Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph

Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph

The HLA-A*68:01 allele has been associated with severe influenza disease during the 2009 influenza pandemic. Here, the authors analyze influenza nucleoprotein specific HLA-A*68:01-restricted CD8+ T cells from human donors and show immunodominance of these cells in approximately 35% of HLA-A*68:01-ex...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: C. E. van de Sandt, E. B. Clemens, E. J. Grant, L. C. Rowntree, S. Sant, H. Halim, J. Crowe, A. C. Cheng, T. C. Kotsimbos, M. Richards, A. Miller, S. Y. C. Tong, J. Rossjohn, T. H. O. Nguyen, S. Gras, W. Chen, K. Kedzierska
Format: article
Langue:EN
Publié: Nature Portfolio 2019
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/426b139667f44683bec66afdc2b05f65
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
id oai:doaj.org-article:426b139667f44683bec66afdc2b05f65
record_format dspace
spelling oai:doaj.org-article:426b139667f44683bec66afdc2b05f652021-12-02T16:51:01ZChallenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph10.1038/s41467-019-13346-42041-1723https://doaj.org/article/426b139667f44683bec66afdc2b05f652019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13346-4https://doaj.org/toc/2041-1723The HLA-A*68:01 allele has been associated with severe influenza disease during the 2009 influenza pandemic. Here, the authors analyze influenza nucleoprotein specific HLA-A*68:01-restricted CD8+ T cells from human donors and show immunodominance of these cells in approximately 35% of HLA-A*68:01-expressing donors.C. E. van de SandtE. B. ClemensE. J. GrantL. C. RowntreeS. SantH. HalimJ. CroweA. C. ChengT. C. KotsimbosM. RichardsA. MillerS. Y. C. TongJ. RossjohnT. H. O. NguyenS. GrasW. ChenK. KedzierskaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
C. E. van de Sandt
E. B. Clemens
E. J. Grant
L. C. Rowntree
S. Sant
H. Halim
J. Crowe
A. C. Cheng
T. C. Kotsimbos
M. Richards
A. Miller
S. Y. C. Tong
J. Rossjohn
T. H. O. Nguyen
S. Gras
W. Chen
K. Kedzierska
Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph
description The HLA-A*68:01 allele has been associated with severe influenza disease during the 2009 influenza pandemic. Here, the authors analyze influenza nucleoprotein specific HLA-A*68:01-restricted CD8+ T cells from human donors and show immunodominance of these cells in approximately 35% of HLA-A*68:01-expressing donors.
format article
author C. E. van de Sandt
E. B. Clemens
E. J. Grant
L. C. Rowntree
S. Sant
H. Halim
J. Crowe
A. C. Cheng
T. C. Kotsimbos
M. Richards
A. Miller
S. Y. C. Tong
J. Rossjohn
T. H. O. Nguyen
S. Gras
W. Chen
K. Kedzierska
author_facet C. E. van de Sandt
E. B. Clemens
E. J. Grant
L. C. Rowntree
S. Sant
H. Halim
J. Crowe
A. C. Cheng
T. C. Kotsimbos
M. Richards
A. Miller
S. Y. C. Tong
J. Rossjohn
T. H. O. Nguyen
S. Gras
W. Chen
K. Kedzierska
author_sort C. E. van de Sandt
title Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph
title_short Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph
title_full Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph
title_fullStr Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph
title_full_unstemmed Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph
title_sort challenging immunodominance of influenza-specific cd8+ t cell responses restricted by the risk-associated hla-a*68:01 allomorph
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/426b139667f44683bec66afdc2b05f65
work_keys_str_mv AT cevandesandt challengingimmunodominanceofinfluenzaspecificcd8tcellresponsesrestrictedbytheriskassociatedhlaa6801allomorph
AT ebclemens challengingimmunodominanceofinfluenzaspecificcd8tcellresponsesrestrictedbytheriskassociatedhlaa6801allomorph
AT ejgrant challengingimmunodominanceofinfluenzaspecificcd8tcellresponsesrestrictedbytheriskassociatedhlaa6801allomorph
AT lcrowntree challengingimmunodominanceofinfluenzaspecificcd8tcellresponsesrestrictedbytheriskassociatedhlaa6801allomorph
AT ssant challengingimmunodominanceofinfluenzaspecificcd8tcellresponsesrestrictedbytheriskassociatedhlaa6801allomorph
AT hhalim challengingimmunodominanceofinfluenzaspecificcd8tcellresponsesrestrictedbytheriskassociatedhlaa6801allomorph
AT jcrowe challengingimmunodominanceofinfluenzaspecificcd8tcellresponsesrestrictedbytheriskassociatedhlaa6801allomorph
AT accheng challengingimmunodominanceofinfluenzaspecificcd8tcellresponsesrestrictedbytheriskassociatedhlaa6801allomorph
AT tckotsimbos challengingimmunodominanceofinfluenzaspecificcd8tcellresponsesrestrictedbytheriskassociatedhlaa6801allomorph
AT mrichards challengingimmunodominanceofinfluenzaspecificcd8tcellresponsesrestrictedbytheriskassociatedhlaa6801allomorph
AT amiller challengingimmunodominanceofinfluenzaspecificcd8tcellresponsesrestrictedbytheriskassociatedhlaa6801allomorph
AT syctong challengingimmunodominanceofinfluenzaspecificcd8tcellresponsesrestrictedbytheriskassociatedhlaa6801allomorph
AT jrossjohn challengingimmunodominanceofinfluenzaspecificcd8tcellresponsesrestrictedbytheriskassociatedhlaa6801allomorph
AT thonguyen challengingimmunodominanceofinfluenzaspecificcd8tcellresponsesrestrictedbytheriskassociatedhlaa6801allomorph
AT sgras challengingimmunodominanceofinfluenzaspecificcd8tcellresponsesrestrictedbytheriskassociatedhlaa6801allomorph
AT wchen challengingimmunodominanceofinfluenzaspecificcd8tcellresponsesrestrictedbytheriskassociatedhlaa6801allomorph
AT kkedzierska challengingimmunodominanceofinfluenzaspecificcd8tcellresponsesrestrictedbytheriskassociatedhlaa6801allomorph
_version_ 1718382972768354304

Documents similaires