Towards Translational Epidemiology: Next-Generation Sequencing and Phylogeography as Epidemiological Mainstays

ABSTRACT Next-generation sequencing, coupled with the development of user-friendly software, has achieved a level of accessibility that is revolutionizing the way we approach epidemiological investigations. We can sequence pathogen genomes and conduct phylogenetic analyses to assess transmission, id...

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Autor principal:	Crystal M. Hepp
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	public health translational epidemiology vector-borne diseases zoonotic disease Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/428bdd7bff2c485db269912db551088d
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spelling	oai:doaj.org-article:428bdd7bff2c485db269912db551088d2021-12-02T19:46:18ZTowards Translational Epidemiology: Next-Generation Sequencing and Phylogeography as Epidemiological Mainstays10.1128/mSystems.00119-192379-5077https://doaj.org/article/428bdd7bff2c485db269912db551088d2019-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00119-19https://doaj.org/toc/2379-5077ABSTRACT Next-generation sequencing, coupled with the development of user-friendly software, has achieved a level of accessibility that is revolutionizing the way we approach epidemiological investigations. We can sequence pathogen genomes and conduct phylogenetic analyses to assess transmission, identify from which country or city a pathogen originated, or which contaminated potluck item resulted in widespread foodborne illness. However, until recently, these types of studies have been rarities, limited to specific investigations usually conducted over the short term. Given the feasibility and realized public health benefits of ascertaining pathogen relationships, federal, state, and county agencies are building their sequencing capacities, either through acquisition of equipment or collaborative activities. In this perspective, I detail research projects that our group collaborates on with county and state public health agencies, where the objective is to identify pathogen source locations with the longer-term goal of implementing proactive interventions.Crystal M. HeppAmerican Society for Microbiologyarticlepublic healthtranslational epidemiologyvector-borne diseaseszoonotic diseaseMicrobiologyQR1-502ENmSystems, Vol 4, Iss 3 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	public health translational epidemiology vector-borne diseases zoonotic disease Microbiology QR1-502
spellingShingle	public health translational epidemiology vector-borne diseases zoonotic disease Microbiology QR1-502 Crystal M. Hepp Towards Translational Epidemiology: Next-Generation Sequencing and Phylogeography as Epidemiological Mainstays
description	ABSTRACT Next-generation sequencing, coupled with the development of user-friendly software, has achieved a level of accessibility that is revolutionizing the way we approach epidemiological investigations. We can sequence pathogen genomes and conduct phylogenetic analyses to assess transmission, identify from which country or city a pathogen originated, or which contaminated potluck item resulted in widespread foodborne illness. However, until recently, these types of studies have been rarities, limited to specific investigations usually conducted over the short term. Given the feasibility and realized public health benefits of ascertaining pathogen relationships, federal, state, and county agencies are building their sequencing capacities, either through acquisition of equipment or collaborative activities. In this perspective, I detail research projects that our group collaborates on with county and state public health agencies, where the objective is to identify pathogen source locations with the longer-term goal of implementing proactive interventions.
format	article
author	Crystal M. Hepp
author_facet	Crystal M. Hepp
author_sort	Crystal M. Hepp
title	Towards Translational Epidemiology: Next-Generation Sequencing and Phylogeography as Epidemiological Mainstays
title_short	Towards Translational Epidemiology: Next-Generation Sequencing and Phylogeography as Epidemiological Mainstays
title_full	Towards Translational Epidemiology: Next-Generation Sequencing and Phylogeography as Epidemiological Mainstays
title_fullStr	Towards Translational Epidemiology: Next-Generation Sequencing and Phylogeography as Epidemiological Mainstays
title_full_unstemmed	Towards Translational Epidemiology: Next-Generation Sequencing and Phylogeography as Epidemiological Mainstays
title_sort	towards translational epidemiology: next-generation sequencing and phylogeography as epidemiological mainstays
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/428bdd7bff2c485db269912db551088d
work_keys_str_mv	AT crystalmhepp towardstranslationalepidemiologynextgenerationsequencingandphylogeographyasepidemiologicalmainstays
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Towards Translational Epidemiology: Next-Generation Sequencing and Phylogeography as Epidemiological Mainstays

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