Enhanced intestinal 2-deoxy-2-[18F]fluoro-D-glucose uptake under metformin is not fully suppressed by loperamide

Objective. This study investigated whether the metformin (Met)-induced enhanced intestinal uptake of 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) is reduced by loperamide, a long-acting anti-diarrheal agent. Methods. Mean 18F-FDG uptake in the mouse small intestine and colon with Met exposure was compa...

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Autores principales:	Nobashi Tomomi, Saga Tsuneo, Nakamoto Yuji, Shimizu Yoichi, Koyasu Sho, Ishimori Takayoshi, Watanabe Masao, Kimura Hiroyuki, Togashi Kaori
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2018
Materias:	18f-fdg pet/ct metformin loperamide intestine physiological Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/427e471973cc4c0a94fd8ba174835275
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spelling	oai:doaj.org-article:427e471973cc4c0a94fd8ba1748352752021-12-02T19:07:36ZEnhanced intestinal 2-deoxy-2-[18F]fluoro-D-glucose uptake under metformin is not fully suppressed by loperamide1336-032910.2478/enr-2018-0023https://doaj.org/article/427e471973cc4c0a94fd8ba1748352752018-10-01T00:00:00Zhttps://doi.org/10.2478/enr-2018-0023https://doaj.org/toc/1336-0329Objective. This study investigated whether the metformin (Met)-induced enhanced intestinal uptake of 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) is reduced by loperamide, a long-acting anti-diarrheal agent. Methods. Mean 18F-FDG uptake in the mouse small intestine and colon with Met exposure was compared with that in control mice. In the Met group, high-dose (1.0 mg/kg body weight) and low-dose (0.1 mg/kg body weight) loperamide were introduced, and 18F-FDG uptake in the small intestine and colon was compared with that of control mice administered high-dose loperamide. The percent injected dose of 18F-FDG per gram of tissue (%ID/g) in the extracted tissues was then determined. Results. 18F-FDG uptake increased significantly in the small intestine (0.64±0.06 vs. 1.01±0.15, p=0.040) and, especially, the colon (0.46±0.13 vs. 2.16±0.51, p<0.001) after Met exposure. Neither high-dose nor low-dose loperamide significantly reduced 18F-FDG uptake in the small intestine (0.82±0.31 vs. 0.84±0.22, p=0.93 and 0.78±0.25 vs. 0.70±0.15, p=0.13, respectively) or colon (2.13±0.41 vs. 1.67±0.55, p=0.063 and 1.77±0.39 vs. 1.80±0.25, p=0.56, respectively). The colonic %ID/g was significantly higher in Met groups irrespective of loperamide introduction than in control group, whereas the significant difference in the small intestine was observed only between Met and control groups. Conclusion. Metformin increased 18F-FDG uptake in intestines especially in colon. Loperamide administration partially, but not sufficiently, suppresses the Met-induced increased colonic uptake of 18F-FDG.Nobashi TomomiSaga TsuneoNakamoto YujiShimizu YoichiKoyasu ShoIshimori TakayoshiWatanabe MasaoKimura HiroyukiTogashi KaoriSciendoarticle18f-fdgpet/ctmetforminloperamideintestinephysiologicalDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 52, Iss 4, Pp 185-191 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	18f-fdg pet/ct metformin loperamide intestine physiological Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	18f-fdg pet/ct metformin loperamide intestine physiological Diseases of the endocrine glands. Clinical endocrinology RC648-665 Nobashi Tomomi Saga Tsuneo Nakamoto Yuji Shimizu Yoichi Koyasu Sho Ishimori Takayoshi Watanabe Masao Kimura Hiroyuki Togashi Kaori Enhanced intestinal 2-deoxy-2-[18F]fluoro-D-glucose uptake under metformin is not fully suppressed by loperamide
description	Objective. This study investigated whether the metformin (Met)-induced enhanced intestinal uptake of 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) is reduced by loperamide, a long-acting anti-diarrheal agent. Methods. Mean 18F-FDG uptake in the mouse small intestine and colon with Met exposure was compared with that in control mice. In the Met group, high-dose (1.0 mg/kg body weight) and low-dose (0.1 mg/kg body weight) loperamide were introduced, and 18F-FDG uptake in the small intestine and colon was compared with that of control mice administered high-dose loperamide. The percent injected dose of 18F-FDG per gram of tissue (%ID/g) in the extracted tissues was then determined. Results. 18F-FDG uptake increased significantly in the small intestine (0.64±0.06 vs. 1.01±0.15, p=0.040) and, especially, the colon (0.46±0.13 vs. 2.16±0.51, p<0.001) after Met exposure. Neither high-dose nor low-dose loperamide significantly reduced 18F-FDG uptake in the small intestine (0.82±0.31 vs. 0.84±0.22, p=0.93 and 0.78±0.25 vs. 0.70±0.15, p=0.13, respectively) or colon (2.13±0.41 vs. 1.67±0.55, p=0.063 and 1.77±0.39 vs. 1.80±0.25, p=0.56, respectively). The colonic %ID/g was significantly higher in Met groups irrespective of loperamide introduction than in control group, whereas the significant difference in the small intestine was observed only between Met and control groups. Conclusion. Metformin increased 18F-FDG uptake in intestines especially in colon. Loperamide administration partially, but not sufficiently, suppresses the Met-induced increased colonic uptake of 18F-FDG.
format	article
author	Nobashi Tomomi Saga Tsuneo Nakamoto Yuji Shimizu Yoichi Koyasu Sho Ishimori Takayoshi Watanabe Masao Kimura Hiroyuki Togashi Kaori
author_facet	Nobashi Tomomi Saga Tsuneo Nakamoto Yuji Shimizu Yoichi Koyasu Sho Ishimori Takayoshi Watanabe Masao Kimura Hiroyuki Togashi Kaori
author_sort	Nobashi Tomomi
title	Enhanced intestinal 2-deoxy-2-[18F]fluoro-D-glucose uptake under metformin is not fully suppressed by loperamide
title_short	Enhanced intestinal 2-deoxy-2-[18F]fluoro-D-glucose uptake under metformin is not fully suppressed by loperamide
title_full	Enhanced intestinal 2-deoxy-2-[18F]fluoro-D-glucose uptake under metformin is not fully suppressed by loperamide
title_fullStr	Enhanced intestinal 2-deoxy-2-[18F]fluoro-D-glucose uptake under metformin is not fully suppressed by loperamide
title_full_unstemmed	Enhanced intestinal 2-deoxy-2-[18F]fluoro-D-glucose uptake under metformin is not fully suppressed by loperamide
title_sort	enhanced intestinal 2-deoxy-2-[18f]fluoro-d-glucose uptake under metformin is not fully suppressed by loperamide
publisher	Sciendo
publishDate	2018
url	https://doaj.org/article/427e471973cc4c0a94fd8ba174835275
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Enhanced intestinal 2-deoxy-2-[18F]fluoro-D-glucose uptake under metformin is not fully suppressed by loperamide

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