-84 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Veterinary medicine SF600-1100
spellingShingle	Veterinary medicine SF600-1100 Hugo TB Heading KL Labuc RH Canine cerebrospinal fluid total nucleated cell counts and cytology associations with the prevalence of magnetic resonance imaging abnormalities
description	Timothy B Hugo, Kathryn L Heading, Robert H Labuc Melbourne Veterinary Specialist Centre, Glen Waverley, Vic, Australia Introduction: The combination of cerebrospinal fluid (CSF) analysis and magnetic resonance imaging (MRI) are often used to investigate intracranial disease in dogs. The aim of this retrospective study was to determine if the total nucleated cell count (TNCC) or cytology findings in abnormal CSF are associated with the prevalence of MRI abnormalities. Materials and methods: For each case, the TNCC was categorized into one of three groups: A (<25×106/L); B (25–100×106/L); and C (>100×106/L). Cytology findings were categorized by the predominant cell type as lymphocytic, monocytoid, neutrophilic, or eosinopilic. MRI descriptions were classified as either normal or abnormal, and abnormal studies were further evaluated for the presence of specific characteristics (multifocal or diffuse disease versus focal disease, positive T2-weighted hyperintensity, positive FLAIR hyperintensity, contrast enhancement, mass effect, and the presence of poorly or well-defined lesion margins). Results: Forty-five dogs met the inclusion criteria and MRI abnormalities were found in 29/45 (64%) dogs. TNCCs were not associated with the prevalence of MRI abnormalities or specific characteristics. Cytology categories were significantly associated with the prevalence of MRI abnormalities (P<0.001). Specifically, monocytoid cytology was 22.8 times more likely to have an abnormal MRI than lymphocytic cytology. CSF cytology was not significantly associated with specific abnormal MRI characteristics. Conclusion: There are minimal associations between CSF abnormalities and the prevalence of MRI abnormalities. These results support the continued importance of utilizing both tests when investigating intracranial disease. When CSF analysis must be performed initially, this study has demonstrated that an abnormal CSF with a monocytoid cytology supports the value of performing a brain MRI in dogs with evidence of intracranial neurological disease. Keywords: cerebrospinal fluid, magnetic resonance imaging, canine, total nucleated cell counts, cytology
format	article
author	Hugo TB Heading KL Labuc RH
author_facet	Hugo TB Heading KL Labuc RH
author_sort	Hugo TB
title	Canine cerebrospinal fluid total nucleated cell counts and cytology associations with the prevalence of magnetic resonance imaging abnormalities
title_short	Canine cerebrospinal fluid total nucleated cell counts and cytology associations with the prevalence of magnetic resonance imaging abnormalities
title_full	Canine cerebrospinal fluid total nucleated cell counts and cytology associations with the prevalence of magnetic resonance imaging abnormalities
title_fullStr	Canine cerebrospinal fluid total nucleated cell counts and cytology associations with the prevalence of magnetic resonance imaging abnormalities
title_full_unstemmed	Canine cerebrospinal fluid total nucleated cell counts and cytology associations with the prevalence of magnetic resonance imaging abnormalities
title_sort	canine cerebrospinal fluid total nucleated cell counts and cytology associations with the prevalence of magnetic resonance imaging abnormalities
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/4248d5e855414bca8271c9effe919f17
work_keys_str_mv	AT hugotb caninecerebrospinalfluidtotalnucleatedcellcountsandcytologyassociationswiththeprevalenceofmagneticresonanceimagingabnormalities AT headingkl caninecerebrospinalfluidtotalnucleatedcellcountsandcytologyassociationswiththeprevalenceofmagneticresonanceimagingabnormalities AT labucrh caninecerebrospinalfluidtotalnucleatedcellcountsandcytologyassociationswiththeprevalenceofmagneticresonanceimagingabnormalities
_version_	1718402704908222464

Canine cerebrospinal fluid total nucleated cell counts and cytology associations with the prevalence of magnetic resonance imaging abnormalities

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