Nanoparticles And Human Saliva: A Step Towards Drug Delivery Systems For Dental And Craniofacial Biomaterials

Rafal Pokrowiecki,1–3 Jacek Wojnarowicz,4 Tomasz Zareba,2 Iwona Koltsov,4 Witold Lojkowski,4 Stefan Tyski,2,5 Agnieszka Mielczarek,6 Pawel Zawadzki1 1Department of Cranio-Maxillofacial Surgery, Oral Surgery and Implantology, Medical University of Warsaw, Warsaw, Poland; 2Department of Anti...

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Autores principales:	Pokrowiecki R, Wojnarowicz J, Zareba T, Koltsov I, Lojkowski W, Tyski S, Mielczarek A, Zawadzki P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	nanomaterials controlled drug release nanoparticles metal nanoparticles bacteria Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/426c32ccbb714de5bd6b3c8719f9b73a
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spelling	oai:doaj.org-article:426c32ccbb714de5bd6b3c8719f9b73a2021-12-02T04:36:09ZNanoparticles And Human Saliva: A Step Towards Drug Delivery Systems For Dental And Craniofacial Biomaterials1178-2013https://doaj.org/article/426c32ccbb714de5bd6b3c8719f9b73a2019-11-01T00:00:00Zhttps://www.dovepress.com/nanoparticles-and-human-saliva-a-step-towards-drug-delivery-systems-fo-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Rafal Pokrowiecki,1–3 Jacek Wojnarowicz,4 Tomasz Zareba,2 Iwona Koltsov,4 Witold Lojkowski,4 Stefan Tyski,2,5 Agnieszka Mielczarek,6 Pawel Zawadzki1 1Department of Cranio-Maxillofacial Surgery, Oral Surgery and Implantology, Medical University of Warsaw, Warsaw, Poland; 2Department of Antibiotics and Microbiology, National Medicines Institute, Warsaw, Poland; 3Private Practice, Warsaw, Poland; 4Institute of High Pressure Physics, Polish Academy of Sciences, Warsaw, Poland; 5Department of Pharmaceutical Microbiology, Medical University of Warsaw, Warsaw, Poland; 6Department of Conservative Dentistry, Medical University of Warsaw, Warsaw, PolandCorrespondence: Agnieszka MielczarekDepartment of Conservative Dentistry, Medical University of Warsaw, Binieckiego 6, Warsaw 02-097, PolandTel +48 22 116 6446Fax +48 572 0154Email sekretariat.zachowawcza@wum.edu.plAim: The aims of this study were to investigate new nano-formulations based on ZnO and Ag nanoparticle (NP) compounds when used against clinical strains of oral gram-positive and gram-negative bacteria, and to examine the stability and behaviour of nano-formulation mixtures in saliva based on different compositions of Ag NPs, ZnO NPs and ZnO+x·Ag NPs. Methods: ZnO NPs with and without nanosilver were obtained by microwave solvothermal synthesis. Then, antibacterial activity was evaluated against bacteria isolated from human saliva. Behavior and nanoparticle solutions were evaluated in human saliva and control (artificial saliva and deionized water). Results were statistically compared. Results: The NP mixtures had an average size of 30±3 nm, while the commercial Ag NPs had an average size of 55±5 nm. The suspensions displayed differing antibacterial activities and kinetics of destabilisation processes, depending on NPs composition and fluid types.Conclusion: The present study showed that all NPs suspensions displayed significant destabilisation and high destabilisation over the 24 h of the analyses. The agglomeration processes of NPs in human saliva can be reversible.Keywords: nanomaterials, controlled drug release, nanoparticles, metal nanoparticles, bacteriaPokrowiecki RWojnarowicz JZareba TKoltsov ILojkowski WTyski SMielczarek AZawadzki PDove Medical Pressarticlenanomaterialscontrolled drug releasenanoparticlesmetal nanoparticlesbacteriaMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 9235-9257 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanomaterials controlled drug release nanoparticles metal nanoparticles bacteria Medicine (General) R5-920
