A cross-sectional investigation of SARS-CoV-2 seroprevalence and associated risk factors in children and adolescents in the United States.

<h4>Background</h4>Pediatric SARS-CoV-2 data remain limited and seropositivity rates in children were reported as <1% early in the pandemic. Seroepidemiologic evaluation of SARS-CoV-2 in children in a major metropolitan region of the US was performed.<h4>Methods</h4>Childr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rebecca E Levorson, Erica Christian, Brett Hunter, Jasdeep Sayal, Jiayang Sun, Scott A Bruce, Stephanie Garofalo, Matthew Southerland, Svetlana Ho, Shira Levy, Christopher Defillipi, Lilian Peake, Frederick C Place, Suchitra K Hourigan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/424bb9fa728a426e95994059fd133442
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:424bb9fa728a426e95994059fd133442
record_format	dspace
spelling	oai:doaj.org-article:424bb9fa728a426e95994059fd1334422021-12-02T20:16:24ZA cross-sectional investigation of SARS-CoV-2 seroprevalence and associated risk factors in children and adolescents in the United States.1932-620310.1371/journal.pone.0259823https://doaj.org/article/424bb9fa728a426e95994059fd1334422021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259823https://doaj.org/toc/1932-6203<h4>Background</h4>Pediatric SARS-CoV-2 data remain limited and seropositivity rates in children were reported as <1% early in the pandemic. Seroepidemiologic evaluation of SARS-CoV-2 in children in a major metropolitan region of the US was performed.<h4>Methods</h4>Children and adolescents ≤19 years were enrolled in a cross-sectional, observational study of SARS-CoV-2 seroprevalence from July-October 2020 in Northern Virginia, US. Demographic, health, and COVID-19 exposure information was collected, and blood analyzed for SARS-CoV-2 spike protein total antibody. Risk factors associated with SARS-CoV-2 seropositivity were analyzed. Orthogonal antibody testing was performed, and samples were evaluated for responses to different antigens.<h4>Results</h4>In 1038 children, the anti-SARS-CoV-2 total antibody positivity rate was 8.5%. After multivariate logistic regression, significant risk factors included Hispanic ethnicity, public or absent insurance, a history of COVID-19 symptoms, exposure to person with COVID-19, a household member positive for SARS-CoV-2 and multi-family or apartment dwelling without a private entrance. 66% of seropositive children had no symptoms of COVID-19. Secondary analysis included orthogonal antibody testing with assays for 1) a receptor binding domain specific antigen and 2) a nucleocapsid specific antigen had concordance rates of 80.5% and 79.3% respectively.<h4>Conclusions</h4>A much higher burden of SARS-CoV-2 infection, as determined by seropositivity, was found in children than previously reported; this was also higher compared to adults in the same region at a similar time. Contrary to prior reports, we determined children shoulder a significant burden of COVID-19 infection. The role of children's disease transmission must be considered in COVID-19 mitigation strategies including vaccination.Rebecca E LevorsonErica ChristianBrett HunterJasdeep SayalJiayang SunScott A BruceStephanie GarofaloMatthew SoutherlandSvetlana HoShira LevyChristopher DefillipiLilian PeakeFrederick C PlaceSuchitra K HouriganPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259823 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rebecca E Levorson Erica Christian Brett Hunter Jasdeep Sayal Jiayang Sun Scott A Bruce Stephanie Garofalo Matthew Southerland Svetlana Ho Shira Levy Christopher Defillipi Lilian Peake Frederick C Place Suchitra K Hourigan A cross-sectional investigation of SARS-CoV-2 seroprevalence and associated risk factors in children and adolescents in the United States.
description	<h4>Background</h4>Pediatric SARS-CoV-2 data remain limited and seropositivity rates in children were reported as <1% early in the pandemic. Seroepidemiologic evaluation of SARS-CoV-2 in children in a major metropolitan region of the US was performed.<h4>Methods</h4>Children and adolescents ≤19 years were enrolled in a cross-sectional, observational study of SARS-CoV-2 seroprevalence from July-October 2020 in Northern Virginia, US. Demographic, health, and COVID-19 exposure information was collected, and blood analyzed for SARS-CoV-2 spike protein total antibody. Risk factors associated with SARS-CoV-2 seropositivity were analyzed. Orthogonal antibody testing was performed, and samples were evaluated for responses to different antigens.