The effects of graphene and mesenchymal stem cells in cutaneous wound healing and their putative action mechanism

Iwona Lasocka,1 Elżbieta Jastrzębska,2 Lidia Szulc-Dąbrowska,3 Michał Skibniewski,4 Iwona Pasternak,5 Marie Hubalek Kalbacova,6,7 Ewa M Skibniewska1 1Department of Animal Environment Biology, Faculty of Animal Science, Warsaw University of Life Sciences, Warsaw, Poland; 2Department of Medical Biote...

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Autores principales:	Lasocka I, Jastrzębska E, Szulc-Dąbrowska L, Skibniewski M, Pasternak I, Hubalek Kalbacova M, Skibniewska EM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Graphene mesenchymal stem cells wound healing Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/425734dee9bf4f75a9fe2134e138dc11
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spelling	oai:doaj.org-article:425734dee9bf4f75a9fe2134e138dc112021-12-02T04:24:27ZThe effects of graphene and mesenchymal stem cells in cutaneous wound healing and their putative action mechanism1178-2013https://doaj.org/article/425734dee9bf4f75a9fe2134e138dc112019-04-01T00:00:00Zhttps://www.dovepress.com/the-effects-of-graphene-and-mesenchymal-stem-cells-in-cutaneous-wound--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Iwona Lasocka,1 Elżbieta Jastrzębska,2 Lidia Szulc-Dąbrowska,3 Michał Skibniewski,4 Iwona Pasternak,5 Marie Hubalek Kalbacova,6,7 Ewa M Skibniewska1 1Department of Animal Environment Biology, Faculty of Animal Science, Warsaw University of Life Sciences, Warsaw, Poland; 2Department of Medical Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Warsaw, Poland; 3Department of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland; 4Department of Morphological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland; 5Faculty of Physics, Warsaw University of Technology, Warsaw, Poland; 6Institute of Pathological Physiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic; 7Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic Abstract: This study provides a review of the therapeutic potential of graphene dressing scaffolds and mesenchymal stem cells (MSCs) and their synergistic effects with respect to cutaneous wound healing. This study also considers their putative action mechanism based on the antibacterial, immunomodulating, angiogenic, matrix remodeling effects of materials belonging to the graphene family and MSCs during the wound healing process. In addition, this study discusses the cytocompatibility of graphene, its uses as a platform for skin substitutes, the properties it possesses with respect to providing protection against microbial invasion as well as strategies aimed at minimizing the chance of the occurrence of sepsis. MSCs are capable of secreting several factors that exert a therapeutic impact on reparative processes and tissue regeneration. In light of experiments conducted to date, graphene combined with MSCs appears to have the potential to enhance both the wound healing process and infection control at the injury site. Keywords: graphene, mesenchymal stem cells, wound, healingLasocka IJastrzębska ESzulc-Dąbrowska LSkibniewski MPasternak IHubalek Kalbacova MSkibniewska EMDove Medical PressarticleGraphenemesenchymal stem cellswoundhealingMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 2281-2299 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Graphene mesenchymal stem cells wound healing Medicine (General) R5-920
spellingShingle	Graphene mesenchymal stem cells wound healing Medicine (General) R5-920 Lasocka I Jastrzębska E Szulc-Dąbrowska L Skibniewski M Pasternak I Hubalek Kalbacova M Skibniewska EM The effects of graphene and mesenchymal stem cells in cutaneous wound healing and their putative action mechanism
description	Iwona Lasocka,1 Elżbieta Jastrzębska,2 Lidia Szulc-Dąbrowska,3 Michał Skibniewski,4 Iwona Pasternak,5 Marie Hubalek Kalbacova,6,7 Ewa M Skibniewska1 1Department of Animal Environment Biology, Faculty of Animal Science, Warsaw University of Life Sciences, Warsaw, Poland; 2Department of Medical Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Warsaw, Poland; 3Department of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland; 4Department of Morphological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland; 5Faculty of Physics, Warsaw University of Technology, Warsaw, Poland; 6Institute of Pathological Physiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic; 7Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic Abstract: This study provides a review of the therapeutic potential of graphene dressing scaffolds and mesenchymal stem cells (MSCs) and their synergistic effects with respect to cutaneous wound healing. This study also considers their putative action mechanism based on the antibacterial, immunomodulating, angiogenic, matrix remodeling effects of materials belonging to the graphene family and MSCs during the wound healing process. In addition, this study discusses the cytocompatibility of graphene, its uses as a platform for skin substitutes, the properties it possesses with respect to providing protection against microbial invasion as well as strategies aimed at minimizing the chance of the occurrence of sepsis. MSCs are capable of secreting several factors that exert a therapeutic impact on reparative processes and tissue regeneration. In light of experiments conducted to date, graphene combined with MSCs appears to have the potential to enhance both the wound healing process and infection control at the injury site. Keywords: graphene, mesenchymal stem cells, wound, healing
format	article
author	Lasocka I Jastrzębska E Szulc-Dąbrowska L Skibniewski M Pasternak I Hubalek Kalbacova M Skibniewska EM
author_facet	Lasocka I Jastrzębska E Szulc-Dąbrowska L Skibniewski M Pasternak I Hubalek Kalbacova M Skibniewska EM
author_sort	Lasocka I
title	The effects of graphene and mesenchymal stem cells in cutaneous wound healing and their putative action mechanism
title_short	The effects of graphene and mesenchymal stem cells in cutaneous wound healing and their putative action mechanism
title_full	The effects of graphene and mesenchymal stem cells in cutaneous wound healing and their putative action mechanism
title_fullStr	The effects of graphene and mesenchymal stem cells in cutaneous wound healing and their putative action mechanism
title_full_unstemmed	The effects of graphene and mesenchymal stem cells in cutaneous wound healing and their putative action mechanism
title_sort	effects of graphene and mesenchymal stem cells in cutaneous wound healing and their putative action mechanism
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/425734dee9bf4f75a9fe2134e138dc11
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The effects of graphene and mesenchymal stem cells in cutaneous wound healing and their putative action mechanism

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