Association between glycated hemoglobin (HbA1c) and the lipid profile in patients with type 2 diabetes mellitus at a tertiary care hospital: a retrospective study

Sami Hamdan Alzahrani,1 Mukhtiar Baig,2 Mooataz Mohammed Aashi,3 Faisal Khaled Al-shaibi,4 Dalya Abdulrahman Alqarni,4 Wael Hassan Bakhamees41Family Medicine Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of Clinical Biochemistry, Faculty of Medicine, R...

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Autores principales:	Alzahrani SH, Baig M, Aashi MM, Al-shaibi FK, Alqarni DA, Bakhamees WH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Glycated hemoglobin DMT2 Glycemic control Dyslipidemia Lipid profile Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/4258af6838724b9dbcd7aabc1aba36d4
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spelling	oai:doaj.org-article:4258af6838724b9dbcd7aabc1aba36d42021-12-02T04:08:15ZAssociation between glycated hemoglobin (HbA1c) and the lipid profile in patients with type 2 diabetes mellitus at a tertiary care hospital: a retrospective study1178-7007https://doaj.org/article/4258af6838724b9dbcd7aabc1aba36d42019-08-01T00:00:00Zhttps://www.dovepress.com/association-between-glycated-hemoglobin-hba1c-and-the-lipid-profile-in-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Sami Hamdan Alzahrani,1 Mukhtiar Baig,2 Mooataz Mohammed Aashi,3 Faisal Khaled Al-shaibi,4 Dalya Abdulrahman Alqarni,4 Wael Hassan Bakhamees41Family Medicine Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of Clinical Biochemistry, Faculty of Medicine, Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia; 3Pediatric Department, King Abdulaziz University Hospital, Jeddah, Saudi Arabia; 4Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi ArabiaCorrespondence: Sami Hamdan AlzahraniFamily Medicine Department, Faculty of Medicine, King Abdulaziz University, P.O. Box 4828, Jeddah 22431, Saudi ArabiaTel +966 950 000 4062Email drsamihz@gmail.comBackground: To investigate the association between glycated hemoglobin (HbA1c) and the lipid profile in patients with type 2 diabetes mellitus (T2DM) at a tertiary care hospital in Jeddah, Saudi Arabia (SA).Methods: The present retrospective cross-sectional study was accomplished at the Faculty of Medicine, King Abdulaziz University (KAU), Jeddah, SA, between April and July 2018. There were 206 T2DM patients selected for the study (141 females and 65 males), and the data were collected through a review of the electronic profiles of patients by using the medical electronic file system used at the KAU Hospital. Biochemical data such as fasting plasma glucose (FPG), HbA1c and lipid profile, along with the patient’s age, BMI and gender, were also taken from the electronic file system. The inclusion criteria allowed for only patients who were regularly seeing their physician and whose electronic file was up to date.Results: The participants’ data were analyzed gender-wise. The females had significantly higher values for BMI (p=0.002), HbA1c (p=0.009), triglycerides (TGs) (p<0.001), high-density lipoprotein cholesterol (HDL-C) (p=0.002) and low-density lipoprotein cholesterol (LDL-C) (p<0.001) compared to the males. The study subjects were grouped according to their level of HbA1c (good glycemic index <7%, and poor glycemic index >7%). In both groups, no significant differences were found in any of the parameters other than TGs (p=0.020) and HbA1c (p<0.001). An analysis of the correlation between HbA1c and other parameters exhibited a significant correlation with TG (r=0.16, p=0.020), while no significant relationship was observed with the other variables. The linear regression results indicated that HbA1c values were associated with TGs (p=0.020) and were independent of age, BMI, TC, LDL-C, HDL-C and FPG levels.Conclusion: The glycated Hb was associated with TGs, and no significant association was found with age, BMI, TC, LDL-C, HDL-C and FPG levels.Keywords: glycated hemoglobin, DMT2, glycemic control, dyslipidemia, lipid profileAlzahrani SHBaig MAashi MMAl-shaibi FKAlqarni DABakhamees WHDove Medical PressarticleGlycated hemoglobinDMT2Glycemic controlDyslipidemiaLipid profileSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 1639-1644 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Glycated hemoglobin DMT2 Glycemic control Dyslipidemia Lipid profile Specialties of internal medicine RC581-951
