Effects of Chinese herbal formula Erxian decoction for treating osteoporosis: a systematic review

Jin-Yu Li,1,* Yu-Song Jia,1,* Li-Min Chai,1 Xiao-Hong Mu,1 Sheng Ma,1 Lin Xu,1 Xu Wei21Department of Orthopaedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2Department of Scientific Research, Wangjing Hospital, China Academy of Chine...

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Autores principales:	Li J, Jia Y, Chai L, Mu X, Ma S, Xu L, Wei X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Chinese herbal formula Erxian decoction osteoporosis systematic review meta-analysis Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/425ced9f7f8c4d1987c9d41f1eab06c7
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id	oai:doaj.org-article:425ced9f7f8c4d1987c9d41f1eab06c7
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spelling	oai:doaj.org-article:425ced9f7f8c4d1987c9d41f1eab06c72021-12-02T04:10:29ZEffects of Chinese herbal formula Erxian decoction for treating osteoporosis: a systematic review1178-1998https://doaj.org/article/425ced9f7f8c4d1987c9d41f1eab06c72017-01-01T00:00:00Zhttps://www.dovepress.com/effects-of-chinese-herbal-formula-erxian-decoction-for-treating-osteop-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Jin-Yu Li,1,* Yu-Song Jia,1,* Li-Min Chai,1 Xiao-Hong Mu,1 Sheng Ma,1 Lin Xu,1 Xu Wei21Department of Orthopaedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2Department of Scientific Research, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China *These authors contributed equally to this workPurpose: The aim is to systematically assess the effectiveness and safety of Chinese herbal formula Erxian decoction (EXD) for treating osteoporosis. Materials and methods: Six databases were searched from inception through September 17, 2016, without language restriction. All randomized controlled trials of EXD for osteoporosis were included. One or more outcome measures including fracture, change in bone mineral density (BMD), pain symptom improvement, bone biochemical markers, quality of life, adverse event or adverse drug reaction were evaluated. Study selection, data extraction, quality assessment, and data analyses were conducted according to Cochrane standards. Results: Eight trials including 644 patients investigated the effects of EXD in the treatment of osteoporosis. The methodological quality of the included trials was generally low. The meta-analysis from two trials showed favorable effects of EXD in improving BMD of lumbar spine (mean difference [MD]: 0.05 [0.03, 0.06]; I2=0%; P<0.00001) and BMD of femoral great trochanter (MD: 0.06 [0.02, 0.10]; I2=59%; P=0.005) compared with caltrate tablets. The other meta-analysis from two trials showed beneficial effects of EXD plus caltrate tablets and calcitriol in improving BMD of femoral neck (MD: 0.04 [0.00, 0.09]; I2=56%; P=0.04), the level of calcium (MD: 0.20 [0.15, 0.24]; I2=0%; P<0.00001), and phosphorus (MD: −0.28 [−0.39, −0.17]; I2=68%; P<0.00001) compared with caltrate tablets and calcitriol alone. The adverse drug reactions of EXD were mainly slight gastrointestinal symptoms.Conclusion: The study provides suggestive evidence of the superiority of EXD monotherapy or combination therapy over basic supplements for treating osteoporosis. However, the evidence remains weak. More rigorously designed and measured, randomized double-blind, placebo-controlled trials with larger sample size are needed to verify the current conclusions.Keywords: Chinese herbal formula, Erxian decoction, osteoporosis, systematic review, meta-analysisLi JJia YChai LMu XMa SXu LWei XDove Medical PressarticleChinese herbal formulaErxian decoctionosteoporosissystematic reviewmeta-analysisGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 12, Pp 45-53 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chinese herbal formula Erxian decoction osteoporosis systematic review meta-analysis Geriatrics RC952-954.6
spellingShingle	Chinese herbal formula Erxian decoction osteoporosis systematic review meta-analysis Geriatrics RC952-954.6 Li J Jia Y Chai L Mu X Ma S Xu L Wei X Effects of Chinese herbal formula Erxian decoction for treating osteoporosis: a systematic review
description	Jin-Yu Li,1,* Yu-Song Jia,1,* Li-Min Chai,1 Xiao-Hong Mu,1 Sheng Ma,1 Lin Xu,1 Xu Wei21Department of Orthopaedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2Department of Scientific Research, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China *These authors contributed equally to this workPurpose: The aim is to systematically assess the effectiveness and safety of Chinese herbal formula Erxian decoction (EXD) for treating osteoporosis. Materials and methods: Six databases were searched from inception through September 17, 2016, without language restriction. All randomized controlled trials of EXD for osteoporosis were included. One or more outcome measures including fracture, change in bone mineral density (BMD), pain symptom improvement, bone biochemical markers, quality of life, adverse event or adverse drug reaction were evaluated. Study selection, data extraction, quality assessment, and data analyses were conducted according to Cochrane standards. Results: Eight trials including 644 patients investigated the effects of EXD in the treatment of osteoporosis. The methodological quality of the included trials was generally low. The meta-analysis from two trials showed favorable effects of EXD in improving BMD of lumbar spine (mean difference [MD]: 0.05 [0.03, 0.06]; I2=0%; P<0.00001) and BMD of femoral great trochanter (MD: 0.06 [0.02, 0.10]; I2=59%; P=0.005) compared with caltrate tablets. The other meta-analysis from two trials showed beneficial effects of EXD plus caltrate tablets and calcitriol in improving BMD of femoral neck (MD: 0.04 [0.00, 0.09]; I2=56%; P=0.04), the level of calcium (MD: 0.20 [0.15, 0.24]; I2=0%; P<0.00001), and phosphorus (MD: −0.28 [−0.39, −0.17]; I2=68%; P<0.00001) compared with caltrate tablets and calcitriol alone. The adverse drug reactions of EXD were mainly slight gastrointestinal symptoms.Conclusion: The study provides suggestive evidence of the superiority of EXD monotherapy or combination therapy over basic supplements for treating osteoporosis. However, the evidence remains weak. More rigorously designed and measured, randomized double-blind, placebo-controlled trials with larger sample size are needed to verify the current conclusions.Keywords: Chinese herbal formula, Erxian decoction, osteoporosis, systematic review, meta-analysis
format	article
author	Li J Jia Y Chai L Mu X Ma S Xu L Wei X
author_facet	Li J Jia Y Chai L Mu X Ma S Xu L Wei X
author_sort	Li J
title	Effects of Chinese herbal formula Erxian decoction for treating osteoporosis: a systematic review
title_short	Effects of Chinese herbal formula Erxian decoction for treating osteoporosis: a systematic review
title_full	Effects of Chinese herbal formula Erxian decoction for treating osteoporosis: a systematic review
title_fullStr	Effects of Chinese herbal formula Erxian decoction for treating osteoporosis: a systematic review
title_full_unstemmed	Effects of Chinese herbal formula Erxian decoction for treating osteoporosis: a systematic review
title_sort	effects of chinese herbal formula erxian decoction for treating osteoporosis: a systematic review
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/425ced9f7f8c4d1987c9d41f1eab06c7
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_version_	1718401363783712768

Effects of Chinese herbal formula Erxian decoction for treating osteoporosis: a systematic review

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