The anti-diabetic drug metformin reduces BACE1 protein level by interfering with the MID1 complex.

The anti-diabetic drug metformin reduces BACE1 protein level by interfering with the MID1 complex.

Alzheimer's disease (AD), the most common form of dementia in the elderly, is characterized by two neuropathological hallmarks: senile plaques, which are composed of Aβ peptides, and neurofibrillary tangles, which are composed of hyperphosphorylated TAU protein. Diabetic patients with dysregula...

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Autores principales: Moritz M Hettich, Frank Matthes, Devon P Ryan, Nadine Griesche, Susanne Schröder, Stephanie Dorn, Sybille Krauβ, Dan Ehninger
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
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Science
Q
Acceso en línea:https://doaj.org/article/42649d0e94c24c4ca876da763496d3f4
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