spellingShingle	nanomaterials controlled drug release nanoparticles metal nanoparticles bacteria Medicine (General) R5-920 Pokrowiecki R Wojnarowicz J Zareba T Koltsov I Lojkowski W Tyski S Mielczarek A Zawadzki P Nanoparticles And Human Saliva: A Step Towards Drug Delivery Systems For Dental And Craniofacial Biomaterials
description	Rafal Pokrowiecki,1–3 Jacek Wojnarowicz,4 Tomasz Zareba,2 Iwona Koltsov,4 Witold Lojkowski,4 Stefan Tyski,2,5 Agnieszka Mielczarek,6 Pawel Zawadzki1 1Department of Cranio-Maxillofacial Surgery, Oral Surgery and Implantology, Medical University of Warsaw, Warsaw, Poland; 2Department of Antibiotics and Microbiology, National Medicines Institute, Warsaw, Poland; 3Private Practice, Warsaw, Poland; 4Institute of High Pressure Physics, Polish Academy of Sciences, Warsaw, Poland; 5Department of Pharmaceutical Microbiology, Medical University of Warsaw, Warsaw, Poland; 6Department of Conservative Dentistry, Medical University of Warsaw, Warsaw, PolandCorrespondence: Agnieszka MielczarekDepartment of Conservative Dentistry, Medical University of Warsaw, Binieckiego 6, Warsaw 02-097, PolandTel +48 22 116 6446Fax +48 572 0154Email sekretariat.zachowawcza@wum.edu.plAim: The aims of this study were to investigate new nano-formulations based on ZnO and Ag nanoparticle (NP) compounds when used against clinical strains of oral gram-positive and gram-negative bacteria, and to examine the stability and behaviour of nano-formulation mixtures in saliva based on different compositions of Ag NPs, ZnO NPs and ZnO+x·Ag NPs. Methods: ZnO NPs with and without nanosilver were obtained by microwave solvothermal synthesis. Then, antibacterial activity was evaluated against bacteria isolated from human saliva. Behavior and nanoparticle solutions were evaluated in human saliva and control (artificial saliva and deionized water). Results were statistically compared. Results: The NP mixtures had an average size of 30±3 nm, while the commercial Ag NPs had an average size of 55±5 nm. The suspensions displayed differing antibacterial activities and kinetics of destabilisation processes, depending on NPs composition and fluid types.Conclusion: The present study showed that all NPs suspensions displayed significant destabilisation and high destabilisation over the 24 h of the analyses. The agglomeration processes of NPs in human saliva can be reversible.Keywords: nanomaterials, controlled drug release, nanoparticles, metal nanoparticles, bacteria
format	article
author	Pokrowiecki R Wojnarowicz J Zareba T Koltsov I Lojkowski W Tyski S Mielczarek A Zawadzki P
author_facet	Pokrowiecki R Wojnarowicz J Zareba T Koltsov I Lojkowski W Tyski S Mielczarek A Zawadzki P
author_sort	Pokrowiecki R
title	Nanoparticles And Human Saliva: A Step Towards Drug Delivery Systems For Dental And Craniofacial Biomaterials
title_short	Nanoparticles And Human Saliva: A Step Towards Drug Delivery Systems For Dental And Craniofacial Biomaterials
title_full	Nanoparticles And Human Saliva: A Step Towards Drug Delivery Systems For Dental And Craniofacial Biomaterials
title_fullStr	Nanoparticles And Human Saliva: A Step Towards Drug Delivery Systems For Dental And Craniofacial Biomaterials
title_full_unstemmed	Nanoparticles And Human Saliva: A Step Towards Drug Delivery Systems For Dental And Craniofacial Biomaterials
title_sort	nanoparticles and human saliva: a step towards drug delivery systems for dental and craniofacial biomaterials
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/426c32ccbb714de5bd6b3c8719f9b73a
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Nanoparticles And Human Saliva: A Step Towards Drug Delivery Systems For Dental And Craniofacial Biomaterials

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