Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma

Abstract Iron-loaded tumor-associated macrophages (iTAMs) show a pro-inflammatory phenotype, hallmarked by anti-tumorigenic activity and an ability to attenuate tumor growth. Here we explored the relevance of these findings in lung cancer patients by investigating the impact of the iTAM content in t...

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Autores principales:	Carl Maximilian Thielmann, Milene Costa da Silva, Thomas Muley, Michael Meister, Esther Herpel, Martina U. Muckenthaler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4274f63718ba4e60a8a82f6013d9cf9b
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spelling	oai:doaj.org-article:4274f63718ba4e60a8a82f6013d9cf9b2021-12-02T15:09:45ZIron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma10.1038/s41598-019-47833-x2045-2322https://doaj.org/article/4274f63718ba4e60a8a82f6013d9cf9b2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-47833-xhttps://doaj.org/toc/2045-2322Abstract Iron-loaded tumor-associated macrophages (iTAMs) show a pro-inflammatory phenotype, hallmarked by anti-tumorigenic activity and an ability to attenuate tumor growth. Here we explored the relevance of these findings in lung cancer patients by investigating the impact of the iTAM content in the tumor microenvironment (TME) on patient survival. We analyzed 102 human non-small cell lung cancer (NSCLC) paraffin-embedded archival tissue samples for iron levels and macrophage numbers. Interestingly, patients with lung adenocarcinoma accumulating iron in the TME show higher numbers of M1-like pro-inflammatory TAMs and a survival advantage compared to iron-negative patients. By contrast, in patients with lung squamous cell carcinoma iron in the TME does not affect survival, suggesting a unique influence of iron on different histological subtypes of non-small cell lung cancer (NSCLC). We conclude that in lung adenocarcinoma iron may serve as a prognostic marker for patient survival and as a potential therapeutic target for anti-cancer therapy.Carl Maximilian ThielmannMilene Costa da SilvaThomas MuleyMichael MeisterEsther HerpelMartina U. MuckenthalerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carl Maximilian Thielmann Milene Costa da Silva Thomas Muley Michael Meister Esther Herpel Martina U. Muckenthaler Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma
description	Abstract Iron-loaded tumor-associated macrophages (iTAMs) show a pro-inflammatory phenotype, hallmarked by anti-tumorigenic activity and an ability to attenuate tumor growth. Here we explored the relevance of these findings in lung cancer patients by investigating the impact of the iTAM content in the tumor microenvironment (TME) on patient survival. We analyzed 102 human non-small cell lung cancer (NSCLC) paraffin-embedded archival tissue samples for iron levels and macrophage numbers. Interestingly, patients with lung adenocarcinoma accumulating iron in the TME show higher numbers of M1-like pro-inflammatory TAMs and a survival advantage compared to iron-negative patients. By contrast, in patients with lung squamous cell carcinoma iron in the TME does not affect survival, suggesting a unique influence of iron on different histological subtypes of non-small cell lung cancer (NSCLC). We conclude that in lung adenocarcinoma iron may serve as a prognostic marker for patient survival and as a potential therapeutic target for anti-cancer therapy.
format	article
author	Carl Maximilian Thielmann Milene Costa da Silva Thomas Muley Michael Meister Esther Herpel Martina U. Muckenthaler
author_facet	Carl Maximilian Thielmann Milene Costa da Silva Thomas Muley Michael Meister Esther Herpel Martina U. Muckenthaler
author_sort	Carl Maximilian Thielmann
title	Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma
title_short	Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma
title_full	Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma
title_fullStr	Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma
title_full_unstemmed	Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma
title_sort	iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4274f63718ba4e60a8a82f6013d9cf9b
work_keys_str_mv	AT carlmaximilianthielmann ironaccumulationintumorassociatedmacrophagesmarksanimprovedoverallsurvivalinpatientswithlungadenocarcinoma AT milenecostadasilva ironaccumulationintumorassociatedmacrophagesmarksanimprovedoverallsurvivalinpatientswithlungadenocarcinoma AT thomasmuley ironaccumulationintumorassociatedmacrophagesmarksanimprovedoverallsurvivalinpatientswithlungadenocarcinoma AT michaelmeister ironaccumulationintumorassociatedmacrophagesmarksanimprovedoverallsurvivalinpatientswithlungadenocarcinoma AT estherherpel ironaccumulationintumorassociatedmacrophagesmarksanimprovedoverallsurvivalinpatientswithlungadenocarcinoma AT martinaumuckenthaler ironaccumulationintumorassociatedmacrophagesmarksanimprovedoverallsurvivalinpatientswithlungadenocarcinoma
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Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma

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