Contribution of Different Phenotypes of Obesity to Metabolic Abnormalities from a Cross-Sectional Study in the Northwest China

Xixuan Lu,1,* Qiang Wang,2,* Haiyan Liang,1 Li Xu,3 Liping Sha,1 Yuemei Wu,1 Liting Ma,1 Ping Yang,1 Hong Lei1 1Department of Endocrinology, Cardiovascular and Cerebrovascular Disease Hospital, Ningxia Medical University General Hospital, Yinchuan, Ningxia, People’s Republic of China...

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Autores principales: Lu X, Wang Q, Liang H, Xu L, Sha L, Wu Y, Ma L, Yang P, Lei H
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Publicado: Dove Medical Press 2021
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spelling oai:doaj.org-article:425ddd8823de45a9b0b04cc83be67d982021-12-02T18:34:25ZContribution of Different Phenotypes of Obesity to Metabolic Abnormalities from a Cross-Sectional Study in the Northwest China1178-7007https://doaj.org/article/425ddd8823de45a9b0b04cc83be67d982021-07-01T00:00:00Zhttps://www.dovepress.com/contribution-of-different-phenotypes-of-obesity-to-metabolic-abnormali-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Xixuan Lu,1,* Qiang Wang,2,* Haiyan Liang,1 Li Xu,3 Liping Sha,1 Yuemei Wu,1 Liting Ma,1 Ping Yang,1 Hong Lei1 1Department of Endocrinology, Cardiovascular and Cerebrovascular Disease Hospital, Ningxia Medical University General Hospital, Yinchuan, Ningxia, People’s Republic of China; 2Department of Medical Office, People’s Hospital of Ningxia Hui Autonomous Region, Yinchuan, Ningxia, People’s Republic of China; 3Department of Radiology, People’s Liberation Army’s Joint Service for the 942nd Hospital, Yinchuan, Ningxia, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xixuan LuDepartment of Endocrinology, Cardiovascular and Cerebrovascular Disease Hospital, Ningxia Medical University General Hospital, No. 804, Shengli South Street, Xingqing District, Yinchuan, 750004, Ningxia, People’s Republic of ChinaTel +860951-6746645Email xixuan86@163.comBackground: This study has been conducted to explore the correlation between phenotypes of obesity and metabolic comorbidities.Methods: This cross-sectional study recruited 14,724 adults aged ≥ 18 years with a randomized stratified sampling strategy. Obesity was classified into four types according to body mass index (BMI) and waist-to-height ratio (WHtR): normal weight with central obesity (NWCO) and without (NW) CO, and obese or overweight with (OBCO) and without (OB) central obesity. Uric acid (UA), fasting blood glucose (FBG), and lipid profile were measured.Results: The prevalence of hyperuricemia in the 4 groups (NW, NWCO, OB and OBCO) was 3.7%, 5.6%, 8.7% and 12.4%, whilst the prevalence of hypertriglyceridemia was 13.4%, 27.4%, 30.3% and 43.7%, separately. The prevalence of hypo-high-density lipoprotein cholesterolemia (hypo-HDL emia) was 20.1%, 21.4%, 30.8% and 27.9%, while the prevalence of hyper-low-density lipoprotein cholesterolemia (hyper-LDL emia) was 9.8%, 24.4%, 12.3% and 27.9%. The prevalence of hypercholesterolemia was 11.2%, 23.5%, 14.7%, 28.5% and the prevalence of hyperglycemia was 9.7%, 22.6%, 18.5%, and 27.0%, respectively. The prevalence of hypertension was 6.9%, 13.1%, 14.7%, and 20.6%. For various metabolic abnormalities, OBCO have the highest risks compared with NW (hyperuricemia: adjusted OR (aOR)= 2.60; hypertriglyceridemia: aOR= 3.19; hypercholesterolemia: aOR= 1.48; hyper LDLemia: aOR= 2.21; hypo HDLemia: aOR= 1.42; hyperglycemia: aOR= 1.95; hypertension: aOR= 2.16). The risk of hyper LDLemia, hypercholesterolemia and hyperglycemia in the NWCO group was higher than that in the OB group (hyperLDLemia: aOR: 1.69 vs 0.97; hypercholesterolemia: aOR: 1.27 vs 1.24; hyperglycemia: aOR: 1.62 vs 1.28).Conclusion: Different phenotypes of obesity are significantly associated with metabolic abnormalities. NWCO is more closely associated with hypercholesterolemia, hyperglycemia and hyper LDLemia. General obesity and central obesity have a synergistic effect on the diseases.Keywords: obesity, central obesity, metabolic abnormalities, BMI, WHtRLu XWang QLiang HXu LSha LWu YMa LYang PLei HDove Medical Pressarticleobesitycentral obesitymetabolic abnormalitiesbmiwhtrSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 3111-3121 (2021)
institution DOAJ
collection DOAJ
language EN
topic obesity
central obesity
metabolic abnormalities
bmi
whtr
Specialties of internal medicine