<h4>Results</h4>In 1038 children, the anti-SARS-CoV-2 total antibody positivity rate was 8.5%. After multivariate logistic regression, significant risk factors included Hispanic ethnicity, public or absent insurance, a history of COVID-19 symptoms, exposure to person with COVID-19, a household member positive for SARS-CoV-2 and multi-family or apartment dwelling without a private entrance. 66% of seropositive children had no symptoms of COVID-19. Secondary analysis included orthogonal antibody testing with assays for 1) a receptor binding domain specific antigen and 2) a nucleocapsid specific antigen had concordance rates of 80.5% and 79.3% respectively.<h4>Conclusions</h4>A much higher burden of SARS-CoV-2 infection, as determined by seropositivity, was found in children than previously reported; this was also higher compared to adults in the same region at a similar time. Contrary to prior reports, we determined children shoulder a significant burden of COVID-19 infection. The role of children's disease transmission must be considered in COVID-19 mitigation strategies including vaccination.
format	article
author	Rebecca E Levorson Erica Christian Brett Hunter Jasdeep Sayal Jiayang Sun Scott A Bruce Stephanie Garofalo Matthew Southerland Svetlana Ho Shira Levy Christopher Defillipi Lilian Peake Frederick C Place Suchitra K Hourigan
author_facet	Rebecca E Levorson Erica Christian Brett Hunter Jasdeep Sayal Jiayang Sun Scott A Bruce Stephanie Garofalo Matthew Southerland Svetlana Ho Shira Levy Christopher Defillipi Lilian Peake Frederick C Place Suchitra K Hourigan
author_sort	Rebecca E Levorson
title	A cross-sectional investigation of SARS-CoV-2 seroprevalence and associated risk factors in children and adolescents in the United States.
title_short	A cross-sectional investigation of SARS-CoV-2 seroprevalence and associated risk factors in children and adolescents in the United States.
title_full	A cross-sectional investigation of SARS-CoV-2 seroprevalence and associated risk factors in children and adolescents in the United States.
title_fullStr	A cross-sectional investigation of SARS-CoV-2 seroprevalence and associated risk factors in children and adolescents in the United States.
title_full_unstemmed	A cross-sectional investigation of SARS-CoV-2 seroprevalence and associated risk factors in children and adolescents in the United States.
title_sort	cross-sectional investigation of sars-cov-2 seroprevalence and associated risk factors in children and adolescents in the united states.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/424bb9fa728a426e95994059fd133442
work_keys_str_mv	AT rebeccaelevorson acrosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT ericachristian acrosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT bretthunter acrosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT jasdeepsayal acrosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT jiayangsun acrosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT scottabruce acrosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT stephaniegarofalo acrosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT matthewsoutherland acrosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT svetlanaho acrosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT shiralevy acrosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT christopherdefillipi acrosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT lilianpeake acrosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT frederickcplace acrosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT suchitrakhourigan acrosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT rebeccaelevorson crosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT ericachristian crosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT bretthunter crosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT jasdeepsayal crosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT jiayangsun crosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT scottabruce crosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT stephaniegarofalo crosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT matthewsoutherland crosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT svetlanaho crosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT shiralevy crosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT christopherdefillipi crosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT lilianpeake crosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT frederickcplace crosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates AT suchitrakhourigan crosssectionalinvestigationofsarscov2seroprevalenceandassociatedriskfactorsinchildrenandadolescentsintheunitedstates
_version_	1718374465087209472

A cross-sectional investigation of SARS-CoV-2 seroprevalence and associated risk factors in children and adolescents in the United States.

Ejemplares similares