Interaction between Non-Coding RNAs and Androgen Receptor with an Especial Focus on Prostate Cancer

The androgen receptor (AR) is a member of the nuclear receptor superfamily and has three functional domains, namely the N-terminal, DNA binding, and C-terminal domain. The N-terminal domain harbors potent transactivation functions, whereas the C-terminal domain binds to androgens and antiandrogens u...

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Autores principales:	Mohammad Taheri, Tayyebeh Khoshbakht, Elena Jamali, Julia Kallenbach, Soudeh Ghafouri-Fard, Aria Baniahmad
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	androgen receptor miRNA lncRNA circular RNAs prostate cancer Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4291a0fcb65a4b378fa033456c72936c
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spelling	oai:doaj.org-article:4291a0fcb65a4b378fa033456c72936c2021-11-25T17:12:46ZInteraction between Non-Coding RNAs and Androgen Receptor with an Especial Focus on Prostate Cancer10.3390/cells101131982073-4409https://doaj.org/article/4291a0fcb65a4b378fa033456c72936c2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3198https://doaj.org/toc/2073-4409The androgen receptor (AR) is a member of the nuclear receptor superfamily and has three functional domains, namely the N-terminal, DNA binding, and C-terminal domain. The N-terminal domain harbors potent transactivation functions, whereas the C-terminal domain binds to androgens and antiandrogens used to treat prostate cancer. AR has genomic activity being DNA binding-dependent or through interaction with other DNA-bound transcription factors, as well as a number of non-genomic, non-canonical functions, such as the activation of the ERK, AKT, and MAPK pathways. A bulk of evidence indicates that non-coding RNAs have functional interactions with AR. This type of interaction is implicated in the pathogenesis of human malignancies, particularly prostate cancer. In the current review, we summarize the available data on the role of microRNAs, long non-coding RNAs, and circular RNAs on the expression of AR and modulation of AR signaling, as well as the effects of AR on their expression. Recognition of the complicated interaction between non-coding RNAs and AR has practical importance in the design of novel treatment options, as well as modulation of response to conventional therapeutics.Mohammad TaheriTayyebeh KhoshbakhtElena JamaliJulia KallenbachSoudeh Ghafouri-FardAria BaniahmadMDPI AGarticleandrogen receptormiRNAlncRNAcircular RNAsprostate cancerBiology (General)QH301-705.5ENCells, Vol 10, Iss 3198, p 3198 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	androgen receptor miRNA lncRNA circular RNAs prostate cancer Biology (General) QH301-705.5
spellingShingle	androgen receptor miRNA lncRNA circular RNAs prostate cancer Biology (General) QH301-705.5 Mohammad Taheri Tayyebeh Khoshbakht Elena Jamali Julia Kallenbach Soudeh Ghafouri-Fard Aria Baniahmad Interaction between Non-Coding RNAs and Androgen Receptor with an Especial Focus on Prostate Cancer
description	The androgen receptor (AR) is a member of the nuclear receptor superfamily and has three functional domains, namely the N-terminal, DNA binding, and C-terminal domain. The N-terminal domain harbors potent transactivation functions, whereas the C-terminal domain binds to androgens and antiandrogens used to treat prostate cancer. AR has genomic activity being DNA binding-dependent or through interaction with other DNA-bound transcription factors, as well as a number of non-genomic, non-canonical functions, such as the activation of the ERK, AKT, and MAPK pathways. A bulk of evidence indicates that non-coding RNAs have functional interactions with AR. This type of interaction is implicated in the pathogenesis of human malignancies, particularly prostate cancer. In the current review, we summarize the available data on the role of microRNAs, long non-coding RNAs, and circular RNAs on the expression of AR and modulation of AR signaling, as well as the effects of AR on their expression. Recognition of the complicated interaction between non-coding RNAs and AR has practical importance in the design of novel treatment options, as well as modulation of response to conventional therapeutics.
format	article
author	Mohammad Taheri Tayyebeh Khoshbakht Elena Jamali Julia Kallenbach Soudeh Ghafouri-Fard Aria Baniahmad
author_facet	Mohammad Taheri Tayyebeh Khoshbakht Elena Jamali Julia Kallenbach Soudeh Ghafouri-Fard Aria Baniahmad
author_sort	Mohammad Taheri
title	Interaction between Non-Coding RNAs and Androgen Receptor with an Especial Focus on Prostate Cancer
title_short	Interaction between Non-Coding RNAs and Androgen Receptor with an Especial Focus on Prostate Cancer
title_full	Interaction between Non-Coding RNAs and Androgen Receptor with an Especial Focus on Prostate Cancer
title_fullStr	Interaction between Non-Coding RNAs and Androgen Receptor with an Especial Focus on Prostate Cancer
title_full_unstemmed	Interaction between Non-Coding RNAs and Androgen Receptor with an Especial Focus on Prostate Cancer
title_sort	interaction between non-coding rnas and androgen receptor with an especial focus on prostate cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4291a0fcb65a4b378fa033456c72936c
work_keys_str_mv	AT mohammadtaheri interactionbetweennoncodingrnasandandrogenreceptorwithanespecialfocusonprostatecancer AT tayyebehkhoshbakht interactionbetweennoncodingrnasandandrogenreceptorwithanespecialfocusonprostatecancer AT elenajamali interactionbetweennoncodingrnasandandrogenreceptorwithanespecialfocusonprostatecancer AT juliakallenbach interactionbetweennoncodingrnasandandrogenreceptorwithanespecialfocusonprostatecancer AT soudehghafourifard interactionbetweennoncodingrnasandandrogenreceptorwithanespecialfocusonprostatecancer AT ariabaniahmad interactionbetweennoncodingrnasandandrogenreceptorwithanespecialfocusonprostatecancer
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Interaction between Non-Coding RNAs and Androgen Receptor with an Especial Focus on Prostate Cancer

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