Potential causes of the preoperative increase in the rectosigmoid cyclic motor pattern: A high‐resolution manometry study

Abstract Background Cyclic motor patterns (CMPs) are the most common motor pattern in the distal colon. This study used high‐resolution (HR) colonic manometry to quantify trends in distal colonic motor activity before elective colonic surgery, determine the effect of a preoperative carbohydrate load...

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Autores principales:	Cameron I. Wells, Sameer Bhat, Nira Paskaranandavadivel, Anthony Y. Lin, Ryash Vather, Chris Varghese, James A. Penfold, David Rowbotham, Phil G. Dinning, Ian P. Bissett, Greg O’Grady
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	colonic manometry motility oral carbohydrate preoperative Physiology QP1-981
Acceso en línea:	https://doaj.org/article/42581fc5bfdd49f795f3d4731eb267ca
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spelling	oai:doaj.org-article:42581fc5bfdd49f795f3d4731eb267ca2021-11-27T15:48:30ZPotential causes of the preoperative increase in the rectosigmoid cyclic motor pattern: A high‐resolution manometry study2051-817X10.14814/phy2.15091https://doaj.org/article/42581fc5bfdd49f795f3d4731eb267ca2021-11-01T00:00:00Zhttps://doi.org/10.14814/phy2.15091https://doaj.org/toc/2051-817XAbstract Background Cyclic motor patterns (CMPs) are the most common motor pattern in the distal colon. This study used high‐resolution (HR) colonic manometry to quantify trends in distal colonic motor activity before elective colonic surgery, determine the effect of a preoperative carbohydrate load, and compare this with a meal response in healthy controls. Methods Fiber‐optic HR colonic manometry (36 sensors, 1 cm intervals) was used to investigate distal colonic motor activity in 10 adult patients prior to elective colonic surgery, 6 of whom consumed a preoperative carbohydrate drink (200 kCal). Data were compared with nine healthy volunteers who underwent HR colonic manometry recordings while fasted and following a 700 kCal meal. The primary outcome was the percentage of recording occupied by CMPs, defined as propagating contractions at 2–4 cycles per minute (cpm). Secondary outcomes included amplitude, speed, and distance of propagating motor patterns. Results The occurrence of CMPs progressively increased in time periods closer to surgery (p = 0.001). Consumption of a preoperative drink resulted in significantly increased CMP occurrence (p = 0.04) and propagating distance (p = 0.04). There were no changes in amplitude or speed of propagating motor patterns during the preoperative period. The increase in activity following a preoperative drink was of similar magnitude to the colonic meal response observed in healthy controls, despite the lesser caloric nutrient load. Conclusion Distal colonic CMP increased in occurrence prior to surgery, amplified by ingestion of preoperative carbohydrate drinks. We hypothesize that anxiety, which is also known to rise with proximity to surgery, could play a contributing role.Cameron I. WellsSameer BhatNira PaskaranandavadivelAnthony Y. LinRyash VatherChris VargheseJames A. PenfoldDavid RowbothamPhil G. DinningIan P. BissettGreg O’GradyWileyarticlecolonic manometrymotilityoral carbohydratepreoperativePhysiologyQP1-981ENPhysiological Reports, Vol 9, Iss 22, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colonic manometry motility oral carbohydrate preoperative Physiology QP1-981
spellingShingle	colonic manometry motility oral carbohydrate preoperative Physiology QP1-981 Cameron I. Wells Sameer Bhat Nira Paskaranandavadivel Anthony Y. Lin Ryash Vather Chris Varghese James A. Penfold David Rowbotham Phil G. Dinning Ian P. Bissett Greg O’Grady Potential causes of the preoperative increase in the rectosigmoid cyclic motor pattern: A high‐resolution manometry study
description	Abstract Background Cyclic motor patterns (CMPs) are the most common motor pattern in the distal colon. This study used high‐resolution (HR) colonic manometry to quantify trends in distal colonic motor activity before elective colonic surgery, determine the effect of a preoperative carbohydrate load, and compare this with a meal response in healthy controls. Methods Fiber‐optic HR colonic manometry (36 sensors, 1 cm intervals) was used to investigate distal colonic motor activity in 10 adult patients prior to elective colonic surgery, 6 of whom consumed a preoperative carbohydrate drink (200 kCal). Data were compared with nine healthy volunteers who underwent HR colonic manometry recordings while fasted and following a 700 kCal meal. The primary outcome was the percentage of recording occupied by CMPs, defined as propagating contractions at 2–4 cycles per minute (cpm). Secondary outcomes included amplitude, speed, and distance of propagating motor patterns. Results The occurrence of CMPs progressively increased in time periods closer to surgery (p = 0.001). Consumption of a preoperative drink resulted in significantly increased CMP occurrence (p = 0.04) and propagating distance (p = 0.04). There were no changes in amplitude or speed of propagating motor patterns during the preoperative period. The increase in activity following a preoperative drink was of similar magnitude to the colonic meal response observed in healthy controls, despite the lesser caloric nutrient load. Conclusion Distal colonic CMP increased in occurrence prior to surgery, amplified by ingestion of preoperative carbohydrate drinks. We hypothesize that anxiety, which is also known to rise with proximity to surgery, could play a contributing role.
format	article
author	Cameron I. Wells Sameer Bhat Nira Paskaranandavadivel Anthony Y. Lin Ryash Vather Chris Varghese James A. Penfold David Rowbotham Phil G. Dinning Ian P. Bissett Greg O’Grady
author_facet	Cameron I. Wells Sameer Bhat Nira Paskaranandavadivel Anthony Y. Lin Ryash Vather Chris Varghese James A. Penfold David Rowbotham Phil G. Dinning Ian P. Bissett Greg O’Grady
author_sort	Cameron I. Wells
title	Potential causes of the preoperative increase in the rectosigmoid cyclic motor pattern: A high‐resolution manometry study
title_short	Potential causes of the preoperative increase in the rectosigmoid cyclic motor pattern: A high‐resolution manometry study
title_full	Potential causes of the preoperative increase in the rectosigmoid cyclic motor pattern: A high‐resolution manometry study
title_fullStr	Potential causes of the preoperative increase in the rectosigmoid cyclic motor pattern: A high‐resolution manometry study
title_full_unstemmed	Potential causes of the preoperative increase in the rectosigmoid cyclic motor pattern: A high‐resolution manometry study
title_sort	potential causes of the preoperative increase in the rectosigmoid cyclic motor pattern: a high‐resolution manometry study
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/42581fc5bfdd49f795f3d4731eb267ca
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Potential causes of the preoperative increase in the rectosigmoid cyclic motor pattern: A high‐resolution manometry study

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