THE CHANGES IN SEMEN LYMPHOCYTE SUBPOPULATION’S RATIO IN MEN INFERTILITY

Abstract. The aim of present study was to investigate the ratios of semen lymphocyte subpopulations in males with infertility. Twenty-six men (20 to 45 years old) suffering from different genital diseases (chronic prostatitis, idiopathic varicocoele, testicular atrophy) were enrolled into the study....

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Autores principales:	A. V. Semenov, N. Yu. Sotnikova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	lymphocytes activation lymphocytes apoptosis males with infertility semen flow cytometry Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/4260da167779447cbf6cd59ebe433d4e
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spelling	oai:doaj.org-article:4260da167779447cbf6cd59ebe433d4e2021-11-18T08:03:38ZTHE CHANGES IN SEMEN LYMPHOCYTE SUBPOPULATION’S RATIO IN MEN INFERTILITY1563-06252313-741X10.15789/1563-0625-2007-1-91-96https://doaj.org/article/4260da167779447cbf6cd59ebe433d4e2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/145https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The aim of present study was to investigate the ratios of semen lymphocyte subpopulations in males with infertility. Twenty-six men (20 to 45 years old) suffering from different genital diseases (chronic prostatitis, idiopathic varicocoele, testicular atrophy) were enrolled into the study. Six healthy age-matched normozoospermic male volunteers with normal fertility comprised a control group. Lymphocyte phenotyping was performed by flow cytometric technique. The patients with pathospermia showed increased numbers of CD25+ lymphocytes (p < 0.05), and unchanged levels of CD95+ cells, thus leading to increased CD25+/CD95+ ratio. In the patients with normozoospermia, the value of this index was 0.94±0.18. Increase of this parameter to > 1.2, as well as its reduction to < 0.7 was associated with sterility. We suggest that suppressed apoptosis of activated lymphocytes in semen may be potentially dangerous to spermatogenesis, since both immune response and associated inflammatory reactions can cause nonspecific lesions of surrounding tissues, and induction of pathospermia.A. V. SemenovN. Yu. SotnikovaSPb RAACIarticlelymphocytes activationlymphocytes apoptosismales with infertilitysemenflow cytometryImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 9, Iss 1, Pp 91-96 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	lymphocytes activation lymphocytes apoptosis males with infertility semen flow cytometry Immunologic diseases. Allergy RC581-607
spellingShingle	lymphocytes activation lymphocytes apoptosis males with infertility semen flow cytometry Immunologic diseases. Allergy RC581-607 A. V. Semenov N. Yu. Sotnikova THE CHANGES IN SEMEN LYMPHOCYTE SUBPOPULATION’S RATIO IN MEN INFERTILITY
description	Abstract. The aim of present study was to investigate the ratios of semen lymphocyte subpopulations in males with infertility. Twenty-six men (20 to 45 years old) suffering from different genital diseases (chronic prostatitis, idiopathic varicocoele, testicular atrophy) were enrolled into the study. Six healthy age-matched normozoospermic male volunteers with normal fertility comprised a control group. Lymphocyte phenotyping was performed by flow cytometric technique. The patients with pathospermia showed increased numbers of CD25+ lymphocytes (p < 0.05), and unchanged levels of CD95+ cells, thus leading to increased CD25+/CD95+ ratio. In the patients with normozoospermia, the value of this index was 0.94±0.18. Increase of this parameter to > 1.2, as well as its reduction to < 0.7 was associated with sterility. We suggest that suppressed apoptosis of activated lymphocytes in semen may be potentially dangerous to spermatogenesis, since both immune response and associated inflammatory reactions can cause nonspecific lesions of surrounding tissues, and induction of pathospermia.
format	article
author	A. V. Semenov N. Yu. Sotnikova
author_facet	A. V. Semenov N. Yu. Sotnikova
author_sort	A. V. Semenov
title	THE CHANGES IN SEMEN LYMPHOCYTE SUBPOPULATION’S RATIO IN MEN INFERTILITY
title_short	THE CHANGES IN SEMEN LYMPHOCYTE SUBPOPULATION’S RATIO IN MEN INFERTILITY
title_full	THE CHANGES IN SEMEN LYMPHOCYTE SUBPOPULATION’S RATIO IN MEN INFERTILITY
title_fullStr	THE CHANGES IN SEMEN LYMPHOCYTE SUBPOPULATION’S RATIO IN MEN INFERTILITY
title_full_unstemmed	THE CHANGES IN SEMEN LYMPHOCYTE SUBPOPULATION’S RATIO IN MEN INFERTILITY
title_sort	changes in semen lymphocyte subpopulation’s ratio in men infertility
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/4260da167779447cbf6cd59ebe433d4e
work_keys_str_mv	AT avsemenov thechangesinsemenlymphocytesubpopulationsratioinmeninfertility AT nyusotnikova thechangesinsemenlymphocytesubpopulationsratioinmeninfertility AT avsemenov changesinsemenlymphocytesubpopulationsratioinmeninfertility AT nyusotnikova changesinsemenlymphocytesubpopulationsratioinmeninfertility
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THE CHANGES IN SEMEN LYMPHOCYTE SUBPOPULATION’S RATIO IN MEN INFERTILITY

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