The effects of graphene and mesenchymal stem cells in cutaneous wound healing and their putative action mechanism
Iwona Lasocka,1 Elżbieta Jastrzębska,2 Lidia Szulc-Dąbrowska,3 Michał Skibniewski,4 Iwona Pasternak,5 Marie Hubalek Kalbacova,6,7 Ewa M Skibniewska1 1Department of Animal Environment Biology, Faculty of Animal Science, Warsaw University of Life Sciences, Warsaw, Poland; 2Department of Medical Biote...
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| Autores principales: | , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2019
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| Acceso en línea: | https://doaj.org/article/425734dee9bf4f75a9fe2134e138dc11 |
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| Sumario: | Iwona Lasocka,1 Elżbieta Jastrzębska,2 Lidia Szulc-Dąbrowska,3 Michał Skibniewski,4 Iwona Pasternak,5 Marie Hubalek Kalbacova,6,7 Ewa M Skibniewska1 1Department of Animal Environment Biology, Faculty of Animal Science, Warsaw University of Life Sciences, Warsaw, Poland; 2Department of Medical Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Warsaw, Poland; 3Department of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland; 4Department of Morphological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland; 5Faculty of Physics, Warsaw University of Technology, Warsaw, Poland; 6Institute of Pathological Physiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic; 7Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic Abstract: This study provides a review of the therapeutic potential of graphene dressing scaffolds and mesenchymal stem cells (MSCs) and their synergistic effects with respect to cutaneous wound healing. This study also considers their putative action mechanism based on the antibacterial, immunomodulating, angiogenic, matrix remodeling effects of materials belonging to the graphene family and MSCs during the wound healing process. In addition, this study discusses the cytocompatibility of graphene, its uses as a platform for skin substitutes, the properties it possesses with respect to providing protection against microbial invasion as well as strategies aimed at minimizing the chance of the occurrence of sepsis. MSCs are capable of secreting several factors that exert a therapeutic impact on reparative processes and tissue regeneration. In light of experiments conducted to date, graphene combined with MSCs appears to have the potential to enhance both the wound healing process and infection control at the injury site. Keywords: graphene, mesenchymal stem cells, wound, healing |
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