Carotid intima-media thickness and plaque occurrence in predicting stable angiographic coronary artery disease

Chao-Chien Chang,1,2 Mei-Ling Chang,2 Chi-Hung Huang,2 Po-Ching Chou,2 Eng-Thiam Ong,2 Chih-Hui Chin2 1Department of Pharmacology, School of Medicine, Taipei Medical University, 2Division of Cardiology, Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan Background: Carotid int...

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Autores principales:	Chang CC, Chang ML, Huang CH, Chou PC, Ong ET, Chin CH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	carotid plaque intima-media thickness coronary artery disease ultrasonography Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/426abd6d92a7496099624c592e16e9a3
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spelling	oai:doaj.org-article:426abd6d92a7496099624c592e16e9a32021-12-02T03:01:11ZCarotid intima-media thickness and plaque occurrence in predicting stable angiographic coronary artery disease1178-1998https://doaj.org/article/426abd6d92a7496099624c592e16e9a32013-09-01T00:00:00Zhttps://www.dovepress.com/carotid-intima-media-thickness-and-plaque-occurrence-in-predicting-sta-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Chao-Chien Chang,1,2 Mei-Ling Chang,2 Chi-Hung Huang,2 Po-Ching Chou,2 Eng-Thiam Ong,2 Chih-Hui Chin2 1Department of Pharmacology, School of Medicine, Taipei Medical University, 2Division of Cardiology, Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan Background: Carotid intima-media thickness (CIMT) and plaque formation have been used as surrogate end-points for evaluating the regression and/or progression of atherosclerotic cardiovascular disease, but their predictive value for stable coronary artery disease (CAD) is inconclusive. Methods: Carotid ultrasonography was performed in patients who underwent noninvasive multislice computed tomography (MSCT) angiography for CAD suspected, due to chest pain. CIMT and plaque formation on the left and right common carotid arteries (CCAs), carotid bulb (CB), and proximal internal carotid arteries (ICAs) were evaluated, and the relationship between angiographic CAD, CIMT, and plaque formation was determined. Results: 120 patients (95 male; 25 female), with a mean age ± standard deviation of 61 ± 11 years (range: 35–89 years) were recruited. Because age had a significant impact on CAD (r = 0.191; P = 0.036), CCA plaques (r = 0.368; P = 0.001), ICA plaques (r = 0.334; P = 0.004), and mean CIMT (r = 0.436; P = 0.001), patients were divided into two groups aged <60 years and ≥60 years. In the <60 years group, CIMT-CB was significantly higher in patients with CAD (P = 0.041), while in the ≥60 years group, mean CIMT, CIMT-CCA, and CIMT-CB were significantly higher in patients with CAD (P < 0.05, for each). In both groups, the occurrence of carotid plaques was significantly higher in patients with CAD than in those without CAD (P < 0.007, for each). After controlling for other risk factors, carotid plaques were an independent predictor of CAD in both groups (P < 0.05, for each), while CIMT-CB could independently predict CAD only in patients ≥60 years old (P = 0.031). Conclusion: Our findings suggest that carotid plaques are a strong predictor of stable CAD. However, CIMT-CB could predict stable CAD only in patients over 60 years of age. Keywords: carotid plaque, intima-media thickness, coronary artery disease, ultrasonographyChang CCChang MLHuang CHChou PCOng ETChin CHDove Medical Pressarticlecarotid plaqueintima-media thicknesscoronary artery diseaseultrasonographyGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 8, Pp 1283-1288 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	carotid plaque intima-media thickness coronary artery disease ultrasonography Geriatrics RC952-954.6
spellingShingle	carotid plaque intima-media thickness coronary artery disease ultrasonography Geriatrics RC952-954.6 Chang CC Chang ML Huang CH Chou PC Ong ET Chin CH Carotid intima-media thickness and plaque occurrence in predicting stable angiographic coronary artery disease
