High-resolution single-cell 3D-models of chromatin ensembles during Drosophila embryogenesis

Balancing high resolution and broad genome coverage in single-cell Hi-C approaches remains challenging. Here, the authors describe a computational method for the reconstruction of a large 3D-ensemble of single-cell chromatin conformations from population Hi-C measurements and apply this model to stu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Qiu Sun, Alan Perez-Rathke, Daniel M. Czajkowsky, Zhifeng Shao, Jie Liang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/428dc5ecd1944d54b2860c136832f5a2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:428dc5ecd1944d54b2860c136832f5a2
record_format	dspace
spelling	oai:doaj.org-article:428dc5ecd1944d54b2860c136832f5a22021-12-02T15:16:22ZHigh-resolution single-cell 3D-models of chromatin ensembles during Drosophila embryogenesis10.1038/s41467-020-20490-92041-1723https://doaj.org/article/428dc5ecd1944d54b2860c136832f5a22021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20490-9https://doaj.org/toc/2041-1723Balancing high resolution and broad genome coverage in single-cell Hi-C approaches remains challenging. Here, the authors describe a computational method for the reconstruction of a large 3D-ensemble of single-cell chromatin conformations from population Hi-C measurements and apply this model to study embryogenesis in D r o s o p h i l a.Qiu SunAlan Perez-RathkeDaniel M. CzajkowskyZhifeng ShaoJie LiangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qiu Sun Alan Perez-Rathke Daniel M. Czajkowsky Zhifeng Shao Jie Liang High-resolution single-cell 3D-models of chromatin ensembles during Drosophila embryogenesis
description	Balancing high resolution and broad genome coverage in single-cell Hi-C approaches remains challenging. Here, the authors describe a computational method for the reconstruction of a large 3D-ensemble of single-cell chromatin conformations from population Hi-C measurements and apply this model to study embryogenesis in D r o s o p h i l a.
format	article
author	Qiu Sun Alan Perez-Rathke Daniel M. Czajkowsky Zhifeng Shao Jie Liang
author_facet	Qiu Sun Alan Perez-Rathke Daniel M. Czajkowsky Zhifeng Shao Jie Liang
author_sort	Qiu Sun
title	High-resolution single-cell 3D-models of chromatin ensembles during Drosophila embryogenesis
title_short	High-resolution single-cell 3D-models of chromatin ensembles during Drosophila embryogenesis
title_full	High-resolution single-cell 3D-models of chromatin ensembles during Drosophila embryogenesis
title_fullStr	High-resolution single-cell 3D-models of chromatin ensembles during Drosophila embryogenesis
title_full_unstemmed	High-resolution single-cell 3D-models of chromatin ensembles during Drosophila embryogenesis
title_sort	high-resolution single-cell 3d-models of chromatin ensembles during drosophila embryogenesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/428dc5ecd1944d54b2860c136832f5a2
work_keys_str_mv	AT qiusun highresolutionsinglecell3dmodelsofchromatinensemblesduringdrosophilaembryogenesis AT alanperezrathke highresolutionsinglecell3dmodelsofchromatinensemblesduringdrosophilaembryogenesis AT danielmczajkowsky highresolutionsinglecell3dmodelsofchromatinensemblesduringdrosophilaembryogenesis AT zhifengshao highresolutionsinglecell3dmodelsofchromatinensemblesduringdrosophilaembryogenesis AT jieliang highresolutionsinglecell3dmodelsofchromatinensemblesduringdrosophilaembryogenesis
_version_	1718387502186758144

High-resolution single-cell 3D-models of chromatin ensembles during Drosophila embryogenesis

Ejemplares similares