Dendritic targeting in the leg neuropil of Drosophila: the role of midline signalling molecules in generating a myotopic map.

Neural maps are emergent, highly ordered structures that are essential for organizing and presenting synaptic information. Within the embryonic nervous system of Drosophila motoneuron dendrites are organized topographically as a myotopic map that reflects their pattern of innervation in the muscle f...

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Autores principales:	David J Brierley, Eric Blanc, O Venkateswara Reddy, K Vijayraghavan, Darren W Williams
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/42765f23854043a39d4509b044f12360
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spelling	oai:doaj.org-article:42765f23854043a39d4509b044f123602021-11-25T05:34:02ZDendritic targeting in the leg neuropil of Drosophila: the role of midline signalling molecules in generating a myotopic map.1544-91731545-788510.1371/journal.pbio.1000199https://doaj.org/article/42765f23854043a39d4509b044f123602009-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19771147/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Neural maps are emergent, highly ordered structures that are essential for organizing and presenting synaptic information. Within the embryonic nervous system of Drosophila motoneuron dendrites are organized topographically as a myotopic map that reflects their pattern of innervation in the muscle field. Here we reveal that this fundamental organizational principle exists in adult Drosophila, where the dendrites of leg motoneurons also generate a myotopic map. A single postembryonic neuroblast sequentially generates different leg motoneuron subtypes, starting with those innervating proximal targets and medial neuropil regions and producing progeny that innervate distal muscle targets and lateral neuropil later in the lineage. Thus the cellular distinctions in peripheral targets and central dendritic domains, which make up the myotopic map, are linked to the birth-order of these motoneurons. Our developmental analysis of dendrite growth reveals that this myotopic map is generated by targeting. We demonstrate that the medio-lateral positioning of motoneuron dendrites in the leg neuropil is controlled by the midline signalling systems Slit-Robo and Netrin-Fra. These results reveal that dendritic targeting plays a major role in the formation of myotopic maps and suggests that the coordinate spatial control of both pre- and postsynaptic elements by global neuropilar signals may be an important mechanism for establishing the specificity of synaptic connections.David J BrierleyEric BlancO Venkateswara ReddyK VijayraghavanDarren W WilliamsPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 7, Iss 9, p e1000199 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 David J Brierley Eric Blanc O Venkateswara Reddy K Vijayraghavan Darren W Williams Dendritic targeting in the leg neuropil of Drosophila: the role of midline signalling molecules in generating a myotopic map.
description	Neural maps are emergent, highly ordered structures that are essential for organizing and presenting synaptic information. Within the embryonic nervous system of Drosophila motoneuron dendrites are organized topographically as a myotopic map that reflects their pattern of innervation in the muscle field. Here we reveal that this fundamental organizational principle exists in adult Drosophila, where the dendrites of leg motoneurons also generate a myotopic map. A single postembryonic neuroblast sequentially generates different leg motoneuron subtypes, starting with those innervating proximal targets and medial neuropil regions and producing progeny that innervate distal muscle targets and lateral neuropil later in the lineage. Thus the cellular distinctions in peripheral targets and central dendritic domains, which make up the myotopic map, are linked to the birth-order of these motoneurons. Our developmental analysis of dendrite growth reveals that this myotopic map is generated by targeting. We demonstrate that the medio-lateral positioning of motoneuron dendrites in the leg neuropil is controlled by the midline signalling systems Slit-Robo and Netrin-Fra. These results reveal that dendritic targeting plays a major role in the formation of myotopic maps and suggests that the coordinate spatial control of both pre- and postsynaptic elements by global neuropilar signals may be an important mechanism for establishing the specificity of synaptic connections.
format	article
author	David J Brierley Eric Blanc O Venkateswara Reddy K Vijayraghavan Darren W Williams
author_facet	David J Brierley Eric Blanc O Venkateswara Reddy K Vijayraghavan Darren W Williams
author_sort	David J Brierley
title	Dendritic targeting in the leg neuropil of Drosophila: the role of midline signalling molecules in generating a myotopic map.
title_short	Dendritic targeting in the leg neuropil of Drosophila: the role of midline signalling molecules in generating a myotopic map.
title_full	Dendritic targeting in the leg neuropil of Drosophila: the role of midline signalling molecules in generating a myotopic map.
title_fullStr	Dendritic targeting in the leg neuropil of Drosophila: the role of midline signalling molecules in generating a myotopic map.
title_full_unstemmed	Dendritic targeting in the leg neuropil of Drosophila: the role of midline signalling molecules in generating a myotopic map.
title_sort	dendritic targeting in the leg neuropil of drosophila: the role of midline signalling molecules in generating a myotopic map.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/42765f23854043a39d4509b044f12360
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Dendritic targeting in the leg neuropil of Drosophila: the role of midline signalling molecules in generating a myotopic map.

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