Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph

Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph

The HLA-A*68:01 allele has been associated with severe influenza disease during the 2009 influenza pandemic. Here, the authors analyze influenza nucleoprotein specific HLA-A*68:01-restricted CD8+ T cells from human donors and show immunodominance of these cells in approximately 35% of HLA-A*68:01-ex...

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Autores principales: C. E. van de Sandt, E. B. Clemens, E. J. Grant, L. C. Rowntree, S. Sant, H. Halim, J. Crowe, A. C. Cheng, T. C. Kotsimbos, M. Richards, A. Miller, S. Y. C. Tong, J. Rossjohn, T. H. O. Nguyen, S. Gras, W. Chen, K. Kedzierska
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Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/426b139667f44683bec66afdc2b05f65
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spelling oai:doaj.org-article:426b139667f44683bec66afdc2b05f652021-12-02T16:51:01ZChallenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph10.1038/s41467-019-13346-42041-1723https://doaj.org/article/426b139667f44683bec66afdc2b05f652019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13346-4https://doaj.org/toc/2041-1723The HLA-A*68:01 allele has been associated with severe influenza disease during the 2009 influenza pandemic. Here, the authors analyze influenza nucleoprotein specific HLA-A*68:01-restricted CD8+ T cells from human donors and show immunodominance of these cells in approximately 35% of HLA-A*68:01-expressing donors.C. E. van de SandtE. B. ClemensE. J. GrantL. C. RowntreeS. SantH. HalimJ. CroweA. C. ChengT. C. KotsimbosM. RichardsA. MillerS. Y. C. TongJ. RossjohnT. H. O. NguyenS. GrasW. ChenK. KedzierskaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
C. E. van de Sandt
E. B. Clemens
E. J. Grant
L. C. Rowntree
S. Sant
H. Halim
J. Crowe
A. C. Cheng
T. C. Kotsimbos
M. Richards
A. Miller
S. Y. C. Tong
J. Rossjohn
T. H. O. Nguyen
S. Gras
W. Chen
K. Kedzierska
Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph
description The HLA-A*68:01 allele has been associated with severe influenza disease during the 2009 influenza pandemic. Here, the authors analyze influenza nucleoprotein specific HLA-A*68:01-restricted CD8+ T cells from human donors and show immunodominance of these cells in approximately 35% of HLA-A*68:01-expressing donors.
format article
author C. E. van de Sandt
E. B. Clemens
E. J. Grant
L. C. Rowntree
S. Sant
H. Halim
J. Crowe
A. C. Cheng
T. C. Kotsimbos
M. Richards
A. Miller
S. Y. C. Tong
J. Rossjohn
T. H. O. Nguyen
S. Gras
W. Chen
K. Kedzierska
author_facet C. E. van de Sandt
E. B. Clemens
E. J. Grant
L. C. Rowntree
S. Sant
H. Halim
J. Crowe
A. C. Cheng
T. C. Kotsimbos
M. Richards
A. Miller
S. Y. C. Tong
J. Rossjohn
T. H. O. Nguyen
S. Gras
W. Chen
K. Kedzierska
author_sort C. E. van de Sandt
title Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph
title_short Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph
title_full Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph
title_fullStr Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph
title_full_unstemmed Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph
title_sort challenging immunodominance of influenza-specific cd8+ t cell responses restricted by the risk-associated hla-a*68:01 allomorph
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/426b139667f44683bec66afdc2b05f65
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