In vivo base editing of post-mitotic sensory cells

Base editing allows the precise introduction of point mutations into cellular DNA without requiring double-stranded DNA breaks or homology-directed repair, which is inefficient in postmitotic cells. Here the authors demonstrate in vivo base editing of post-mitotic somatic cells in the postnatal mous...

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Autores principales:	Wei-Hsi Yeh, Hao Chiang, Holly A. Rees, Albert S. B. Edge, David R. Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/425b7eebb92745d5aeb9260de20796e0
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id	oai:doaj.org-article:425b7eebb92745d5aeb9260de20796e0
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spelling	oai:doaj.org-article:425b7eebb92745d5aeb9260de20796e02021-12-02T14:39:22ZIn vivo base editing of post-mitotic sensory cells10.1038/s41467-018-04580-32041-1723https://doaj.org/article/425b7eebb92745d5aeb9260de20796e02018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04580-3https://doaj.org/toc/2041-1723Base editing allows the precise introduction of point mutations into cellular DNA without requiring double-stranded DNA breaks or homology-directed repair, which is inefficient in postmitotic cells. Here the authors demonstrate in vivo base editing of post-mitotic somatic cells in the postnatal mouse inner ear with physiological outcomes.Wei-Hsi YehHao ChiangHolly A. ReesAlbert S. B. EdgeDavid R. LiuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wei-Hsi Yeh Hao Chiang Holly A. Rees Albert S. B. Edge David R. Liu In vivo base editing of post-mitotic sensory cells
description	Base editing allows the precise introduction of point mutations into cellular DNA without requiring double-stranded DNA breaks or homology-directed repair, which is inefficient in postmitotic cells. Here the authors demonstrate in vivo base editing of post-mitotic somatic cells in the postnatal mouse inner ear with physiological outcomes.
format	article
author	Wei-Hsi Yeh Hao Chiang Holly A. Rees Albert S. B. Edge David R. Liu
author_facet	Wei-Hsi Yeh Hao Chiang Holly A. Rees Albert S. B. Edge David R. Liu
author_sort	Wei-Hsi Yeh
title	In vivo base editing of post-mitotic sensory cells
title_short	In vivo base editing of post-mitotic sensory cells
title_full	In vivo base editing of post-mitotic sensory cells
title_fullStr	In vivo base editing of post-mitotic sensory cells
title_full_unstemmed	In vivo base editing of post-mitotic sensory cells
title_sort	in vivo base editing of post-mitotic sensory cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/425b7eebb92745d5aeb9260de20796e0
work_keys_str_mv	AT weihsiyeh invivobaseeditingofpostmitoticsensorycells AT haochiang invivobaseeditingofpostmitoticsensorycells AT hollyarees invivobaseeditingofpostmitoticsensorycells AT albertsbedge invivobaseeditingofpostmitoticsensorycells AT davidrliu invivobaseeditingofpostmitoticsensorycells
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In vivo base editing of post-mitotic sensory cells

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