Malignant Peritoneal Mesothelioma With EWSR1-ATF1 Fusion: A Case Report

Malignant mesothelioma with EWSR1-ATF1 fusion is a rare malignancy described in young adults without asbestos exposure. To the best of our knowledge, outcomes to local and systemic therapies for this subtype of malignant mesothelioma have not been described. This case report describes the clinical c...

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Autores principales:	Helen Ke, MBBS (Hons), Anthony J. Gill, AM, MBBS, FRCPA, Catriona McKenzie, MBBS (Hons1), FRCPA, James G. Kench, MBBS, Bsc(Med), FRCPA, Renee C.F. Chan, MBBS(Hons1), FRCPA, Nick Pavlakis, BSc, MBBS, MMed(Clin. Epi), PhD, FRACP, Michael Fulham, MBBS(Hons), FRACP, Cherry Koh, MBBS (Hons), MS, FRACS, Steven Kao, BHB, MBChB, PhD, FRACP
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Case report Peritoneal mesothelioma EWSR1 ATF1 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/4276d0c706c24f83ba19a45b265d9305
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spelling	oai:doaj.org-article:4276d0c706c24f83ba19a45b265d93052021-12-02T05:03:45ZMalignant Peritoneal Mesothelioma With EWSR1-ATF1 Fusion: A Case Report2666-364310.1016/j.jtocrr.2021.100236https://doaj.org/article/4276d0c706c24f83ba19a45b265d93052021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666364321000953https://doaj.org/toc/2666-3643Malignant mesothelioma with EWSR1-ATF1 fusion is a rare malignancy described in young adults without asbestos exposure. To the best of our knowledge, outcomes to local and systemic therapies for this subtype of malignant mesothelioma have not been described. This case report describes the clinical course of a 19-year-old man diagnosed with malignant peritoneal mesothelioma with EWSR1-ATF1 fusion localized to the abdomen. His disease followed an aggressive course and resulted in limited survival (18 mo). There was treatment resistance to several lines of conventional local and systemic treatments for peritoneal mesothelioma and biologically targeted MET inhibition with crizotinib. More research is required in this rare subtype of peritoneal mesothelioma.Helen Ke, MBBS (Hons)Anthony J. Gill, AM, MBBS, FRCPACatriona McKenzie, MBBS (Hons1), FRCPAJames G. Kench, MBBS, Bsc(Med), FRCPARenee C.F. Chan, MBBS(Hons1), FRCPANick Pavlakis, BSc, MBBS, MMed(Clin. Epi), PhD, FRACPMichael Fulham, MBBS(Hons), FRACPCherry Koh, MBBS (Hons), MS, FRACSSteven Kao, BHB, MBChB, PhD, FRACPElsevierarticleCase reportPeritoneal mesotheliomaEWSR1ATF1Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENJTO Clinical and Research Reports, Vol 2, Iss 11, Pp 100236- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Case report Peritoneal mesothelioma EWSR1 ATF1 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Case report Peritoneal mesothelioma EWSR1 ATF1 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Helen Ke, MBBS (Hons) Anthony J. Gill, AM, MBBS, FRCPA Catriona McKenzie, MBBS (Hons1), FRCPA James G. Kench, MBBS, Bsc(Med), FRCPA Renee C.F. Chan, MBBS(Hons1), FRCPA Nick Pavlakis, BSc, MBBS, MMed(Clin. Epi), PhD, FRACP Michael Fulham, MBBS(Hons), FRACP Cherry Koh, MBBS (Hons), MS, FRACS Steven Kao, BHB, MBChB, PhD, FRACP Malignant Peritoneal Mesothelioma With EWSR1-ATF1 Fusion: A Case Report
description	Malignant mesothelioma with EWSR1-ATF1 fusion is a rare malignancy described in young adults without asbestos exposure. To the best of our knowledge, outcomes to local and systemic therapies for this subtype of malignant mesothelioma have not been described. This case report describes the clinical course of a 19-year-old man diagnosed with malignant peritoneal mesothelioma with EWSR1-ATF1 fusion localized to the abdomen. His disease followed an aggressive course and resulted in limited survival (18 mo). There was treatment resistance to several lines of conventional local and systemic treatments for peritoneal mesothelioma and biologically targeted MET inhibition with crizotinib. More research is required in this rare subtype of peritoneal mesothelioma.
format	article
author	Helen Ke, MBBS (Hons) Anthony J. Gill, AM, MBBS, FRCPA Catriona McKenzie, MBBS (Hons1), FRCPA James G. Kench, MBBS, Bsc(Med), FRCPA Renee C.F. Chan, MBBS(Hons1), FRCPA Nick Pavlakis, BSc, MBBS, MMed(Clin. Epi), PhD, FRACP Michael Fulham, MBBS(Hons), FRACP Cherry Koh, MBBS (Hons), MS, FRACS Steven Kao, BHB, MBChB, PhD, FRACP
author_facet	Helen Ke, MBBS (Hons) Anthony J. Gill, AM, MBBS, FRCPA Catriona McKenzie, MBBS (Hons1), FRCPA James G. Kench, MBBS, Bsc(Med), FRCPA Renee C.F. Chan, MBBS(Hons1), FRCPA Nick Pavlakis, BSc, MBBS, MMed(Clin. Epi), PhD, FRACP Michael Fulham, MBBS(Hons), FRACP Cherry Koh, MBBS (Hons), MS, FRACS Steven Kao, BHB, MBChB, PhD, FRACP
author_sort	Helen Ke, MBBS (Hons)
title	Malignant Peritoneal Mesothelioma With EWSR1-ATF1 Fusion: A Case Report
title_short	Malignant Peritoneal Mesothelioma With EWSR1-ATF1 Fusion: A Case Report
title_full	Malignant Peritoneal Mesothelioma With EWSR1-ATF1 Fusion: A Case Report
title_fullStr	Malignant Peritoneal Mesothelioma With EWSR1-ATF1 Fusion: A Case Report
title_full_unstemmed	Malignant Peritoneal Mesothelioma With EWSR1-ATF1 Fusion: A Case Report
title_sort	malignant peritoneal mesothelioma with ewsr1-atf1 fusion: a case report
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/4276d0c706c24f83ba19a45b265d9305
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Malignant Peritoneal Mesothelioma With EWSR1-ATF1 Fusion: A Case Report

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