Influence of adult height on rheumatoid arthritis: association with disease activity, impairment of joint function and overall disability.

<h4>Objectives</h4>To investigate whether normal variation of adult height is associated with clinical characteristics in rheumatoid arthritis (RA), including disease activity (DAS28), impairment of joint function (mechanical joint score, MJS) and overall disability (health assessment qu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ying Chen, Zanzhe Yu, Jonathan C Packham, Derek L Mattey
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/427cd3309ff243828a2d3ae090365459
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:427cd3309ff243828a2d3ae090365459
record_format	dspace
spelling	oai:doaj.org-article:427cd3309ff243828a2d3ae0903654592021-11-18T07:45:03ZInfluence of adult height on rheumatoid arthritis: association with disease activity, impairment of joint function and overall disability.1932-620310.1371/journal.pone.0064862https://doaj.org/article/427cd3309ff243828a2d3ae0903654592013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23705017/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>To investigate whether normal variation of adult height is associated with clinical characteristics in rheumatoid arthritis (RA), including disease activity (DAS28), impairment of joint function (mechanical joint score, MJS) and overall disability (health assessment questionnaire, HAQ).<h4>Methods</h4>A cohort (134 males, 287 females) of consecutively recruited RA patients of Northern European origin was studied. Height, weight and demographic information were obtained. A core set of disease measurements, including DAS28, MJS and HAQ, were recorded at baseline, 12 and 24 months. Other clinical variables (e.g. disease duration, IgM rheumatoid factor, antibodies to cyclic citrullinated peptide, C-reactive protein, erythrocyte sedimentation rate) were recorded at baseline. Socioeconomic status, smoking status, comorbid condition, other autoimmune conditions and drug therapy were also recorded. Associations were analyzed using univariate statistics and multivariate linear regression models. Mediation tests were also carried out for evaluating the relationship between gender, height and disease measures.<h4>Results</h4>In males, height was inversely associated with DAS28, MJS and HAQ (at baseline and over 24 months) independent of other factors (e.g. weight, body mass index, age, disease duration, osteoporosis, autoantibodies, erosive disease, joint replacement, steroid use, smoking status, socioeconomic status and comorbid disease). In females, a similar trend was seen but the relationships were non significant. In the whole population, the association of female gender with more active disease and poor function disappeared after adjustment for height. Mediation analysis indicated that height served as a full mediator in the relationship of gender with disease activity and overall disability. Confirmation of these findings was demonstrated in a second RA population (n = 288).<h4>Conclusion</h4>Adult height is inversely associated with disease activity, impairment of joint function and overall disability in RA, particularly in males. The association of female sex with more severe disease activity and disability appears to be mediated by smaller stature.Ying ChenZanzhe YuJonathan C PackhamDerek L MatteyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e64862 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ying Chen Zanzhe Yu Jonathan C Packham Derek L Mattey Influence of adult height on rheumatoid arthritis: association with disease activity, impairment of joint function and overall disability.
description	<h4>Objectives</h4>To investigate whether normal variation of adult height is associated with clinical characteristics in rheumatoid arthritis (RA), including disease activity (DAS28), impairment of joint function (mechanical joint score, MJS) and overall disability (health assessment questionnaire, HAQ).<h4>Methods</h4>A cohort (134 males, 287 females) of consecutively recruited RA patients of Northern European origin was studied. Height, weight and demographic information were obtained. A core set of disease measurements, including DAS28, MJS and HAQ, were recorded at baseline, 12 and 24 months. Other clinical variables (e.g. disease duration, IgM rheumatoid factor, antibodies to cyclic citrullinated peptide, C-reactive protein, erythrocyte sedimentation rate) were recorded at baseline. Socioeconomic status, smoking status, comorbid condition, other autoimmune conditions and drug therapy were also recorded. Associations were analyzed using univariate statistics and multivariate linear regression models. Mediation tests were also carried out for evaluating the relationship between gender, height and disease measures.<h4>Results</h4>In males, height was inversely associated with DAS28, MJS and HAQ (at baseline and over 24 months) independent of other factors (e.g. weight, body mass index, age, disease duration, osteoporosis, autoantibodies, erosive disease, joint replacement, steroid use, smoking status, socioeconomic status and comorbid disease). In females, a similar trend was seen but the relationships were non significant. In the whole population, the association of female gender with more active disease and poor function disappeared after adjustment for height. Mediation analysis indicated that height served as a full mediator in the relationship of gender with disease activity and overall disability. Confirmation of these findings was demonstrated in a second RA population (n = 288).<h4>Conclusion</h4>Adult height is inversely associated with disease activity, impairment of joint function and overall disability in RA, particularly in males. The association of female sex with more severe disease activity and disability appears to be mediated by smaller stature.
format	article
author	Ying Chen Zanzhe Yu Jonathan C Packham Derek L Mattey
author_facet	Ying Chen Zanzhe Yu Jonathan C Packham Derek L Mattey
author_sort	Ying Chen
title	Influence of adult height on rheumatoid arthritis: association with disease activity, impairment of joint function and overall disability.
title_short	Influence of adult height on rheumatoid arthritis: association with disease activity, impairment of joint function and overall disability.
title_full	Influence of adult height on rheumatoid arthritis: association with disease activity, impairment of joint function and overall disability.
title_fullStr	Influence of adult height on rheumatoid arthritis: association with disease activity, impairment of joint function and overall disability.
title_full_unstemmed	Influence of adult height on rheumatoid arthritis: association with disease activity, impairment of joint function and overall disability.
title_sort	influence of adult height on rheumatoid arthritis: association with disease activity, impairment of joint function and overall disability.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/427cd3309ff243828a2d3ae090365459
work_keys_str_mv	AT yingchen influenceofadultheightonrheumatoidarthritisassociationwithdiseaseactivityimpairmentofjointfunctionandoveralldisability AT zanzheyu influenceofadultheightonrheumatoidarthritisassociationwithdiseaseactivityimpairmentofjointfunctionandoveralldisability AT jonathancpackham influenceofadultheightonrheumatoidarthritisassociationwithdiseaseactivityimpairmentofjointfunctionandoveralldisability AT dereklmattey influenceofadultheightonrheumatoidarthritisassociationwithdiseaseactivityimpairmentofjointfunctionandoveralldisability
_version_	1718423031397744640

Influence of adult height on rheumatoid arthritis: association with disease activity, impairment of joint function and overall disability.

Ejemplares similares