High-resolution single-cell 3D-models of chromatin ensembles during Drosophila embryogenesis

High-resolution single-cell 3D-models of chromatin ensembles during Drosophila embryogenesis

Balancing high resolution and broad genome coverage in single-cell Hi-C approaches remains challenging. Here, the authors describe a computational method for the reconstruction of a large 3D-ensemble of single-cell chromatin conformations from population Hi-C measurements and apply this model to stu...

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Autores principales: Qiu Sun, Alan Perez-Rathke, Daniel M. Czajkowsky, Zhifeng Shao, Jie Liang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/428dc5ecd1944d54b2860c136832f5a2
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