Hexafluoropropylene oxide dimer acid (GenX) exposure induces apoptosis in HepG2 cells

Hexafluoropropylene oxide dimer acid, also known as GenX, is a poly- and perfluoroalkyl substance (PFAS). PFASs are nonvolatile synthetic substances that can be readily disseminated into the environment during processing and use, making them easy to implement in the soil, drinking water, and air. Co...

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Autores principales:	Hee Joon Yoo, Min Cheol Pyo, Yoonjin Park, Bo Yong Kim, Kwang-Won Lee
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Poly- and perfluoroalkyl substance Hexafluoropropylene oxide dimer acid Oxidative stress Apoptosis Liver cells Science (General) Q1-390 Social sciences (General) H1-99
Acceso en línea:	https://doaj.org/article/42880c08c6894e9b8c459a40d9444d98
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spelling	oai:doaj.org-article:42880c08c6894e9b8c459a40d9444d982021-12-02T05:02:22ZHexafluoropropylene oxide dimer acid (GenX) exposure induces apoptosis in HepG2 cells2405-844010.1016/j.heliyon.2021.e08272https://doaj.org/article/42880c08c6894e9b8c459a40d9444d982021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405844021023756https://doaj.org/toc/2405-8440Hexafluoropropylene oxide dimer acid, also known as GenX, is a poly- and perfluoroalkyl substance (PFAS). PFASs are nonvolatile synthetic substances that can be readily disseminated into the environment during processing and use, making them easy to implement in the soil, drinking water, and air. Compared to other PFASs, GenX has a comparatively short carbon chain length and is expected to have a lower tendency to accumulate in humans; therefore, GenX has recently been used as a substitute to other PFASs. However, the mechanisms underlying GenX action and intoxication in humans remains unclear. In this study, the apoptotic capacity of GenX in human liver cells was investigated. When representative human-derived liver cells (HepG2 cells) were treated with GenX for 12 h, cell viability was reduced, and apoptosis was greatly increased. In addition, GenX increased the generation of intracellular reactive oxygen species (ROS), indicating the induction of oxidative stress in a dose-dependent manner. GenX treatment increased the expression of major apoptosis-related genes relative to the untreated control group. This research indicates that GenX causes apoptosis through ROS mediation in HepG2 cells, which may expand our knowledge of the molecular and toxicological mechanisms of GenX.Hee Joon YooMin Cheol PyoYoonjin ParkBo Yong KimKwang-Won LeeElsevierarticlePoly- and perfluoroalkyl substanceHexafluoropropylene oxide dimer acidOxidative stressApoptosisLiver cellsScience (General)Q1-390Social sciences (General)H1-99ENHeliyon, Vol 7, Iss 11, Pp e08272- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Poly- and perfluoroalkyl substance Hexafluoropropylene oxide dimer acid Oxidative stress Apoptosis Liver cells Science (General) Q1-390 Social sciences (General) H1-99
spellingShingle	Poly- and perfluoroalkyl substance Hexafluoropropylene oxide dimer acid Oxidative stress Apoptosis Liver cells Science (General) Q1-390 Social sciences (General) H1-99 Hee Joon Yoo Min Cheol Pyo Yoonjin Park Bo Yong Kim Kwang-Won Lee Hexafluoropropylene oxide dimer acid (GenX) exposure induces apoptosis in HepG2 cells
description	Hexafluoropropylene oxide dimer acid, also known as GenX, is a poly- and perfluoroalkyl substance (PFAS). PFASs are nonvolatile synthetic substances that can be readily disseminated into the environment during processing and use, making them easy to implement in the soil, drinking water, and air. Compared to other PFASs, GenX has a comparatively short carbon chain length and is expected to have a lower tendency to accumulate in humans; therefore, GenX has recently been used as a substitute to other PFASs. However, the mechanisms underlying GenX action and intoxication in humans remains unclear. In this study, the apoptotic capacity of GenX in human liver cells was investigated. When representative human-derived liver cells (HepG2 cells) were treated with GenX for 12 h, cell viability was reduced, and apoptosis was greatly increased. In addition, GenX increased the generation of intracellular reactive oxygen species (ROS), indicating the induction of oxidative stress in a dose-dependent manner. GenX treatment increased the expression of major apoptosis-related genes relative to the untreated control group. This research indicates that GenX causes apoptosis through ROS mediation in HepG2 cells, which may expand our knowledge of the molecular and toxicological mechanisms of GenX.
format	article
author	Hee Joon Yoo Min Cheol Pyo Yoonjin Park Bo Yong Kim Kwang-Won Lee
author_facet	Hee Joon Yoo Min Cheol Pyo Yoonjin Park Bo Yong Kim Kwang-Won Lee
author_sort	Hee Joon Yoo
title	Hexafluoropropylene oxide dimer acid (GenX) exposure induces apoptosis in HepG2 cells
title_short	Hexafluoropropylene oxide dimer acid (GenX) exposure induces apoptosis in HepG2 cells
title_full	Hexafluoropropylene oxide dimer acid (GenX) exposure induces apoptosis in HepG2 cells
title_fullStr	Hexafluoropropylene oxide dimer acid (GenX) exposure induces apoptosis in HepG2 cells
title_full_unstemmed	Hexafluoropropylene oxide dimer acid (GenX) exposure induces apoptosis in HepG2 cells
title_sort	hexafluoropropylene oxide dimer acid (genx) exposure induces apoptosis in hepg2 cells
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/42880c08c6894e9b8c459a40d9444d98
work_keys_str_mv	AT heejoonyoo hexafluoropropyleneoxidedimeracidgenxexposureinducesapoptosisinhepg2cells AT mincheolpyo hexafluoropropyleneoxidedimeracidgenxexposureinducesapoptosisinhepg2cells AT yoonjinpark hexafluoropropyleneoxidedimeracidgenxexposureinducesapoptosisinhepg2cells AT boyongkim hexafluoropropyleneoxidedimeracidgenxexposureinducesapoptosisinhepg2cells AT kwangwonlee hexafluoropropyleneoxidedimeracidgenxexposureinducesapoptosisinhepg2cells
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Hexafluoropropylene oxide dimer acid (GenX) exposure induces apoptosis in HepG2 cells

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