Cellgevity® attenuates liver distruption, oxidative stress and inflammation in STZ-diabetic male rats

The imbalance between reactive oxygen species (ROS) production and the innate antioxidant defence promotes oxidative distress and contributes to tissue dysfunctions which are the hallmark of diabetic complications. Diabetic hepatic injury is less reported, yet it is a target organ damage condition r...

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Autores principales:	Olugbenga Owolabi Ogunlabi, Bukunola Oluyemisi Adegbesan, Esther Nkechi Ezima, Adedayo Adebisi Adebisi
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	STZ-diabetes Liver function Hepatopathy Oxidative stress Inflammation Antioxidant enzymes Science Q
Acceso en línea:	https://doaj.org/article/424febe72fe74450b3196cee4d5f1f8f
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spelling	oai:doaj.org-article:424febe72fe74450b3196cee4d5f1f8f2021-11-28T04:36:04ZCellgevity® attenuates liver distruption, oxidative stress and inflammation in STZ-diabetic male rats2468-227610.1016/j.sciaf.2021.e01055https://doaj.org/article/424febe72fe74450b3196cee4d5f1f8f2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2468227621003562https://doaj.org/toc/2468-2276The imbalance between reactive oxygen species (ROS) production and the innate antioxidant defence promotes oxidative distress and contributes to tissue dysfunctions which are the hallmark of diabetic complications. Diabetic hepatic injury is less reported, yet it is a target organ damage condition related to diabetes. This study investigated the hepato-protective potentials of Cellgevity® in Streptozotocin (STZ)-diabetic male rats. The rats were assigned into – Control group and diabetes induced groups (DM-untreated, DM-treated 1 and DM-treated 2 groups respectively). Separate treatment of the DM-treated 1 and DM-treated 2 groups with therapeutic doses of Cellgevity® (25 mg/kg and 40 mg/kg BW respectively) was conducted for 30 days, while the control and DM-untreated groups receieved oral distilled water (placebo). The animals were then sacrificed and their sera were evaluated for total antioxidant status and biomarkers of hepatic function. The rats’ liver homogenates were also evaluated for inflammation, nitric oxide, lipid peroxidation and antioxidant enzymes activity. Treatment with Cellgevity® significantly increased the serum total antioxidant status (2 fold) and it reduced the serum ALT, AST, ALP and bilirubin levels compared to untreated diabetes by at least 1.4 fold. Hepatic activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) were significantly increased by over 130%, while liver TNF-α, nitrite and MDA levels were reduced by over 140% compared to the diabetic untreated group. The results present promising evidence for the therapeutic potential of Cellgevity® against diabetes-induced liver dysfunction, which might be through the modulation of ROS and inflammation production respectively.Olugbenga Owolabi OgunlabiBukunola Oluyemisi AdegbesanEsther Nkechi EzimaAdedayo Adebisi AdebisiElsevierarticleSTZ-diabetesLiver functionHepatopathyOxidative stressInflammationAntioxidant enzymesScienceQENScientific African, Vol 14, Iss , Pp e01055- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	STZ-diabetes Liver function Hepatopathy Oxidative stress Inflammation Antioxidant enzymes Science Q
spellingShingle	STZ-diabetes Liver function Hepatopathy Oxidative stress Inflammation Antioxidant enzymes Science Q Olugbenga Owolabi Ogunlabi Bukunola Oluyemisi Adegbesan Esther Nkechi Ezima Adedayo Adebisi Adebisi Cellgevity® attenuates liver distruption, oxidative stress and inflammation in STZ-diabetic male rats
description	The imbalance between reactive oxygen species (ROS) production and the innate antioxidant defence promotes oxidative distress and contributes to tissue dysfunctions which are the hallmark of diabetic complications. Diabetic hepatic injury is less reported, yet it is a target organ damage condition related to diabetes. This study investigated the hepato-protective potentials of Cellgevity® in Streptozotocin (STZ)-diabetic male rats. The rats were assigned into – Control group and diabetes induced groups (DM-untreated, DM-treated 1 and DM-treated 2 groups respectively). Separate treatment of the DM-treated 1 and DM-treated 2 groups with therapeutic doses of Cellgevity® (25 mg/kg and 40 mg/kg BW respectively) was conducted for 30 days, while the control and DM-untreated groups receieved oral distilled water (placebo). The animals were then sacrificed and their sera were evaluated for total antioxidant status and biomarkers of hepatic function. The rats’ liver homogenates were also evaluated for inflammation, nitric oxide, lipid peroxidation and antioxidant enzymes activity. Treatment with Cellgevity® significantly increased the serum total antioxidant status (2 fold) and it reduced the serum ALT, AST, ALP and bilirubin levels compared to untreated diabetes by at least 1.4 fold. Hepatic activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) were significantly increased by over 130%, while liver TNF-α, nitrite and MDA levels were reduced by over 140% compared to the diabetic untreated group. The results present promising evidence for the therapeutic potential of Cellgevity® against diabetes-induced liver dysfunction, which might be through the modulation of ROS and inflammation production respectively.
format	article
author	Olugbenga Owolabi Ogunlabi Bukunola Oluyemisi Adegbesan Esther Nkechi Ezima Adedayo Adebisi Adebisi
author_facet	Olugbenga Owolabi Ogunlabi Bukunola Oluyemisi Adegbesan Esther Nkechi Ezima Adedayo Adebisi Adebisi
author_sort	Olugbenga Owolabi Ogunlabi
title	Cellgevity® attenuates liver distruption, oxidative stress and inflammation in STZ-diabetic male rats
title_short	Cellgevity® attenuates liver distruption, oxidative stress and inflammation in STZ-diabetic male rats
title_full	Cellgevity® attenuates liver distruption, oxidative stress and inflammation in STZ-diabetic male rats
title_fullStr	Cellgevity® attenuates liver distruption, oxidative stress and inflammation in STZ-diabetic male rats
title_full_unstemmed	Cellgevity® attenuates liver distruption, oxidative stress and inflammation in STZ-diabetic male rats
title_sort	cellgevity® attenuates liver distruption, oxidative stress and inflammation in stz-diabetic male rats
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/424febe72fe74450b3196cee4d5f1f8f
work_keys_str_mv	AT olugbengaowolabiogunlabi cellgevityattenuatesliverdistruptionoxidativestressandinflammationinstzdiabeticmalerats AT bukunolaoluyemisiadegbesan cellgevityattenuatesliverdistruptionoxidativestressandinflammationinstzdiabeticmalerats AT esthernkechiezima cellgevityattenuatesliverdistruptionoxidativestressandinflammationinstzdiabeticmalerats AT adedayoadebisiadebisi cellgevityattenuatesliverdistruptionoxidativestressandinflammationinstzdiabeticmalerats
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Cellgevity® attenuates liver distruption, oxidative stress and inflammation in STZ-diabetic male rats

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