Research Advances on the Interactions between Rabies Virus Structural Proteins and Host Target Cells: Accrued Knowledge from the Application of Reverse Genetics Systems

Rabies is a lethal zoonotic disease caused by <i>lyssaviruses</i>, such as rabies virus (RABV), that results in nearly 100% mortality once clinical symptoms appear. There are no curable drugs available yet. RABV contains five structural proteins that play an important role in viral repli...

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Autores principales:	Juanbin Yin, Xiangwei Wang, Ruoqing Mao, Zhixiong Zhang, Xin Gao, Yingying Luo, Yuefeng Sun, Xiangping Yin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	rabies virus structural proteins pathogenesis reverse genetics systems attenuated vaccine strains Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/4282b4dd018d4ea69b9fa8461c42e0ad
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spelling	oai:doaj.org-article:4282b4dd018d4ea69b9fa8461c42e0ad2021-11-25T19:14:12ZResearch Advances on the Interactions between Rabies Virus Structural Proteins and Host Target Cells: Accrued Knowledge from the Application of Reverse Genetics Systems10.3390/v131122881999-4915https://doaj.org/article/4282b4dd018d4ea69b9fa8461c42e0ad2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2288https://doaj.org/toc/1999-4915Rabies is a lethal zoonotic disease caused by <i>lyssaviruses</i>, such as rabies virus (RABV), that results in nearly 100% mortality once clinical symptoms appear. There are no curable drugs available yet. RABV contains five structural proteins that play an important role in viral replication, transcription, infection, and immune escape mechanisms. In the past decade, progress has been made in research on the pathogenicity of RABV, which plays an important role in the creation of new recombinant RABV vaccines by reverse genetic manipulation. Here, we review the latest advances on the interaction between RABV proteins in the infected host and the applied development of rabies vaccines by using a fully operational RABV reverse genetics system. This article provides a background for more in-depth research on the pathogenic mechanism of RABV and the development of therapeutic drugs and new biologics.Juanbin YinXiangwei WangRuoqing MaoZhixiong ZhangXin GaoYingying LuoYuefeng SunXiangping YinMDPI AGarticlerabies virusstructural proteinspathogenesisreverse genetics systemsattenuated vaccine strainsMicrobiologyQR1-502ENViruses, Vol 13, Iss 2288, p 2288 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	rabies virus structural proteins pathogenesis reverse genetics systems attenuated vaccine strains Microbiology QR1-502
spellingShingle	rabies virus structural proteins pathogenesis reverse genetics systems attenuated vaccine strains Microbiology QR1-502 Juanbin Yin Xiangwei Wang Ruoqing Mao Zhixiong Zhang Xin Gao Yingying Luo Yuefeng Sun Xiangping Yin Research Advances on the Interactions between Rabies Virus Structural Proteins and Host Target Cells: Accrued Knowledge from the Application of Reverse Genetics Systems
description	Rabies is a lethal zoonotic disease caused by <i>lyssaviruses</i>, such as rabies virus (RABV), that results in nearly 100% mortality once clinical symptoms appear. There are no curable drugs available yet. RABV contains five structural proteins that play an important role in viral replication, transcription, infection, and immune escape mechanisms. In the past decade, progress has been made in research on the pathogenicity of RABV, which plays an important role in the creation of new recombinant RABV vaccines by reverse genetic manipulation. Here, we review the latest advances on the interaction between RABV proteins in the infected host and the applied development of rabies vaccines by using a fully operational RABV reverse genetics system. This article provides a background for more in-depth research on the pathogenic mechanism of RABV and the development of therapeutic drugs and new biologics.
format	article
author	Juanbin Yin Xiangwei Wang Ruoqing Mao Zhixiong Zhang Xin Gao Yingying Luo Yuefeng Sun Xiangping Yin
author_facet	Juanbin Yin Xiangwei Wang Ruoqing Mao Zhixiong Zhang Xin Gao Yingying Luo Yuefeng Sun Xiangping Yin
author_sort	Juanbin Yin
title	Research Advances on the Interactions between Rabies Virus Structural Proteins and Host Target Cells: Accrued Knowledge from the Application of Reverse Genetics Systems
title_short	Research Advances on the Interactions between Rabies Virus Structural Proteins and Host Target Cells: Accrued Knowledge from the Application of Reverse Genetics Systems
title_full	Research Advances on the Interactions between Rabies Virus Structural Proteins and Host Target Cells: Accrued Knowledge from the Application of Reverse Genetics Systems
title_fullStr	Research Advances on the Interactions between Rabies Virus Structural Proteins and Host Target Cells: Accrued Knowledge from the Application of Reverse Genetics Systems
title_full_unstemmed	Research Advances on the Interactions between Rabies Virus Structural Proteins and Host Target Cells: Accrued Knowledge from the Application of Reverse Genetics Systems
title_sort	research advances on the interactions between rabies virus structural proteins and host target cells: accrued knowledge from the application of reverse genetics systems
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4282b4dd018d4ea69b9fa8461c42e0ad
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Research Advances on the Interactions between Rabies Virus Structural Proteins and Host Target Cells: Accrued Knowledge from the Application of Reverse Genetics Systems

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