COVID-19-Associated Pulmonary Aspergillosis in Patients with Acute Leukemia: A Single-Center Study

Patients with coronavirus disease 19 (COVID-19) have increased susceptibility to secondary respiratory infections including invasive pulmonary aspergillosis (IPA). COVID-19-associated pulmonary aspergillosis (CAPA) is difficult to diagnose and can be associated with increased mortality especially in...

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Autores principales:	Jovan Rajic, Ivana Gmizic, Tara Gunjak, Violeta Milosevic, Nikola Pantic, Nikica Sabljic, Mirjana Mitrovic, Aleksandra Djuric Stefanovic, Ljubica Lazic, Snezana Jovanovic, Ivana Milošević, Aleksandra Barac, Ana Vidovic
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Aspergillus</i> COVID-19 acute leukemia Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/42723c98db0a450c8b220f061e4efa0f
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spelling	oai:doaj.org-article:42723c98db0a450c8b220f061e4efa0f2021-11-25T18:05:29ZCOVID-19-Associated Pulmonary Aspergillosis in Patients with Acute Leukemia: A Single-Center Study10.3390/jof71108902309-608Xhttps://doaj.org/article/42723c98db0a450c8b220f061e4efa0f2021-10-01T00:00:00Zhttps://www.mdpi.com/2309-608X/7/11/890https://doaj.org/toc/2309-608XPatients with coronavirus disease 19 (COVID-19) have increased susceptibility to secondary respiratory infections including invasive pulmonary aspergillosis (IPA). COVID-19-associated pulmonary aspergillosis (CAPA) is difficult to diagnose and can be associated with increased mortality especially in severe immunodeficiency such as hematological malignancies. Our study evaluates IPA in COVID-19 patients defined as COVID-19-CAPA among patients with acute leukemia (AL). A retrospective single-center study analyzed 46 patients with COVID-19 infection and acute leukemia, admitted to the Clinic for Haematology, Clinical Center of Serbia, Belgrade between the 2 April 2020 and 15 May 2021. During hospitalization, all participants were diagnosed with probable IPA according to the previous consensus definitions. Positive serology and galactomannan (GM) detection values in bronchoalveolar lavage (BAL) and serum were used as microbiological criteria. COVID-19 associated probable IPA was found in 22% (9/41) tested patients, where serum GM and IgM anti-<i>Aspergillus</i> antibodies were positive in 12% (5/41) and 10% (4/41) had positive serology for aspergillosis. One patient died while eight recovered during follow-up. Our study showed that COVID-19 might be a risk factor for IPA development in patients with AL. Early diagnosis and prompt treatment are required as reported mortality rates are high.Jovan RajicIvana GmizicTara GunjakVioleta MilosevicNikola PanticNikica SabljicMirjana MitrovicAleksandra Djuric StefanovicLjubica LazicSnezana JovanovicIvana MiloševićAleksandra BaracAna VidovicMDPI AGarticle<i>Aspergillus</i>COVID-19acute leukemiaBiology (General)QH301-705.5ENJournal of Fungi, Vol 7, Iss 890, p 890 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Aspergillus</i> COVID-19 acute leukemia Biology (General) QH301-705.5
spellingShingle	<i>Aspergillus</i> COVID-19 acute leukemia Biology (General) QH301-705.5 Jovan Rajic Ivana Gmizic Tara Gunjak Violeta Milosevic Nikola Pantic Nikica Sabljic Mirjana Mitrovic Aleksandra Djuric Stefanovic Ljubica Lazic Snezana Jovanovic Ivana Milošević Aleksandra Barac Ana Vidovic COVID-19-Associated Pulmonary Aspergillosis in Patients with Acute Leukemia: A Single-Center Study
description	Patients with coronavirus disease 19 (COVID-19) have increased susceptibility to secondary respiratory infections including invasive pulmonary aspergillosis (IPA). COVID-19-associated pulmonary aspergillosis (CAPA) is difficult to diagnose and can be associated with increased mortality especially in severe immunodeficiency such as hematological malignancies. Our study evaluates IPA in COVID-19 patients defined as COVID-19-CAPA among patients with acute leukemia (AL). A retrospective single-center study analyzed 46 patients with COVID-19 infection and acute leukemia, admitted to the Clinic for Haematology, Clinical Center of Serbia, Belgrade between the 2 April 2020 and 15 May 2021. During hospitalization, all participants were diagnosed with probable IPA according to the previous consensus definitions. Positive serology and galactomannan (GM) detection values in bronchoalveolar lavage (BAL) and serum were used as microbiological criteria. COVID-19 associated probable IPA was found in 22% (9/41) tested patients, where serum GM and IgM anti-<i>Aspergillus</i> antibodies were positive in 12% (5/41) and 10% (4/41) had positive serology for aspergillosis. One patient died while eight recovered during follow-up. Our study showed that COVID-19 might be a risk factor for IPA development in patients with AL. Early diagnosis and prompt treatment are required as reported mortality rates are high.
format	article
author	Jovan Rajic Ivana Gmizic Tara Gunjak Violeta Milosevic Nikola Pantic Nikica Sabljic Mirjana Mitrovic Aleksandra Djuric Stefanovic Ljubica Lazic Snezana Jovanovic Ivana Milošević Aleksandra Barac Ana Vidovic
author_facet	Jovan Rajic Ivana Gmizic Tara Gunjak Violeta Milosevic Nikola Pantic Nikica Sabljic Mirjana Mitrovic Aleksandra Djuric Stefanovic Ljubica Lazic Snezana Jovanovic Ivana Milošević Aleksandra Barac Ana Vidovic
author_sort	Jovan Rajic
title	COVID-19-Associated Pulmonary Aspergillosis in Patients with Acute Leukemia: A Single-Center Study
title_short	COVID-19-Associated Pulmonary Aspergillosis in Patients with Acute Leukemia: A Single-Center Study
title_full	COVID-19-Associated Pulmonary Aspergillosis in Patients with Acute Leukemia: A Single-Center Study
title_fullStr	COVID-19-Associated Pulmonary Aspergillosis in Patients with Acute Leukemia: A Single-Center Study
title_full_unstemmed	COVID-19-Associated Pulmonary Aspergillosis in Patients with Acute Leukemia: A Single-Center Study
title_sort	covid-19-associated pulmonary aspergillosis in patients with acute leukemia: a single-center study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/42723c98db0a450c8b220f061e4efa0f
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COVID-19-Associated Pulmonary Aspergillosis in Patients with Acute Leukemia: A Single-Center Study

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