Daily corticosterone rhythm modulates pineal function through NFκB-related gene transcriptional program

Abstract Melatonin and glucocorticoids are key hormones in determining daily rhythmicity and modulating defense responses. In nocturnal animals, corticosterone peaks at light/dark transition,while melatonin peaks at the middle of the night in both nocturnal and diurnal animals. The crosstalk between...

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Autores principales:	Sanseray da Silveira Cruz-Machado, Eduardo K. Tamura, Claudia E. Carvalho-Sousa, Vanderlei Amadeu Rocha, Luciana Pinato, Pedro A. C. Fernandes, Regina P. Markus
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/426dffc13dc244318d7fcd9295dcaa86
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spelling	oai:doaj.org-article:426dffc13dc244318d7fcd9295dcaa862021-12-02T16:06:25ZDaily corticosterone rhythm modulates pineal function through NFκB-related gene transcriptional program10.1038/s41598-017-02286-y2045-2322https://doaj.org/article/426dffc13dc244318d7fcd9295dcaa862017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02286-yhttps://doaj.org/toc/2045-2322Abstract Melatonin and glucocorticoids are key hormones in determining daily rhythmicity and modulating defense responses. In nocturnal animals, corticosterone peaks at light/dark transition,while melatonin peaks at the middle of the night in both nocturnal and diurnal animals. The crosstalk between adrenal and pineal glands under inflammatory conditions indicates that corticosterone potentiates nocturnal melatonin synthesis by reducing the activity of NFκB. This transcription factor, which modulates the expression of a key enzyme in melatonin synthesis, is sharply reduced at the entrance of darkness in the rat pineal gland. In this study, we established the basis for understanding the crosstalk between adrenal and pineal glands in physiological conditions. Here we show that the expression of 70 out of 84 genes implied in defense responses exhibit a sharp reduction exactly at the entrance of darkness. Mifepristone impair the changes of 13 out of 84 genes, suggesting that the rhythm of corticosterone modulates pineal phenotype, as mifepristone also reduces the expression of Aanat and the nocturnal synthesis of melatonin. Therefore, darkness-induced synthesis of the pineal hormone, besides being controlled by the central clock located in the hypothalamus, is also influencedby glucocorticoids through the regulation of NFκB transcriptional program.Sanseray da Silveira Cruz-MachadoEduardo K. TamuraClaudia E. Carvalho-SousaVanderlei Amadeu RochaLuciana PinatoPedro A. C. FernandesRegina P. MarkusNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sanseray da Silveira Cruz-Machado Eduardo K. Tamura Claudia E. Carvalho-Sousa Vanderlei Amadeu Rocha Luciana Pinato Pedro A. C. Fernandes Regina P. Markus Daily corticosterone rhythm modulates pineal function through NFκB-related gene transcriptional program
description	Abstract Melatonin and glucocorticoids are key hormones in determining daily rhythmicity and modulating defense responses. In nocturnal animals, corticosterone peaks at light/dark transition,while melatonin peaks at the middle of the night in both nocturnal and diurnal animals. The crosstalk between adrenal and pineal glands under inflammatory conditions indicates that corticosterone potentiates nocturnal melatonin synthesis by reducing the activity of NFκB. This transcription factor, which modulates the expression of a key enzyme in melatonin synthesis, is sharply reduced at the entrance of darkness in the rat pineal gland. In this study, we established the basis for understanding the crosstalk between adrenal and pineal glands in physiological conditions. Here we show that the expression of 70 out of 84 genes implied in defense responses exhibit a sharp reduction exactly at the entrance of darkness. Mifepristone impair the changes of 13 out of 84 genes, suggesting that the rhythm of corticosterone modulates pineal phenotype, as mifepristone also reduces the expression of Aanat and the nocturnal synthesis of melatonin. Therefore, darkness-induced synthesis of the pineal hormone, besides being controlled by the central clock located in the hypothalamus, is also influencedby glucocorticoids through the regulation of NFκB transcriptional program.
format	article
author	Sanseray da Silveira Cruz-Machado Eduardo K. Tamura Claudia E. Carvalho-Sousa Vanderlei Amadeu Rocha Luciana Pinato Pedro A. C. Fernandes Regina P. Markus
author_facet	Sanseray da Silveira Cruz-Machado Eduardo K. Tamura Claudia E. Carvalho-Sousa Vanderlei Amadeu Rocha Luciana Pinato Pedro A. C. Fernandes Regina P. Markus
author_sort	Sanseray da Silveira Cruz-Machado
title	Daily corticosterone rhythm modulates pineal function through NFκB-related gene transcriptional program
title_short	Daily corticosterone rhythm modulates pineal function through NFκB-related gene transcriptional program
title_full	Daily corticosterone rhythm modulates pineal function through NFκB-related gene transcriptional program
title_fullStr	Daily corticosterone rhythm modulates pineal function through NFκB-related gene transcriptional program
title_full_unstemmed	Daily corticosterone rhythm modulates pineal function through NFκB-related gene transcriptional program
title_sort	daily corticosterone rhythm modulates pineal function through nfκb-related gene transcriptional program
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/426dffc13dc244318d7fcd9295dcaa86
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Daily corticosterone rhythm modulates pineal function through NFκB-related gene transcriptional program

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