Oxidative Stress Biomarkers as a Predictor of Stage Illness and Clinical Course of Schizophrenia

Pro/antioxidant imbalance has been reported in schizophrenia (SZ). However, the results of studies are inconsistent and usually do not include other factors that are highly affected by oxidative stress (OS).This cross-sectional study aimed to determine the serum levels of OS markers and their potent...

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Autores principales:	Dariusz Juchnowicz, Michał Dzikowski, Joanna Rog, Napoleon Waszkiewicz, Anna Zalewska, Mateusz Maciejczyk, Hanna Karakuła-Juchnowicz
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	schizophrenia oxidative stress antioxidant psychosis biomarkers Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/4278a9a79116464aadb08c890d7f7763
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spelling	oai:doaj.org-article:4278a9a79116464aadb08c890d7f77632021-11-15T06:45:51ZOxidative Stress Biomarkers as a Predictor of Stage Illness and Clinical Course of Schizophrenia1664-064010.3389/fpsyt.2021.728986https://doaj.org/article/4278a9a79116464aadb08c890d7f77632021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.728986/fullhttps://doaj.org/toc/1664-0640Pro/antioxidant imbalance has been reported in schizophrenia (SZ). However, the results of studies are inconsistent and usually do not include other factors that are highly affected by oxidative stress (OS).This cross-sectional study aimed to determine the serum levels of OS markers and their potential connection with schizophrenia. The total sample comprised 147: 98 individuals with SZ −47 first-episode (FS) and 49 chronic patients (CS)—and 49 healthy individuals (HC) as a control group. The examination included clinical variables and serum levels of antioxidants and oxidative damage products. The significant changes were observed in concentrations of all examined markers, without any specific direction of the pro/antioxidant balance shift between SZ and HC. In the regression model adjusted for cofounders, catalase: OR = 0.81 (95%CI: 0.74–0.88); glutathione peroxidase: OR = 1.06 (95%CI: 1.02–1.10); total antioxidant capacity: OR = 0.85 (95%CI: 0.75–0.98); oxidative stress index: OR = 1.25 (95%CI: 1.03–1.52); ferric reducing ability of plasma: OR = 0.79 (95%CI: 0.69–0.89); advanced glycation end products: OR = 1.03 (95%CI: 1.01–1.04); and advanced oxidation protein products (AOPP): OR = 1.05 (95%CI: 1.03–1.07) turned out to be significant predictors of schizophrenia. In the multiple stepwise regression model, pro/antioxidant status and their interaction with the duration of illness-related factors affected schizophrenia symptoms: positive symptoms (FRAPxKYN), negative (DITYR, FRAP, CAT), general (KYN), and over-all psychopathology (KYNxNFK). The results confirm differences in serum levels of oxidative biomarkers between SZ patients and healthy individuals. The pro/antioxidant status could be considered a predictor of schizophrenia and the factor affects patients' symptom severity.Dariusz JuchnowiczMichał DzikowskiJoanna RogNapoleon WaszkiewiczAnna ZalewskaMateusz MaciejczykHanna Karakuła-JuchnowiczFrontiers Media S.A.articleschizophreniaoxidative stressantioxidantpsychosisbiomarkersPsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	schizophrenia oxidative stress antioxidant psychosis biomarkers Psychiatry RC435-571
spellingShingle	schizophrenia oxidative stress antioxidant psychosis biomarkers Psychiatry RC435-571 Dariusz Juchnowicz Michał Dzikowski Joanna Rog Napoleon Waszkiewicz Anna Zalewska Mateusz Maciejczyk Hanna Karakuła-Juchnowicz Oxidative Stress Biomarkers as a Predictor of Stage Illness and Clinical Course of Schizophrenia
description	Pro/antioxidant imbalance has been reported in schizophrenia (SZ). However, the results of studies are inconsistent and usually do not include other factors that are highly affected by oxidative stress (OS).This cross-sectional study aimed to determine the serum levels of OS markers and their potential connection with schizophrenia. The total sample comprised 147: 98 individuals with SZ −47 first-episode (FS) and 49 chronic patients (CS)—and 49 healthy individuals (HC) as a control group. The examination included clinical variables and serum levels of antioxidants and oxidative damage products. The significant changes were observed in concentrations of all examined markers, without any specific direction of the pro/antioxidant balance shift between SZ and HC. In the regression model adjusted for cofounders, catalase: OR = 0.81 (95%CI: 0.74–0.88); glutathione peroxidase: OR = 1.06 (95%CI: 1.02–1.10); total antioxidant capacity: OR = 0.85 (95%CI: 0.75–0.98); oxidative stress index: OR = 1.25 (95%CI: 1.03–1.52); ferric reducing ability of plasma: OR = 0.79 (95%CI: 0.69–0.89); advanced glycation end products: OR = 1.03 (95%CI: 1.01–1.04); and advanced oxidation protein products (AOPP): OR = 1.05 (95%CI: 1.03–1.07) turned out to be significant predictors of schizophrenia. In the multiple stepwise regression model, pro/antioxidant status and their interaction with the duration of illness-related factors affected schizophrenia symptoms: positive symptoms (FRAPxKYN), negative (DITYR, FRAP, CAT), general (KYN), and over-all psychopathology (KYNxNFK). The results confirm differences in serum levels of oxidative biomarkers between SZ patients and healthy individuals. The pro/antioxidant status could be considered a predictor of schizophrenia and the factor affects patients' symptom severity.
format	article
author	Dariusz Juchnowicz Michał Dzikowski Joanna Rog Napoleon Waszkiewicz Anna Zalewska Mateusz Maciejczyk Hanna Karakuła-Juchnowicz
author_facet	Dariusz Juchnowicz Michał Dzikowski Joanna Rog Napoleon Waszkiewicz Anna Zalewska Mateusz Maciejczyk Hanna Karakuła-Juchnowicz
author_sort	Dariusz Juchnowicz
title	Oxidative Stress Biomarkers as a Predictor of Stage Illness and Clinical Course of Schizophrenia
title_short	Oxidative Stress Biomarkers as a Predictor of Stage Illness and Clinical Course of Schizophrenia
title_full	Oxidative Stress Biomarkers as a Predictor of Stage Illness and Clinical Course of Schizophrenia
title_fullStr	Oxidative Stress Biomarkers as a Predictor of Stage Illness and Clinical Course of Schizophrenia
title_full_unstemmed	Oxidative Stress Biomarkers as a Predictor of Stage Illness and Clinical Course of Schizophrenia
title_sort	oxidative stress biomarkers as a predictor of stage illness and clinical course of schizophrenia
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4278a9a79116464aadb08c890d7f7763
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Oxidative Stress Biomarkers as a Predictor of Stage Illness and Clinical Course of Schizophrenia

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