TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion

ERBB2 overexpression in human breast cancer leads to invasion and metastasis. Here the authors report that ERBB2 induces indirect phosphorylation of TOM1L1 that promotes trafficking of the metalloprotease MT1-MMP to invadopodia, which leads to tumour cell invasion.

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Autores principales:	Clément Chevalier, Guillaume Collin, Simon Descamps, Heiani Touaitahuata, Valérie Simon, Nicolas Reymond, Laurent Fernandez, Pierre-Emmanuel Milhiet, Virginie Georget, Serge Urbach, Laurence Lasorsa, Béatrice Orsetti, Florence Boissière-Michot, Evelyne Lopez-Crapez, Charles Theillet, Serge Roche, Christine Benistant
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/428262dc08104141b0e2cd95b257a423
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spelling	oai:doaj.org-article:428262dc08104141b0e2cd95b257a4232021-12-02T15:35:44ZTOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion10.1038/ncomms107652041-1723https://doaj.org/article/428262dc08104141b0e2cd95b257a4232016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10765https://doaj.org/toc/2041-1723ERBB2 overexpression in human breast cancer leads to invasion and metastasis. Here the authors report that ERBB2 induces indirect phosphorylation of TOM1L1 that promotes trafficking of the metalloprotease MT1-MMP to invadopodia, which leads to tumour cell invasion.Clément ChevalierGuillaume CollinSimon DescampsHeiani TouaitahuataValérie SimonNicolas ReymondLaurent FernandezPierre-Emmanuel MilhietVirginie GeorgetSerge UrbachLaurence LasorsaBéatrice OrsettiFlorence Boissière-MichotEvelyne Lopez-CrapezCharles TheilletSerge RocheChristine BenistantNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Clément Chevalier Guillaume Collin Simon Descamps Heiani Touaitahuata Valérie Simon Nicolas Reymond Laurent Fernandez Pierre-Emmanuel Milhiet Virginie Georget Serge Urbach Laurence Lasorsa Béatrice Orsetti Florence Boissière-Michot Evelyne Lopez-Crapez Charles Theillet Serge Roche Christine Benistant TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion
description	ERBB2 overexpression in human breast cancer leads to invasion and metastasis. Here the authors report that ERBB2 induces indirect phosphorylation of TOM1L1 that promotes trafficking of the metalloprotease MT1-MMP to invadopodia, which leads to tumour cell invasion.
format	article
author	Clément Chevalier Guillaume Collin Simon Descamps Heiani Touaitahuata Valérie Simon Nicolas Reymond Laurent Fernandez Pierre-Emmanuel Milhiet Virginie Georget Serge Urbach Laurence Lasorsa Béatrice Orsetti Florence Boissière-Michot Evelyne Lopez-Crapez Charles Theillet Serge Roche Christine Benistant
author_facet	Clément Chevalier Guillaume Collin Simon Descamps Heiani Touaitahuata Valérie Simon Nicolas Reymond Laurent Fernandez Pierre-Emmanuel Milhiet Virginie Georget Serge Urbach Laurence Lasorsa Béatrice Orsetti Florence Boissière-Michot Evelyne Lopez-Crapez Charles Theillet Serge Roche Christine Benistant
author_sort	Clément Chevalier
title	TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion
title_short	TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion
title_full	TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion
title_fullStr	TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion
title_full_unstemmed	TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion
title_sort	tom1l1 drives membrane delivery of mt1-mmp to promote erbb2-induced breast cancer cell invasion
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/428262dc08104141b0e2cd95b257a423
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TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion

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