Serum 25-hydroxyvitamin D predicts cognitive performance in adults

Hala Darwish,1 Pia Zeinoun,2 Husam Ghusn,3,4 Brigitte Khoury,2 Hani Tamim,5 Samia J Khoury6 1Hariri School of Nursing, Faculty of Medicine, American University of Beirut, Beirut, Lebanon; 2Psychiatry Department, Faculty of Medicine, American University of Beirut, Beirut, Lebanon; 3Internal Medicine...

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Autores principales:	Darwish H, Zeinoun P, Ghusn H, Khoury B, Tamim H, Khoury SJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/425cb76e05cb484885c1ca0b423b66a6
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spelling	oai:doaj.org-article:425cb76e05cb484885c1ca0b423b66a62021-12-02T01:38:03ZSerum 25-hydroxyvitamin D predicts cognitive performance in adults1178-2021https://doaj.org/article/425cb76e05cb484885c1ca0b423b66a62015-08-01T00:00:00Zhttp://www.dovepress.com/serum-25-hydroxyvitamin-d-predicts-cognitive-performance-in-adults-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Hala Darwish,1 Pia Zeinoun,2 Husam Ghusn,3,4 Brigitte Khoury,2 Hani Tamim,5 Samia J Khoury6 1Hariri School of Nursing, Faculty of Medicine, American University of Beirut, Beirut, Lebanon; 2Psychiatry Department, Faculty of Medicine, American University of Beirut, Beirut, Lebanon; 3Internal Medicine Department, Faculty of Medicine, American University of Beirut, Beirut, Lebanon; 4Geriatrics Department, Ain Wazein Hospital, El Chouf, Lebanon; 5Clinical Research Institute, Faculty of Medicine, American University of Beirut, Beirut, Lebanon; 6Neurology Department, Faculty of Medicine, American University of Beirut, Beirut, Lebanon Background: Vitamin D is an endogenous hormone known to regulate calcium levels in the body and plays a role in cognitive performance. Studies have shown an association between vitamin D deficiency and cognitive impairment in older adults. Lebanon has a high 25-hydroxyvitamin D (25(OH)D) deficiency prevalence across all age groups. Methods: In this cross-sectional study, we explored the cognitive performance and serum 25(OH)D levels using an electrochemoluminescent immunoassay in 254 older (>60 years) as well as younger (30–60 years) adults. Subjects’ characteristics, including age, years of education, wearing of veil, alcohol consumption, smoking, and physical exercise, were collected. Participants were screened for depression prior to cognitive screening using the Montreal Cognitive Assessment Arabic version. Visuospatial memory was tested using the Rey Complex Figure Test and Recognition Trial, and speed of processing was assessed using the Symbol Digit Modalities test. Results: Pearson’s correlation and stepwise linear regression analyses showed that a low vitamin D level was associated with greater risk of cognitive impairment in older as well as younger adults. Conclusion: These findings suggest that correction of vitamin D needs to be explored as an intervention to prevent cognitive impairment. Prospective longitudinal studies are needed to ascertain the effect of such interventions. Keywords: cognitive function, aging, neuro-psychological functionDarwish HZeinoun PGhusn HKhoury BTamim HKhoury SJDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 2217-2223 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Darwish H Zeinoun P Ghusn H Khoury B Tamim H Khoury SJ Serum 25-hydroxyvitamin D predicts cognitive performance in adults
description	Hala Darwish,1 Pia Zeinoun,2 Husam Ghusn,3,4 Brigitte Khoury,2 Hani Tamim,5 Samia J Khoury6 1Hariri School of Nursing, Faculty of Medicine, American University of Beirut, Beirut, Lebanon; 2Psychiatry Department, Faculty of Medicine, American University of Beirut, Beirut, Lebanon; 3Internal Medicine Department, Faculty of Medicine, American University of Beirut, Beirut, Lebanon; 4Geriatrics Department, Ain Wazein Hospital, El Chouf, Lebanon; 5Clinical Research Institute, Faculty of Medicine, American University of Beirut, Beirut, Lebanon; 6Neurology Department, Faculty of Medicine, American University of Beirut, Beirut, Lebanon Background: Vitamin D is an endogenous hormone known to regulate calcium levels in the body and plays a role in cognitive performance. Studies have shown an association between vitamin D deficiency and cognitive impairment in older adults. Lebanon has a high 25-hydroxyvitamin D (25(OH)D) deficiency prevalence across all age groups. Methods: In this cross-sectional study, we explored the cognitive performance and serum 25(OH)D levels using an electrochemoluminescent immunoassay in 254 older (>60 years) as well as younger (30–60 years) adults. Subjects’ characteristics, including age, years of education, wearing of veil, alcohol consumption, smoking, and physical exercise, were collected. Participants were screened for depression prior to cognitive screening using the Montreal Cognitive Assessment Arabic version. Visuospatial memory was tested using the Rey Complex Figure Test and Recognition Trial, and speed of processing was assessed using the Symbol Digit Modalities test. Results: Pearson’s correlation and stepwise linear regression analyses showed that a low vitamin D level was associated with greater risk of cognitive impairment in older as well as younger adults. Conclusion: These findings suggest that correction of vitamin D needs to be explored as an intervention to prevent cognitive impairment. Prospective longitudinal studies are needed to ascertain the effect of such interventions. Keywords: cognitive function, aging, neuro-psychological function
format	article
author	Darwish H Zeinoun P Ghusn H Khoury B Tamim H Khoury SJ
author_facet	Darwish H Zeinoun P Ghusn H Khoury B Tamim H Khoury SJ
author_sort	Darwish H
title	Serum 25-hydroxyvitamin D predicts cognitive performance in adults
title_short	Serum 25-hydroxyvitamin D predicts cognitive performance in adults
title_full	Serum 25-hydroxyvitamin D predicts cognitive performance in adults
title_fullStr	Serum 25-hydroxyvitamin D predicts cognitive performance in adults
title_full_unstemmed	Serum 25-hydroxyvitamin D predicts cognitive performance in adults
title_sort	serum 25-hydroxyvitamin d predicts cognitive performance in adults
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/425cb76e05cb484885c1ca0b423b66a6
work_keys_str_mv	AT darwishh serum25hydroxyvitamindpredictscognitiveperformanceinadults AT zeinounp serum25hydroxyvitamindpredictscognitiveperformanceinadults AT ghusnh serum25hydroxyvitamindpredictscognitiveperformanceinadults AT khouryb serum25hydroxyvitamindpredictscognitiveperformanceinadults AT tamimh serum25hydroxyvitamindpredictscognitiveperformanceinadults AT khourysj serum25hydroxyvitamindpredictscognitiveperformanceinadults
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Serum 25-hydroxyvitamin D predicts cognitive performance in adults

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