Perilipin 5 links mitochondrial uncoupled respiration in brown fat to healthy white fat remodeling and systemic glucose tolerance

Perilipin 5 is a lipid droplet protein that interacts with PGC1α in the nucleus to regulate mitochondrial metabolism. Here the authors use genetically engineered mouse models to determine the physiologic role of Perilipin 5, and show that it regulates mitochondrial adaptations to cold, as well as sy...

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Autores principales:	Violeta I. Gallardo-Montejano, Chaofeng Yang, Lisa Hahner, John L. McAfee, Joshua A. Johnson, William L. Holland, Rodrigo Fernandez-Valdivia, Perry E. Bickel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/426dad6676c648f19a1b00f70052ac14
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spelling	oai:doaj.org-article:426dad6676c648f19a1b00f70052ac142021-12-02T15:56:54ZPerilipin 5 links mitochondrial uncoupled respiration in brown fat to healthy white fat remodeling and systemic glucose tolerance10.1038/s41467-021-23601-22041-1723https://doaj.org/article/426dad6676c648f19a1b00f70052ac142021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23601-2https://doaj.org/toc/2041-1723Perilipin 5 is a lipid droplet protein that interacts with PGC1α in the nucleus to regulate mitochondrial metabolism. Here the authors use genetically engineered mouse models to determine the physiologic role of Perilipin 5, and show that it regulates mitochondrial adaptations to cold, as well as systemic energy metabolism.Violeta I. Gallardo-MontejanoChaofeng YangLisa HahnerJohn L. McAfeeJoshua A. JohnsonWilliam L. HollandRodrigo Fernandez-ValdiviaPerry E. BickelNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Violeta I. Gallardo-Montejano Chaofeng Yang Lisa Hahner John L. McAfee Joshua A. Johnson William L. Holland Rodrigo Fernandez-Valdivia Perry E. Bickel Perilipin 5 links mitochondrial uncoupled respiration in brown fat to healthy white fat remodeling and systemic glucose tolerance
description	Perilipin 5 is a lipid droplet protein that interacts with PGC1α in the nucleus to regulate mitochondrial metabolism. Here the authors use genetically engineered mouse models to determine the physiologic role of Perilipin 5, and show that it regulates mitochondrial adaptations to cold, as well as systemic energy metabolism.
format	article
author	Violeta I. Gallardo-Montejano Chaofeng Yang Lisa Hahner John L. McAfee Joshua A. Johnson William L. Holland Rodrigo Fernandez-Valdivia Perry E. Bickel
author_facet	Violeta I. Gallardo-Montejano Chaofeng Yang Lisa Hahner John L. McAfee Joshua A. Johnson William L. Holland Rodrigo Fernandez-Valdivia Perry E. Bickel
author_sort	Violeta I. Gallardo-Montejano
title	Perilipin 5 links mitochondrial uncoupled respiration in brown fat to healthy white fat remodeling and systemic glucose tolerance
title_short	Perilipin 5 links mitochondrial uncoupled respiration in brown fat to healthy white fat remodeling and systemic glucose tolerance
title_full	Perilipin 5 links mitochondrial uncoupled respiration in brown fat to healthy white fat remodeling and systemic glucose tolerance
title_fullStr	Perilipin 5 links mitochondrial uncoupled respiration in brown fat to healthy white fat remodeling and systemic glucose tolerance
title_full_unstemmed	Perilipin 5 links mitochondrial uncoupled respiration in brown fat to healthy white fat remodeling and systemic glucose tolerance
title_sort	perilipin 5 links mitochondrial uncoupled respiration in brown fat to healthy white fat remodeling and systemic glucose tolerance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/426dad6676c648f19a1b00f70052ac14
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Perilipin 5 links mitochondrial uncoupled respiration in brown fat to healthy white fat remodeling and systemic glucose tolerance

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