spellingShingle	Glycated hemoglobin DMT2 Glycemic control Dyslipidemia Lipid profile Specialties of internal medicine RC581-951 Alzahrani SH Baig M Aashi MM Al-shaibi FK Alqarni DA Bakhamees WH Association between glycated hemoglobin (HbA1c) and the lipid profile in patients with type 2 diabetes mellitus at a tertiary care hospital: a retrospective study
description	Sami Hamdan Alzahrani,1 Mukhtiar Baig,2 Mooataz Mohammed Aashi,3 Faisal Khaled Al-shaibi,4 Dalya Abdulrahman Alqarni,4 Wael Hassan Bakhamees41Family Medicine Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of Clinical Biochemistry, Faculty of Medicine, Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia; 3Pediatric Department, King Abdulaziz University Hospital, Jeddah, Saudi Arabia; 4Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi ArabiaCorrespondence: Sami Hamdan AlzahraniFamily Medicine Department, Faculty of Medicine, King Abdulaziz University, P.O. Box 4828, Jeddah 22431, Saudi ArabiaTel +966 950 000 4062Email drsamihz@gmail.comBackground: To investigate the association between glycated hemoglobin (HbA1c) and the lipid profile in patients with type 2 diabetes mellitus (T2DM) at a tertiary care hospital in Jeddah, Saudi Arabia (SA).Methods: The present retrospective cross-sectional study was accomplished at the Faculty of Medicine, King Abdulaziz University (KAU), Jeddah, SA, between April and July 2018. There were 206 T2DM patients selected for the study (141 females and 65 males), and the data were collected through a review of the electronic profiles of patients by using the medical electronic file system used at the KAU Hospital. Biochemical data such as fasting plasma glucose (FPG), HbA1c and lipid profile, along with the patient’s age, BMI and gender, were also taken from the electronic file system. The inclusion criteria allowed for only patients who were regularly seeing their physician and whose electronic file was up to date.Results: The participants’ data were analyzed gender-wise. The females had significantly higher values for BMI (p=0.002), HbA1c (p=0.009), triglycerides (TGs) (p<0.001), high-density lipoprotein cholesterol (HDL-C) (p=0.002) and low-density lipoprotein cholesterol (LDL-C) (p<0.001) compared to the males. The study subjects were grouped according to their level of HbA1c (good glycemic index <7%, and poor glycemic index >7%). In both groups, no significant differences were found in any of the parameters other than TGs (p=0.020) and HbA1c (p<0.001). An analysis of the correlation between HbA1c and other parameters exhibited a significant correlation with TG (r=0.16, p=0.020), while no significant relationship was observed with the other variables. The linear regression results indicated that HbA1c values were associated with TGs (p=0.020) and were independent of age, BMI, TC, LDL-C, HDL-C and FPG levels.Conclusion: The glycated Hb was associated with TGs, and no significant association was found with age, BMI, TC, LDL-C, HDL-C and FPG levels.Keywords: glycated hemoglobin, DMT2, glycemic control, dyslipidemia, lipid profile
format	article
author	Alzahrani SH Baig M Aashi MM Al-shaibi FK Alqarni DA Bakhamees WH
author_facet	Alzahrani SH Baig M Aashi MM Al-shaibi FK Alqarni DA Bakhamees WH
author_sort	Alzahrani SH
title	Association between glycated hemoglobin (HbA1c) and the lipid profile in patients with type 2 diabetes mellitus at a tertiary care hospital: a retrospective study
title_short	Association between glycated hemoglobin (HbA1c) and the lipid profile in patients with type 2 diabetes mellitus at a tertiary care hospital: a retrospective study
title_full	Association between glycated hemoglobin (HbA1c) and the lipid profile in patients with type 2 diabetes mellitus at a tertiary care hospital: a retrospective study
title_fullStr	Association between glycated hemoglobin (HbA1c) and the lipid profile in patients with type 2 diabetes mellitus at a tertiary care hospital: a retrospective study
title_full_unstemmed	Association between glycated hemoglobin (HbA1c) and the lipid profile in patients with type 2 diabetes mellitus at a tertiary care hospital: a retrospective study
title_sort	association between glycated hemoglobin (hba1c) and the lipid profile in patients with type 2 diabetes mellitus at a tertiary care hospital: a retrospective study
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/4258af6838724b9dbcd7aabc1aba36d4
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Association between glycated hemoglobin (HbA1c) and the lipid profile in patients with type 2 diabetes mellitus at a tertiary care hospital: a retrospective study

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