Anxiety and depression in patients with head and neck cancer: 6-month follow-up study

Yi-Shan Wu,1 Pao-Yen Lin,1,2 Chih-Yen Chien,3 Fu-Min Fang,4 Nien-Mu Chiu,1 Chi-Fa Hung,1 Yu Lee,1 Mian-Yoon Chong11Department of Psychiatry, 2Institute for Translational Research in Biomedical Sciences, 3Department of Otolaryngology, 4Department of Radiation Oncology, Kaohsiung Chang Gung Memorial H...

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Autores principales:	Wu YS, Lin PY, Chien CY, Fang FM, Chiu NM, Hung CF, Lee Y, Chong MY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	depression anxiety head and neck cancer functions lost Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/4255664cbdf346eba017934f731acd76
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spelling	oai:doaj.org-article:4255664cbdf346eba017934f731acd762021-12-02T07:45:34ZAnxiety and depression in patients with head and neck cancer: 6-month follow-up study1178-2021https://doaj.org/article/4255664cbdf346eba017934f731acd762016-04-01T00:00:00Zhttps://www.dovepress.com/anxiety-and-depression-in-patients-with-head-and-neck-cancer-6-month-f-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yi-Shan Wu,1 Pao-Yen Lin,1,2 Chih-Yen Chien,3 Fu-Min Fang,4 Nien-Mu Chiu,1 Chi-Fa Hung,1 Yu Lee,1 Mian-Yoon Chong11Department of Psychiatry, 2Institute for Translational Research in Biomedical Sciences, 3Department of Otolaryngology, 4Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, TaiwanObjective: We aimed to assess psychiatric morbidities of patients with head and neck cancer (HNC) in a prospective study at pretreatment, and 3 and 6 months after treatment, and to compare their health-related quality of life (HRQL) between those with and without depressive disorders (depression).Materials and methods: Patients with newly diagnosed HNC from a tertiary hospital were recruited into the study. They were assessed for psychiatric morbidities using the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, fourth edition. Their HRQL was simultaneously evaluated using the quality of life questionnaire of the European Organisation for Research and Treatment of Cancer with a specific module for head and neck cancer; and depressed and nondepressed HNC patients were compared by using the generalized mixed-effect model for repeated measurements.Results: A total of 106 patients were recruited into this study. High rates of anxiety were found at pretreatment, but steadily declined over time (from 27.3% to 6.4%, and later 3.3%). A skew pattern of depression was observed, with prevalence rates from 8.5% at pretreatment to 24.5% and 14% at 3 and 6 months, respectively, after treatment. We found that loss of sense (P=0.001), loss of speech (P<0.001), low libido (P=0.001), dry mouth (P<0.001), and weight loss (P=0.001) were related to depression over time. The depressed patients had a higher consumption of painkillers (P=0.001) and nutrition supplements (P<0.001). The results showed that depression was predicted by sticky saliva (P<0.001) and trouble with social contact (P<0.001) at 3 months, and trouble with social eating (P<0.001) at 6 months.Conclusion: Patients with HNC experienced different changes in anxiety and depression in the first 6 months of treatment. Dysfunction in salivation, problems with eating, and problems with social contacts were major risk factors for depression.Keywords: depression, anxiety, quality of lifeWu YSLin PYChien CYFang FMChiu NMHung CFLee YChong MYDove Medical Pressarticledepressionanxietyhead and neck cancerfunctions lostNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 1029-1036 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	depression anxiety head and neck cancer functions lost Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	depression anxiety head and neck cancer functions lost Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Wu YS Lin PY Chien CY Fang FM Chiu NM Hung CF Lee Y Chong MY Anxiety and depression in patients with head and neck cancer: 6-month follow-up study
description	Yi-Shan Wu,1 Pao-Yen Lin,1,2 Chih-Yen Chien,3 Fu-Min Fang,4 Nien-Mu Chiu,1 Chi-Fa Hung,1 Yu Lee,1 Mian-Yoon Chong11Department of Psychiatry, 2Institute for Translational Research in Biomedical Sciences, 3Department of Otolaryngology, 4Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, TaiwanObjective: We aimed to assess psychiatric morbidities of patients with head and neck cancer (HNC) in a prospective study at pretreatment, and 3 and 6 months after treatment, and to compare their health-related quality of life (HRQL) between those with and without depressive disorders (depression).Materials and methods: Patients with newly diagnosed HNC from a tertiary hospital were recruited into the study. They were assessed for psychiatric morbidities using the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, fourth edition. Their HRQL was simultaneously evaluated using the quality of life questionnaire of the European Organisation for Research and Treatment of Cancer with a specific module for head and neck cancer; and depressed and nondepressed HNC patients were compared by using the generalized mixed-effect model for repeated measurements.Results: A total of 106 patients were recruited into this study. High rates of anxiety were found at pretreatment, but steadily declined over time (from 27.3% to 6.4%, and later 3.3%). A skew pattern of depression was observed, with prevalence rates from 8.5% at pretreatment to 24.5% and 14% at 3 and 6 months, respectively, after treatment. We found that loss of sense (P=0.001), loss of speech (P<0.001), low libido (P=0.001), dry mouth (P<0.001), and weight loss (P=0.001) were related to depression over time. The depressed patients had a higher consumption of painkillers (P=0.001) and nutrition supplements (P<0.001). The results showed that depression was predicted by sticky saliva (P<0.001) and trouble with social contact (P<0.001) at 3 months, and trouble with social eating (P<0.001) at 6 months.Conclusion: Patients with HNC experienced different changes in anxiety and depression in the first 6 months of treatment. Dysfunction in salivation, problems with eating, and problems with social contacts were major risk factors for depression.Keywords: depression, anxiety, quality of life
format	article
author	Wu YS Lin PY Chien CY Fang FM Chiu NM Hung CF Lee Y Chong MY
author_facet	Wu YS Lin PY Chien CY Fang FM Chiu NM Hung CF Lee Y Chong MY
author_sort	Wu YS
title	Anxiety and depression in patients with head and neck cancer: 6-month follow-up study
title_short	Anxiety and depression in patients with head and neck cancer: 6-month follow-up study
title_full	Anxiety and depression in patients with head and neck cancer: 6-month follow-up study
title_fullStr	Anxiety and depression in patients with head and neck cancer: 6-month follow-up study
title_full_unstemmed	Anxiety and depression in patients with head and neck cancer: 6-month follow-up study
title_sort	anxiety and depression in patients with head and neck cancer: 6-month follow-up study
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/4255664cbdf346eba017934f731acd76
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Anxiety and depression in patients with head and neck cancer: 6-month follow-up study

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