Unexpected contribution of fibroblasts to muscle lineage as a mechanism for limb muscle patterning
The dogma is that limb muscle cells originate from somite, while connective tissue fibroblasts derive from lateral plate mesoderm. Here the authors identify a fibroblast population that undergoes myoblast conversion in response to BMP and contributes nuclei to myotubes at the myotendinous junction.
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Nature Portfolio
2021
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oai:doaj.org-article:426e99df6c074d7ca470fa9110de93402021-12-02T17:12:24ZUnexpected contribution of fibroblasts to muscle lineage as a mechanism for limb muscle patterning10.1038/s41467-021-24157-x2041-1723https://doaj.org/article/426e99df6c074d7ca470fa9110de93402021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24157-xhttps://doaj.org/toc/2041-1723The dogma is that limb muscle cells originate from somite, while connective tissue fibroblasts derive from lateral plate mesoderm. Here the authors identify a fibroblast population that undergoes myoblast conversion in response to BMP and contributes nuclei to myotubes at the myotendinous junction.Joana Esteves de LimaCédrine BlavetMarie-Ange BonninEstelle HirsingerGlenda ComaiLaurent YvernogeauMarie-Claire DelfiniLéa BellengerSébastien MellaSonya NassariCatherine RobinRonen SchweitzerClaire Fournier-ThibaultThierry JaffredoShahragim TajbakhshFrédéric RelaixDelphine DuprezNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Joana Esteves de Lima Cédrine Blavet Marie-Ange Bonnin Estelle Hirsinger Glenda Comai Laurent Yvernogeau Marie-Claire Delfini Léa Bellenger Sébastien Mella Sonya Nassari Catherine Robin Ronen Schweitzer Claire Fournier-Thibault Thierry Jaffredo Shahragim Tajbakhsh Frédéric Relaix Delphine Duprez Unexpected contribution of fibroblasts to muscle lineage as a mechanism for limb muscle patterning |
| description |
The dogma is that limb muscle cells originate from somite, while connective tissue fibroblasts derive from lateral plate mesoderm. Here the authors identify a fibroblast population that undergoes myoblast conversion in response to BMP and contributes nuclei to myotubes at the myotendinous junction. |
| format |
article |
| author |
Joana Esteves de Lima Cédrine Blavet Marie-Ange Bonnin Estelle Hirsinger Glenda Comai Laurent Yvernogeau Marie-Claire Delfini Léa Bellenger Sébastien Mella Sonya Nassari Catherine Robin Ronen Schweitzer Claire Fournier-Thibault Thierry Jaffredo Shahragim Tajbakhsh Frédéric Relaix Delphine Duprez |
| author_facet |
Joana Esteves de Lima Cédrine Blavet Marie-Ange Bonnin Estelle Hirsinger Glenda Comai Laurent Yvernogeau Marie-Claire Delfini Léa Bellenger Sébastien Mella Sonya Nassari Catherine Robin Ronen Schweitzer Claire Fournier-Thibault Thierry Jaffredo Shahragim Tajbakhsh Frédéric Relaix Delphine Duprez |
| author_sort |
Joana Esteves de Lima |
| title |
Unexpected contribution of fibroblasts to muscle lineage as a mechanism for limb muscle patterning |
| title_short |
Unexpected contribution of fibroblasts to muscle lineage as a mechanism for limb muscle patterning |
| title_full |
Unexpected contribution of fibroblasts to muscle lineage as a mechanism for limb muscle patterning |
| title_fullStr |
Unexpected contribution of fibroblasts to muscle lineage as a mechanism for limb muscle patterning |
| title_full_unstemmed |
Unexpected contribution of fibroblasts to muscle lineage as a mechanism for limb muscle patterning |
| title_sort |
unexpected contribution of fibroblasts to muscle lineage as a mechanism for limb muscle patterning |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/426e99df6c074d7ca470fa9110de9340 |
| work_keys_str_mv |
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| _version_ |
1718381372927639552 |