description	Chao-Chien Chang,1,2 Mei-Ling Chang,2 Chi-Hung Huang,2 Po-Ching Chou,2 Eng-Thiam Ong,2 Chih-Hui Chin2 1Department of Pharmacology, School of Medicine, Taipei Medical University, 2Division of Cardiology, Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan Background: Carotid intima-media thickness (CIMT) and plaque formation have been used as surrogate end-points for evaluating the regression and/or progression of atherosclerotic cardiovascular disease, but their predictive value for stable coronary artery disease (CAD) is inconclusive. Methods: Carotid ultrasonography was performed in patients who underwent noninvasive multislice computed tomography (MSCT) angiography for CAD suspected, due to chest pain. CIMT and plaque formation on the left and right common carotid arteries (CCAs), carotid bulb (CB), and proximal internal carotid arteries (ICAs) were evaluated, and the relationship between angiographic CAD, CIMT, and plaque formation was determined. Results: 120 patients (95 male; 25 female), with a mean age ± standard deviation of 61 ± 11 years (range: 35–89 years) were recruited. Because age had a significant impact on CAD (r = 0.191; P = 0.036), CCA plaques (r = 0.368; P = 0.001), ICA plaques (r = 0.334; P = 0.004), and mean CIMT (r = 0.436; P = 0.001), patients were divided into two groups aged <60 years and ≥60 years. In the <60 years group, CIMT-CB was significantly higher in patients with CAD (P = 0.041), while in the ≥60 years group, mean CIMT, CIMT-CCA, and CIMT-CB were significantly higher in patients with CAD (P < 0.05, for each). In both groups, the occurrence of carotid plaques was significantly higher in patients with CAD than in those without CAD (P < 0.007, for each). After controlling for other risk factors, carotid plaques were an independent predictor of CAD in both groups (P < 0.05, for each), while CIMT-CB could independently predict CAD only in patients ≥60 years old (P = 0.031). Conclusion: Our findings suggest that carotid plaques are a strong predictor of stable CAD. However, CIMT-CB could predict stable CAD only in patients over 60 years of age. Keywords: carotid plaque, intima-media thickness, coronary artery disease, ultrasonography
format	article
author	Chang CC Chang ML Huang CH Chou PC Ong ET Chin CH
author_facet	Chang CC Chang ML Huang CH Chou PC Ong ET Chin CH
author_sort	Chang CC
title	Carotid intima-media thickness and plaque occurrence in predicting stable angiographic coronary artery disease
title_short	Carotid intima-media thickness and plaque occurrence in predicting stable angiographic coronary artery disease
title_full	Carotid intima-media thickness and plaque occurrence in predicting stable angiographic coronary artery disease
title_fullStr	Carotid intima-media thickness and plaque occurrence in predicting stable angiographic coronary artery disease
title_full_unstemmed	Carotid intima-media thickness and plaque occurrence in predicting stable angiographic coronary artery disease
title_sort	carotid intima-media thickness and plaque occurrence in predicting stable angiographic coronary artery disease
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/426abd6d92a7496099624c592e16e9a3
work_keys_str_mv	AT changcc carotidintimamediathicknessandplaqueoccurrenceinpredictingstableangiographiccoronaryarterydisease AT changml carotidintimamediathicknessandplaqueoccurrenceinpredictingstableangiographiccoronaryarterydisease AT huangch carotidintimamediathicknessandplaqueoccurrenceinpredictingstableangiographiccoronaryarterydisease AT choupc carotidintimamediathicknessandplaqueoccurrenceinpredictingstableangiographiccoronaryarterydisease AT onget carotidintimamediathicknessandplaqueoccurrenceinpredictingstableangiographiccoronaryarterydisease AT chinch carotidintimamediathicknessandplaqueoccurrenceinpredictingstableangiographiccoronaryarterydisease
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Carotid intima-media thickness and plaque occurrence in predicting stable angiographic coronary artery disease

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