CCR5 and Biological Complexity: The Need for Data Integration and Educational Materials to Address Genetic/Biological Reductionism at the Interface of Ethical, Legal, and Social Implications

In the age of genomics, public understanding of complex scientific knowledge is critical. To combat reductionistic views, it is necessary to generate and organize educational material and data that keep pace with advances in genomics. The view that CCR5 is solely the receptor for HIV gave rise to de...

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Autores principales:	Jacob Bauss, Michele Morris, Rama Shankar, Rosemary Olivero, Leah N. Buck, Cynthia L. Stenger, David Hinds, Joshua Mills, Alexandra Eby, Joseph W. Zagorski, Caitlin Smith, Sara Cline, Nicholas L. Hartog, Bin Chen, John Huss, Joseph A. Carcillo, Surender Rajasekaran, Caleb P. Bupp, Jeremy W. Prokop
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	CCR5 viral infections expression analysis evolutionary profiling molecular dynamic simulations microglia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/42832c61612446059f5abf813b814e18
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spelling	oai:doaj.org-article:42832c61612446059f5abf813b814e182021-12-02T09:57:29ZCCR5 and Biological Complexity: The Need for Data Integration and Educational Materials to Address Genetic/Biological Reductionism at the Interface of Ethical, Legal, and Social Implications1664-322410.3389/fimmu.2021.790041https://doaj.org/article/42832c61612446059f5abf813b814e182021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.790041/fullhttps://doaj.org/toc/1664-3224In the age of genomics, public understanding of complex scientific knowledge is critical. To combat reductionistic views, it is necessary to generate and organize educational material and data that keep pace with advances in genomics. The view that CCR5 is solely the receptor for HIV gave rise to demand to remove the gene in patients to create host HIV resistance, underestimating the broader roles and complex genetic inheritance of CCR5. A program aimed at providing research projects to undergraduates, known as CODE, has been expanded to build educational material for genes such as CCR5 in a rapid approach, exposing students and trainees to large bioinformatics databases and previous experiments for broader data to challenge commitment to biological reductionism. Our students organize expression databases, query environmental responses, assess genetic factors, generate protein models/dynamics, and profile evolutionary insights into a protein such as CCR5. The knowledgebase generated in the initiative opens the door for public educational information and tools (molecular videos, 3D printed models, and handouts), classroom materials, and strategy for future genetic ideas that can be distributed in formal, semiformal, and informal educational environments. This work highlights that many factors are missing from the reductionist view of CCR5, including the role of missense variants or expression of CCR5 with neurological phenotypes and the role of CCR5 and the delta32 variant in complex critical care patients with sepsis. When connected to genomic stories in the news, these tools offer critically needed Ethical, Legal, and Social Implication (ELSI) education to combat biological reductionism.Jacob BaussMichele MorrisRama ShankarRosemary OliveroRosemary OliveroLeah N. BuckLeah N. BuckCynthia L. StengerDavid HindsDavid HindsJoshua MillsAlexandra EbyJoseph W. ZagorskiCaitlin SmithSara ClineNicholas L. HartogNicholas L. HartogBin ChenBin ChenJohn HussJoseph A. CarcilloSurender RajasekaranSurender RajasekaranSurender RajasekaranCaleb P. BuppCaleb P. BuppJeremy W. ProkopJeremy W. ProkopFrontiers Media S.A.articleCCR5viral infectionsexpression analysisevolutionary profilingmolecular dynamic simulationsmicrogliaImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CCR5 viral infections expression analysis evolutionary profiling molecular dynamic simulations microglia Immunologic diseases. Allergy RC581-607
spellingShingle	CCR5 viral infections expression analysis evolutionary profiling molecular dynamic simulations microglia Immunologic diseases. Allergy RC581-607 Jacob Bauss Michele Morris Rama Shankar Rosemary Olivero Rosemary Olivero Leah N. Buck Leah N. Buck Cynthia L. Stenger David Hinds David Hinds Joshua Mills Alexandra Eby Joseph W. Zagorski Caitlin Smith Sara Cline Nicholas L. Hartog Nicholas L. Hartog Bin Chen Bin Chen John Huss Joseph A. Carcillo Surender Rajasekaran Surender Rajasekaran Surender Rajasekaran Caleb P. Bupp Caleb P. Bupp Jeremy W. Prokop Jeremy W. Prokop CCR5 and Biological Complexity: The Need for Data Integration and Educational Materials to Address Genetic/Biological Reductionism at the Interface of Ethical, Legal, and Social Implications