RC581-951
spellingShingle obesity
central obesity
metabolic abnormalities
bmi
whtr
Specialties of internal medicine
RC581-951
Lu X
Wang Q
Liang H
Xu L
Sha L
Wu Y
Ma L
Yang P
Lei H
Contribution of Different Phenotypes of Obesity to Metabolic Abnormalities from a Cross-Sectional Study in the Northwest China
description Xixuan Lu,1,* Qiang Wang,2,* Haiyan Liang,1 Li Xu,3 Liping Sha,1 Yuemei Wu,1 Liting Ma,1 Ping Yang,1 Hong Lei1 1Department of Endocrinology, Cardiovascular and Cerebrovascular Disease Hospital, Ningxia Medical University General Hospital, Yinchuan, Ningxia, People’s Republic of China; 2Department of Medical Office, People’s Hospital of Ningxia Hui Autonomous Region, Yinchuan, Ningxia, People’s Republic of China; 3Department of Radiology, People’s Liberation Army’s Joint Service for the 942nd Hospital, Yinchuan, Ningxia, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xixuan LuDepartment of Endocrinology, Cardiovascular and Cerebrovascular Disease Hospital, Ningxia Medical University General Hospital, No. 804, Shengli South Street, Xingqing District, Yinchuan, 750004, Ningxia, People’s Republic of ChinaTel +860951-6746645Email xixuan86@163.comBackground: This study has been conducted to explore the correlation between phenotypes of obesity and metabolic comorbidities.Methods: This cross-sectional study recruited 14,724 adults aged ≥ 18 years with a randomized stratified sampling strategy. Obesity was classified into four types according to body mass index (BMI) and waist-to-height ratio (WHtR): normal weight with central obesity (NWCO) and without (NW) CO, and obese or overweight with (OBCO) and without (OB) central obesity. Uric acid (UA), fasting blood glucose (FBG), and lipid profile were measured.Results: The prevalence of hyperuricemia in the 4 groups (NW, NWCO, OB and OBCO) was 3.7%, 5.6%, 8.7% and 12.4%, whilst the prevalence of hypertriglyceridemia was 13.4%, 27.4%, 30.3% and 43.7%, separately. The prevalence of hypo-high-density lipoprotein cholesterolemia (hypo-HDL emia) was 20.1%, 21.4%, 30.8% and 27.9%, while the prevalence of hyper-low-density lipoprotein cholesterolemia (hyper-LDL emia) was 9.8%, 24.4%, 12.3% and 27.9%. The prevalence of hypercholesterolemia was 11.2%, 23.5%, 14.7%, 28.5% and the prevalence of hyperglycemia was 9.7%, 22.6%, 18.5%, and 27.0%, respectively. The prevalence of hypertension was 6.9%, 13.1%, 14.7%, and 20.6%. For various metabolic abnormalities, OBCO have the highest risks compared with NW (hyperuricemia: adjusted OR (aOR)= 2.60; hypertriglyceridemia: aOR= 3.19; hypercholesterolemia: aOR= 1.48; hyper LDLemia: aOR= 2.21; hypo HDLemia: aOR= 1.42; hyperglycemia: aOR= 1.95; hypertension: aOR= 2.16). The risk of hyper LDLemia, hypercholesterolemia and hyperglycemia in the NWCO group was higher than that in the OB group (hyperLDLemia: aOR: 1.69 vs 0.97; hypercholesterolemia: aOR: 1.27 vs 1.24; hyperglycemia: aOR: 1.62 vs 1.28).Conclusion: Different phenotypes of obesity are significantly associated with metabolic abnormalities. NWCO is more closely associated with hypercholesterolemia, hyperglycemia and hyper LDLemia. General obesity and central obesity have a synergistic effect on the diseases.Keywords: obesity, central obesity, metabolic abnormalities, BMI, WHtR
format article
author Lu X
Wang Q
Liang H
Xu L
Sha L
Wu Y
Ma L
Yang P
Lei H
author_facet Lu X
Wang Q
Liang H
Xu L
Sha L
Wu Y
Ma L
Yang P
Lei H
author_sort Lu X
title Contribution of Different Phenotypes of Obesity to Metabolic Abnormalities from a Cross-Sectional Study in the Northwest China
title_short Contribution of Different Phenotypes of Obesity to Metabolic Abnormalities from a Cross-Sectional Study in the Northwest China
title_full Contribution of Different Phenotypes of Obesity to Metabolic Abnormalities from a Cross-Sectional Study in the Northwest China
title_fullStr Contribution of Different Phenotypes of Obesity to Metabolic Abnormalities from a Cross-Sectional Study in the Northwest China
title_full_unstemmed Contribution of Different Phenotypes of Obesity to Metabolic Abnormalities from a Cross-Sectional Study in the Northwest China
title_sort contribution of different phenotypes of obesity to metabolic abnormalities from a cross-sectional study in the northwest china
publisher Dove Medical Press
publishDate 2021
url https://doaj.org/article/425ddd8823de45a9b0b04cc83be67d98
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