Disseminate Recurrent Folliculitis and Hidradenitis Suppurativa Are Associated Conditions: Results From a Retrospective Study of 131 Patients With Down Syndrome and a Cohort of 12,351 Pediatric Controls

Background: Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent skin disease of the pilosebaceous unit characterized by protean manifestations. Several studies have found an increased incidence and earlier presentation of this disease in patients carrying trisomy 21. Patients with Do...

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Autores principales:	Andrea Sechi, Alba Guglielmo, Annalisa Patrizi, Francesco Savoia, Guido Cocchi, Miriam Leuzzi, Marco A. Chessa, Annalucia Virdi, Iria Neri
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2019
Materias:	hidradinitis suppurativa folliculitis Down syndrome pediatric hair follicle disease Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/427b8f08d559491b8c1f0c26903e9ea9
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spelling	oai:doaj.org-article:427b8f08d559491b8c1f0c26903e9ea92021-11-17T08:29:19ZDisseminate Recurrent Folliculitis and Hidradenitis Suppurativa Are Associated Conditions: Results From a Retrospective Study of 131 Patients With Down Syndrome and a Cohort of 12,351 Pediatric Controls10.5826/dpc.0903a032160-9381https://doaj.org/article/427b8f08d559491b8c1f0c26903e9ea92019-07-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/711https://doaj.org/toc/2160-9381Background: Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent skin disease of the pilosebaceous unit characterized by protean manifestations. Several studies have found an increased incidence and earlier presentation of this disease in patients carrying trisomy 21. Patients with Down syndrome (DS) have a higher risk of developing a wide range of cutaneous manifestations, including HS and chronic folliculitis. Recently, disseminate recurrent folliculitis (DRF) has been reported as an atypical monosymptomatic feature of HS at its onset. Objective: To assess the prevalence of HS and DRF by comparing a cohort of patients carrying trisomy 21 vs pediatric controls. Methods: A retrospective 2-year monocentric clinical study was performed by collecting clinical data of 131 patients with DS, aged 4-36 years, followed at the Dermatology Unit and Down Syndrome Regional Center of Bologna University. Data were matched with those coming from 12,351 pediatric controls. Results: In DS patients, DRF and HS showed a prevalence of, respectively, 6.8% and 24.4%, while 5.3% of patients presented both diseases. In the control group the prevalence for HS+ and DRF+ was 0.5% and 1.2%, respectively, with a 0.14% of overlap cases. The association between HS and DRF proved to be statistically significant in both groups (P < 0.05). In the DS cohort the mean age of symptoms onset was 15.67 (SD: 2.29) years for HS and 13.11 (SD: 4.93) years for DRF. Buttocks were the most frequently affected body area for DRF followed by the inguinocrural area, while in HS buttocks were less frequently involved than groins and upper thighs. Conclusions: Because of the later onset of HS, patients with DRF at an early age should be monitored for the possible onset of HS in the apocrine-bearing areas. Andrea SechiAlba GuglielmoAnnalisa PatriziFrancesco SavoiaGuido CocchiMiriam LeuzziMarco A. ChessaAnnalucia VirdiIria NeriMattioli1885articlehidradinitis suppurativafolliculitisDown syndromepediatrichair follicle diseaseDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 9, Iss 2 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	hidradinitis suppurativa folliculitis Down syndrome pediatric hair follicle disease Dermatology RL1-803
spellingShingle	hidradinitis suppurativa folliculitis Down syndrome pediatric hair follicle disease Dermatology RL1-803 Andrea Sechi Alba Guglielmo Annalisa Patrizi Francesco Savoia Guido Cocchi Miriam Leuzzi Marco A. Chessa Annalucia Virdi Iria Neri Disseminate Recurrent Folliculitis and Hidradenitis Suppurativa Are Associated Conditions: Results From a Retrospective Study of 131 Patients With Down Syndrome and a Cohort of 12,351 Pediatric Controls
description	Background: Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent skin disease of the pilosebaceous unit characterized by protean manifestations. Several studies have found an increased incidence and earlier presentation of this disease in patients carrying trisomy 21. Patients with Down syndrome (DS) have a higher risk of developing a wide range of cutaneous manifestations, including HS and chronic folliculitis. Recently, disseminate recurrent folliculitis (DRF) has been reported as an atypical monosymptomatic feature of HS at its onset. Objective: To assess the prevalence of HS and DRF by comparing a cohort of patients carrying trisomy 21 vs pediatric controls. Methods: A retrospective 2-year monocentric clinical study was performed by collecting clinical data of 131 patients with DS, aged 4-36 years, followed at the Dermatology Unit and Down Syndrome Regional Center of Bologna University. Data were matched with those coming from 12,351 pediatric controls. Results: In DS patients, DRF and HS showed a prevalence of, respectively, 6.8% and 24.4%, while 5.3% of patients presented both diseases. In the control group the prevalence for HS+ and DRF+ was 0.5% and 1.2%, respectively, with a 0.14% of overlap cases. The association between HS and DRF proved to be statistically significant in both groups (P < 0.05). In the DS cohort the mean age of symptoms onset was 15.67 (SD: 2.29) years for HS and 13.11 (SD: 4.93) years for DRF. Buttocks were the most frequently affected body area for DRF followed by the inguinocrural area, while in HS buttocks were less frequently involved than groins and upper thighs. Conclusions: Because of the later onset of HS, patients with DRF at an early age should be monitored for the possible onset of HS in the apocrine-bearing areas.
format	article
author	Andrea Sechi Alba Guglielmo Annalisa Patrizi Francesco Savoia Guido Cocchi Miriam Leuzzi Marco A. Chessa Annalucia Virdi Iria Neri
author_facet	Andrea Sechi Alba Guglielmo Annalisa Patrizi Francesco Savoia Guido Cocchi Miriam Leuzzi Marco A. Chessa Annalucia Virdi Iria Neri
author_sort	Andrea Sechi
title	Disseminate Recurrent Folliculitis and Hidradenitis Suppurativa Are Associated Conditions: Results From a Retrospective Study of 131 Patients With Down Syndrome and a Cohort of 12,351 Pediatric Controls
title_short	Disseminate Recurrent Folliculitis and Hidradenitis Suppurativa Are Associated Conditions: Results From a Retrospective Study of 131 Patients With Down Syndrome and a Cohort of 12,351 Pediatric Controls
title_full	Disseminate Recurrent Folliculitis and Hidradenitis Suppurativa Are Associated Conditions: Results From a Retrospective Study of 131 Patients With Down Syndrome and a Cohort of 12,351 Pediatric Controls
title_fullStr	Disseminate Recurrent Folliculitis and Hidradenitis Suppurativa Are Associated Conditions: Results From a Retrospective Study of 131 Patients With Down Syndrome and a Cohort of 12,351 Pediatric Controls
title_full_unstemmed	Disseminate Recurrent Folliculitis and Hidradenitis Suppurativa Are Associated Conditions: Results From a Retrospective Study of 131 Patients With Down Syndrome and a Cohort of 12,351 Pediatric Controls
title_sort	disseminate recurrent folliculitis and hidradenitis suppurativa are associated conditions: results from a retrospective study of 131 patients with down syndrome and a cohort of 12,351 pediatric controls
publisher	Mattioli1885
publishDate	2019
url	https://doaj.org/article/427b8f08d559491b8c1f0c26903e9ea9
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Disseminate Recurrent Folliculitis and Hidradenitis Suppurativa Are Associated Conditions: Results From a Retrospective Study of 131 Patients With Down Syndrome and a Cohort of 12,351 Pediatric Controls

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