Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

Glutamine can feed into the TCA cycle as a fuel for oxidative phosphorylation and thereby can affect metabolic pathways in lymphocytes. Yet here the authors show that glutamine serves predominantly as a signalling molecule that sustains cMyc expression to control NK cell metabolism and effector func...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Róisín M. Loftus, Nadine Assmann, Nidhi Kedia-Mehta, Katie L. O’Brien, Arianne Garcia, Conor Gillespie, Jens L. Hukelmann, Peter J. Oefner, Angus I. Lamond, Clair M. Gardiner, Katja Dettmer, Doreen A. Cantrell, Linda V. Sinclair, David K. Finlay
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/428103db6a8c40348a0ae092d9d2a982
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:428103db6a8c40348a0ae092d9d2a982
record_format dspace
spelling oai:doaj.org-article:428103db6a8c40348a0ae092d9d2a9822021-12-02T15:34:23ZAmino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice10.1038/s41467-018-04719-22041-1723https://doaj.org/article/428103db6a8c40348a0ae092d9d2a9822018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04719-2https://doaj.org/toc/2041-1723Glutamine can feed into the TCA cycle as a fuel for oxidative phosphorylation and thereby can affect metabolic pathways in lymphocytes. Yet here the authors show that glutamine serves predominantly as a signalling molecule that sustains cMyc expression to control NK cell metabolism and effector function.Róisín M. LoftusNadine AssmannNidhi Kedia-MehtaKatie L. O’BrienArianne GarciaConor GillespieJens L. HukelmannPeter J. OefnerAngus I. LamondClair M. GardinerKatja DettmerDoreen A. CantrellLinda V. SinclairDavid K. FinlayNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Róisín M. Loftus
Nadine Assmann
Nidhi Kedia-Mehta
Katie L. O’Brien
Arianne Garcia
Conor Gillespie
Jens L. Hukelmann
Peter J. Oefner
Angus I. Lamond
Clair M. Gardiner
Katja Dettmer
Doreen A. Cantrell
Linda V. Sinclair
David K. Finlay
Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice
description Glutamine can feed into the TCA cycle as a fuel for oxidative phosphorylation and thereby can affect metabolic pathways in lymphocytes. Yet here the authors show that glutamine serves predominantly as a signalling molecule that sustains cMyc expression to control NK cell metabolism and effector function.
format article
author Róisín M. Loftus
Nadine Assmann
Nidhi Kedia-Mehta
Katie L. O’Brien
Arianne Garcia
Conor Gillespie
Jens L. Hukelmann
Peter J. Oefner
Angus I. Lamond
Clair M. Gardiner
Katja Dettmer
Doreen A. Cantrell
Linda V. Sinclair
David K. Finlay
author_facet Róisín M. Loftus
Nadine Assmann
Nidhi Kedia-Mehta
Katie L. O’Brien
Arianne Garcia
Conor Gillespie
Jens L. Hukelmann
Peter J. Oefner
Angus I. Lamond
Clair M. Gardiner
Katja Dettmer
Doreen A. Cantrell
Linda V. Sinclair
David K. Finlay
author_sort Róisín M. Loftus
title Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice
title_short Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice
title_full Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice
title_fullStr Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice
title_full_unstemmed Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice
title_sort amino acid-dependent cmyc expression is essential for nk cell metabolic and functional responses in mice
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/428103db6a8c40348a0ae092d9d2a982
work_keys_str_mv AT roisinmloftus aminoaciddependentcmycexpressionisessentialfornkcellmetabolicandfunctionalresponsesinmice
AT nadineassmann aminoaciddependentcmycexpressionisessentialfornkcellmetabolicandfunctionalresponsesinmice
AT nidhikediamehta aminoaciddependentcmycexpressionisessentialfornkcellmetabolicandfunctionalresponsesinmice
AT katielobrien aminoaciddependentcmycexpressionisessentialfornkcellmetabolicandfunctionalresponsesinmice
AT ariannegarcia aminoaciddependentcmycexpressionisessentialfornkcellmetabolicandfunctionalresponsesinmice
AT conorgillespie aminoaciddependentcmycexpressionisessentialfornkcellmetabolicandfunctionalresponsesinmice
AT jenslhukelmann aminoaciddependentcmycexpressionisessentialfornkcellmetabolicandfunctionalresponsesinmice
AT peterjoefner aminoaciddependentcmycexpressionisessentialfornkcellmetabolicandfunctionalresponsesinmice
AT angusilamond aminoaciddependentcmycexpressionisessentialfornkcellmetabolicandfunctionalresponsesinmice
AT clairmgardiner aminoaciddependentcmycexpressionisessentialfornkcellmetabolicandfunctionalresponsesinmice
AT katjadettmer aminoaciddependentcmycexpressionisessentialfornkcellmetabolicandfunctionalresponsesinmice
AT doreenacantrell aminoaciddependentcmycexpressionisessentialfornkcellmetabolicandfunctionalresponsesinmice
AT lindavsinclair aminoaciddependentcmycexpressionisessentialfornkcellmetabolicandfunctionalresponsesinmice
AT davidkfinlay aminoaciddependentcmycexpressionisessentialfornkcellmetabolicandfunctionalresponsesinmice
_version_ 1718386834523815936

Ejemplares similares