SOME IMMUNOLOGICAL INDICATORS IN CERVICAL PATHOLOGY ASSOCIATED WITH PAPILLOMAVIRUS INFECTION

Abstract. To study immunological indices and functional activity of neutrophils in women with human papillomavirus infection (HPV), as well as their dependence on severity of cervical morphological alterations, we examined sixty-seven female patients in their reproductive age. It was found that, reg...

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Auteurs principaux:	A. A. Savchenko, V. B. Tskhay, D. Yu. Kruglova, A. G. Borisov
Format:	article
Langue:	RU
Publié:	SPb RAACI 2014
Sujets:	lymphocytes neutrophilic granulocytes papillomavirus infection sub-clinical forms leukoplakia dysplasia Immunologic diseases. Allergy RC581-607
Accès en ligne:	https://doaj.org/article/428d6b6c1f424ad5bcf01095a6b40f03
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spelling	oai:doaj.org-article:428d6b6c1f424ad5bcf01095a6b40f032021-11-18T08:03:40ZSOME IMMUNOLOGICAL INDICATORS IN CERVICAL PATHOLOGY ASSOCIATED WITH PAPILLOMAVIRUS INFECTION1563-06252313-741X10.15789/1563-0625-2012-3-207-212https://doaj.org/article/428d6b6c1f424ad5bcf01095a6b40f032014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/348https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. To study immunological indices and functional activity of neutrophils in women with human papillomavirus infection (HPV), as well as their dependence on severity of cervical morphological alterations, we examined sixty-seven female patients in their reproductive age. It was found that, regardless of severity of pathological changes in uterine cervix, the women with HPV infection show decreased numbers of NK cells and CD4+ lymphocytes in peripheral blood, along with increased contents of gd T cells. In cases of combined sub-clinical infection with leukoplakia and endocervicosis, more severe disorders of cellular immunity were detectable than in CIN I and CIN II. It is assumed, that initial neoplastic processes with HPV background are accompanied by a more pronounced immune response. Meanwhile, functional activity of neutrophilic granulocytes varies in an inverse manner, being, generally, increased in common HPV infection, followed by most significant changes in CIN I and CIN II.A. A. SavchenkoV. B. TskhayD. Yu. KruglovaA. G. BorisovSPb RAACIarticlelymphocytesneutrophilic granulocytespapillomavirus infectionsub-clinical formsleukoplakiadysplasiaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 3, Pp 207-212 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	lymphocytes neutrophilic granulocytes papillomavirus infection sub-clinical forms leukoplakia dysplasia Immunologic diseases. Allergy RC581-607
spellingShingle	lymphocytes neutrophilic granulocytes papillomavirus infection sub-clinical forms leukoplakia dysplasia Immunologic diseases. Allergy RC581-607 A. A. Savchenko V. B. Tskhay D. Yu. Kruglova A. G. Borisov SOME IMMUNOLOGICAL INDICATORS IN CERVICAL PATHOLOGY ASSOCIATED WITH PAPILLOMAVIRUS INFECTION
description	Abstract. To study immunological indices and functional activity of neutrophils in women with human papillomavirus infection (HPV), as well as their dependence on severity of cervical morphological alterations, we examined sixty-seven female patients in their reproductive age. It was found that, regardless of severity of pathological changes in uterine cervix, the women with HPV infection show decreased numbers of NK cells and CD4+ lymphocytes in peripheral blood, along with increased contents of gd T cells. In cases of combined sub-clinical infection with leukoplakia and endocervicosis, more severe disorders of cellular immunity were detectable than in CIN I and CIN II. It is assumed, that initial neoplastic processes with HPV background are accompanied by a more pronounced immune response. Meanwhile, functional activity of neutrophilic granulocytes varies in an inverse manner, being, generally, increased in common HPV infection, followed by most significant changes in CIN I and CIN II.
format	article
author	A. A. Savchenko V. B. Tskhay D. Yu. Kruglova A. G. Borisov
author_facet	A. A. Savchenko V. B. Tskhay D. Yu. Kruglova A. G. Borisov
author_sort	A. A. Savchenko
title	SOME IMMUNOLOGICAL INDICATORS IN CERVICAL PATHOLOGY ASSOCIATED WITH PAPILLOMAVIRUS INFECTION
title_short	SOME IMMUNOLOGICAL INDICATORS IN CERVICAL PATHOLOGY ASSOCIATED WITH PAPILLOMAVIRUS INFECTION
title_full	SOME IMMUNOLOGICAL INDICATORS IN CERVICAL PATHOLOGY ASSOCIATED WITH PAPILLOMAVIRUS INFECTION
title_fullStr	SOME IMMUNOLOGICAL INDICATORS IN CERVICAL PATHOLOGY ASSOCIATED WITH PAPILLOMAVIRUS INFECTION
title_full_unstemmed	SOME IMMUNOLOGICAL INDICATORS IN CERVICAL PATHOLOGY ASSOCIATED WITH PAPILLOMAVIRUS INFECTION
title_sort	some immunological indicators in cervical pathology associated with papillomavirus infection
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/428d6b6c1f424ad5bcf01095a6b40f03
work_keys_str_mv	AT aasavchenko someimmunologicalindicatorsincervicalpathologyassociatedwithpapillomavirusinfection AT vbtskhay someimmunologicalindicatorsincervicalpathologyassociatedwithpapillomavirusinfection AT dyukruglova someimmunologicalindicatorsincervicalpathologyassociatedwithpapillomavirusinfection AT agborisov someimmunologicalindicatorsincervicalpathologyassociatedwithpapillomavirusinfection
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SOME IMMUNOLOGICAL INDICATORS IN CERVICAL PATHOLOGY ASSOCIATED WITH PAPILLOMAVIRUS INFECTION

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