Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery

Obesity is a major risk factor for cancer related death. Here, the authors show that visceral adipose-derived factors promote vasculogenesis and metastatic dissemination by activation of STAT3, which inhibits miR-200a and enhances ZEB2 expression, effectively reprogramming colorectal cancer cells in...

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Autores principales:	Simone Di Franco, Paola Bianca, Davide Stefano Sardina, Alice Turdo, Miriam Gaggianesi, Veronica Veschi, Annalisa Nicotra, Laura Rosa Mangiapane, Melania Lo Iacono, Irene Pillitteri, Sander van Hooff, Federica Martorana, Gianmarco Motta, Eliana Gulotta, Vincenzo Luca Lentini, Emanuele Martorana, Micol Eleonora Fiori, Salvatore Vieni, Maria Rita Bongiorno, Giorgio Giannone, Dario Giuffrida, Lorenzo Memeo, Lorenzo Colarossi, Marzia Mare, Paolo Vigneri, Matilde Todaro, Ruggero De Maria, Jan Paul Medema, Giorgio Stassi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4290ce7ba4614241baeb5615eb552e3e
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spelling	oai:doaj.org-article:4290ce7ba4614241baeb5615eb552e3e2021-12-02T17:08:38ZAdipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery10.1038/s41467-021-25333-92041-1723https://doaj.org/article/4290ce7ba4614241baeb5615eb552e3e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25333-9https://doaj.org/toc/2041-1723Obesity is a major risk factor for cancer related death. Here, the authors show that visceral adipose-derived factors promote vasculogenesis and metastatic dissemination by activation of STAT3, which inhibits miR-200a and enhances ZEB2 expression, effectively reprogramming colorectal cancer cells into a highly metastatic phenotype.Simone Di FrancoPaola BiancaDavide Stefano SardinaAlice TurdoMiriam GaggianesiVeronica VeschiAnnalisa NicotraLaura Rosa MangiapaneMelania Lo IaconoIrene PillitteriSander van HooffFederica MartoranaGianmarco MottaEliana GulottaVincenzo Luca LentiniEmanuele MartoranaMicol Eleonora FioriSalvatore VieniMaria Rita BongiornoGiorgio GiannoneDario GiuffridaLorenzo MemeoLorenzo ColarossiMarzia MarePaolo VigneriMatilde TodaroRuggero De MariaJan Paul MedemaGiorgio StassiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simone Di Franco Paola Bianca Davide Stefano Sardina Alice Turdo Miriam Gaggianesi Veronica Veschi Annalisa Nicotra Laura Rosa Mangiapane Melania Lo Iacono Irene Pillitteri Sander van Hooff Federica Martorana Gianmarco Motta Eliana Gulotta Vincenzo Luca Lentini Emanuele Martorana Micol Eleonora Fiori Salvatore Vieni Maria Rita Bongiorno Giorgio Giannone Dario Giuffrida Lorenzo Memeo Lorenzo Colarossi Marzia Mare Paolo Vigneri Matilde Todaro Ruggero De Maria Jan Paul Medema Giorgio Stassi Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery
description	Obesity is a major risk factor for cancer related death. Here, the authors show that visceral adipose-derived factors promote vasculogenesis and metastatic dissemination by activation of STAT3, which inhibits miR-200a and enhances ZEB2 expression, effectively reprogramming colorectal cancer cells into a highly metastatic phenotype.
format	article
author	Simone Di Franco Paola Bianca Davide Stefano Sardina Alice Turdo Miriam Gaggianesi Veronica Veschi Annalisa Nicotra Laura Rosa Mangiapane Melania Lo Iacono Irene Pillitteri Sander van Hooff Federica Martorana Gianmarco Motta Eliana Gulotta Vincenzo Luca Lentini Emanuele Martorana Micol Eleonora Fiori Salvatore Vieni Maria Rita Bongiorno Giorgio Giannone Dario Giuffrida Lorenzo Memeo Lorenzo Colarossi Marzia Mare Paolo Vigneri Matilde Todaro Ruggero De Maria Jan Paul Medema Giorgio Stassi
author_facet	Simone Di Franco Paola Bianca Davide Stefano Sardina Alice Turdo Miriam Gaggianesi Veronica Veschi Annalisa Nicotra Laura Rosa Mangiapane Melania Lo Iacono Irene Pillitteri Sander van Hooff Federica Martorana Gianmarco Motta Eliana Gulotta Vincenzo Luca Lentini Emanuele Martorana Micol Eleonora Fiori Salvatore Vieni Maria Rita Bongiorno Giorgio Giannone Dario Giuffrida Lorenzo Memeo Lorenzo Colarossi Marzia Mare Paolo Vigneri Matilde Todaro Ruggero De Maria Jan Paul Medema Giorgio Stassi
author_sort	Simone Di Franco
title	Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery
title_short	Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery
title_full	Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery
title_fullStr	Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery
title_full_unstemmed	Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery
title_sort	adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4290ce7ba4614241baeb5615eb552e3e
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Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery

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