Joint Hypermobility in Paediatric Acute-Onset Neuropsychiatric Syndrome—A Preliminary Case-Control Study

Background: Individuals with generalised joint hypermobility (GJH, present in 10–20% of the general population) are at increased risk of being diagnosed with a range of psychiatric and rheumatological conditions. It is unknown whether Paediatric acute-onset neuropsychiatric syndrome (PANS), characte...

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Autores principales:	Susanne Bejerot, Ulrika Hylén, Martin Glans, Eva Hesselmark, Mats B. Humble
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	postural orthostatic tachycardia syndrome paediatric acute-onset neuropsychiatric syndrome psychiatry comorbidity joint hypermobility PNISSI Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/42849b9cd5bf4a259d5c8d547f5631e2
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spelling	oai:doaj.org-article:42849b9cd5bf4a259d5c8d547f5631e22021-12-03T06:03:33ZJoint Hypermobility in Paediatric Acute-Onset Neuropsychiatric Syndrome—A Preliminary Case-Control Study1664-064010.3389/fpsyt.2021.797165https://doaj.org/article/42849b9cd5bf4a259d5c8d547f5631e22021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.797165/fullhttps://doaj.org/toc/1664-0640Background: Individuals with generalised joint hypermobility (GJH, present in 10–20% of the general population) are at increased risk of being diagnosed with a range of psychiatric and rheumatological conditions. It is unknown whether Paediatric acute-onset neuropsychiatric syndrome (PANS), characterised by childhood onset obsessive-compulsive disorder or restricted eating and typically associated with several comorbid neuropsychiatric symptoms, is associated with GJH. It is also unknown whether extensive psychiatric comorbidity is associated with GJH.Method: This is a case-control study including 105 participants. We compared three groups: Individuals with PANS, individuals with other mental disorders and healthy controls. Joint mobility was assessed with the Beighton scoring system, psychiatric comorbidity with the M.I.N.I. or MINI-KID interview and symptoms of PANS with the PsychoNeuroInflammatory related Signs and Symptoms Inventory (PNISSI).Results: Hypermobility was similar across groups, and high rates of psychiatric comorbidity was not associated with higher Beighton scores.Conclusion: Although GJH is associated with several psychiatric conditions, such as ADHD and anxiety, this does not seem to be the case for PANS according to this preliminary study.Susanne BejerotSusanne BejerotUlrika HylénUlrika HylénMartin GlansEva HesselmarkEva HesselmarkMats B. HumbleFrontiers Media S.A.articlepostural orthostatic tachycardia syndromepaediatric acute-onset neuropsychiatric syndromepsychiatrycomorbidityjoint hypermobilityPNISSIPsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	postural orthostatic tachycardia syndrome paediatric acute-onset neuropsychiatric syndrome psychiatry comorbidity joint hypermobility PNISSI Psychiatry RC435-571
spellingShingle	postural orthostatic tachycardia syndrome paediatric acute-onset neuropsychiatric syndrome psychiatry comorbidity joint hypermobility PNISSI Psychiatry RC435-571 Susanne Bejerot Susanne Bejerot Ulrika Hylén Ulrika Hylén Martin Glans Eva Hesselmark Eva Hesselmark Mats B. Humble Joint Hypermobility in Paediatric Acute-Onset Neuropsychiatric Syndrome—A Preliminary Case-Control Study
description	Background: Individuals with generalised joint hypermobility (GJH, present in 10–20% of the general population) are at increased risk of being diagnosed with a range of psychiatric and rheumatological conditions. It is unknown whether Paediatric acute-onset neuropsychiatric syndrome (PANS), characterised by childhood onset obsessive-compulsive disorder or restricted eating and typically associated with several comorbid neuropsychiatric symptoms, is associated with GJH. It is also unknown whether extensive psychiatric comorbidity is associated with GJH.Method: This is a case-control study including 105 participants. We compared three groups: Individuals with PANS, individuals with other mental disorders and healthy controls. Joint mobility was assessed with the Beighton scoring system, psychiatric comorbidity with the M.I.N.I. or MINI-KID interview and symptoms of PANS with the PsychoNeuroInflammatory related Signs and Symptoms Inventory (PNISSI).Results: Hypermobility was similar across groups, and high rates of psychiatric comorbidity was not associated with higher Beighton scores.Conclusion: Although GJH is associated with several psychiatric conditions, such as ADHD and anxiety, this does not seem to be the case for PANS according to this preliminary study.
format	article
author	Susanne Bejerot Susanne Bejerot Ulrika Hylén Ulrika Hylén Martin Glans Eva Hesselmark Eva Hesselmark Mats B. Humble
author_facet	Susanne Bejerot Susanne Bejerot Ulrika Hylén Ulrika Hylén Martin Glans Eva Hesselmark Eva Hesselmark Mats B. Humble
author_sort	Susanne Bejerot
title	Joint Hypermobility in Paediatric Acute-Onset Neuropsychiatric Syndrome—A Preliminary Case-Control Study
title_short	Joint Hypermobility in Paediatric Acute-Onset Neuropsychiatric Syndrome—A Preliminary Case-Control Study
title_full	Joint Hypermobility in Paediatric Acute-Onset Neuropsychiatric Syndrome—A Preliminary Case-Control Study
title_fullStr	Joint Hypermobility in Paediatric Acute-Onset Neuropsychiatric Syndrome—A Preliminary Case-Control Study
title_full_unstemmed	Joint Hypermobility in Paediatric Acute-Onset Neuropsychiatric Syndrome—A Preliminary Case-Control Study
title_sort	joint hypermobility in paediatric acute-onset neuropsychiatric syndrome—a preliminary case-control study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/42849b9cd5bf4a259d5c8d547f5631e2
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Joint Hypermobility in Paediatric Acute-Onset Neuropsychiatric Syndrome—A Preliminary Case-Control Study

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