description	In the age of genomics, public understanding of complex scientific knowledge is critical. To combat reductionistic views, it is necessary to generate and organize educational material and data that keep pace with advances in genomics. The view that CCR5 is solely the receptor for HIV gave rise to demand to remove the gene in patients to create host HIV resistance, underestimating the broader roles and complex genetic inheritance of CCR5. A program aimed at providing research projects to undergraduates, known as CODE, has been expanded to build educational material for genes such as CCR5 in a rapid approach, exposing students and trainees to large bioinformatics databases and previous experiments for broader data to challenge commitment to biological reductionism. Our students organize expression databases, query environmental responses, assess genetic factors, generate protein models/dynamics, and profile evolutionary insights into a protein such as CCR5. The knowledgebase generated in the initiative opens the door for public educational information and tools (molecular videos, 3D printed models, and handouts), classroom materials, and strategy for future genetic ideas that can be distributed in formal, semiformal, and informal educational environments. This work highlights that many factors are missing from the reductionist view of CCR5, including the role of missense variants or expression of CCR5 with neurological phenotypes and the role of CCR5 and the delta32 variant in complex critical care patients with sepsis. When connected to genomic stories in the news, these tools offer critically needed Ethical, Legal, and Social Implication (ELSI) education to combat biological reductionism.
format	article
author	Jacob Bauss Michele Morris Rama Shankar Rosemary Olivero Rosemary Olivero Leah N. Buck Leah N. Buck Cynthia L. Stenger David Hinds David Hinds Joshua Mills Alexandra Eby Joseph W. Zagorski Caitlin Smith Sara Cline Nicholas L. Hartog Nicholas L. Hartog Bin Chen Bin Chen John Huss Joseph A. Carcillo Surender Rajasekaran Surender Rajasekaran Surender Rajasekaran Caleb P. Bupp Caleb P. Bupp Jeremy W. Prokop Jeremy W. Prokop
author_facet	Jacob Bauss Michele Morris Rama Shankar Rosemary Olivero Rosemary Olivero Leah N. Buck Leah N. Buck Cynthia L. Stenger David Hinds David Hinds Joshua Mills Alexandra Eby Joseph W. Zagorski Caitlin Smith Sara Cline Nicholas L. Hartog Nicholas L. Hartog Bin Chen Bin Chen John Huss Joseph A. Carcillo Surender Rajasekaran Surender Rajasekaran Surender Rajasekaran Caleb P. Bupp Caleb P. Bupp Jeremy W. Prokop Jeremy W. Prokop
author_sort	Jacob Bauss
title	CCR5 and Biological Complexity: The Need for Data Integration and Educational Materials to Address Genetic/Biological Reductionism at the Interface of Ethical, Legal, and Social Implications
title_short	CCR5 and Biological Complexity: The Need for Data Integration and Educational Materials to Address Genetic/Biological Reductionism at the Interface of Ethical, Legal, and Social Implications
title_full	CCR5 and Biological Complexity: The Need for Data Integration and Educational Materials to Address Genetic/Biological Reductionism at the Interface of Ethical, Legal, and Social Implications
title_fullStr	CCR5 and Biological Complexity: The Need for Data Integration and Educational Materials to Address Genetic/Biological Reductionism at the Interface of Ethical, Legal, and Social Implications
title_full_unstemmed	CCR5 and Biological Complexity: The Need for Data Integration and Educational Materials to Address Genetic/Biological Reductionism at the Interface of Ethical, Legal, and Social Implications
title_sort	ccr5 and biological complexity: the need for data integration and educational materials to address genetic/biological reductionism at the interface of ethical, legal, and social implications
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/42832c61612446059f5abf813b814e18
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CCR5 and Biological Complexity: The Need for Data Integration and Educational Materials to Address Genetic/Biological Reductionism at the Interface of Ethical, Legal, and Social Implications

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