Significance of serum palmitoleic acid levels in inflammatory bowel disease

Abstract Inflammatory bowel diseases (IBDs), including ulcerative colitis (UC) and Crohn’s disease (CD), are chronic intestinal diseases of unknown etiology that present with variable disease extents and outcomes. The use of biomarkers for the diagnosis and management of IBDs is considered beneficia...

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Autores principales:	Yuko Akazawa, Tomohito Morisaki, Hiroko Fukuda, Kiyuu Norimatsu, Junya Shiota, Keiichi Hashiguchi, Maiko Tabuchi, Moto Kitayama, Kayoko Matsushima, Naoyuki Yamaguchi, Hisayoshi Kondo, Fumihiko Fujita, Hiroaki Takeshita, Kazuhiko Nakao, Fuminao Takeshima
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/42922ebd13cf49c5b22a376a5d63310e
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spelling	oai:doaj.org-article:42922ebd13cf49c5b22a376a5d63310e2021-12-02T16:43:42ZSignificance of serum palmitoleic acid levels in inflammatory bowel disease10.1038/s41598-021-95923-62045-2322https://doaj.org/article/42922ebd13cf49c5b22a376a5d63310e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95923-6https://doaj.org/toc/2045-2322Abstract Inflammatory bowel diseases (IBDs), including ulcerative colitis (UC) and Crohn’s disease (CD), are chronic intestinal diseases of unknown etiology that present with variable disease extents and outcomes. The use of biomarkers for the diagnosis and management of IBDs is considered beneficial. Palmitoleic acid (PO) is an adipose tissue-derived mono-unsaturated free fatty acid that potentially serves as a lipokine in metabolic and inflammatory diseases. The aim of this study was to investigate the significance of PO levels in the serum of patients with UC and CD. The study included patients with UC (n = 22), patients with CD (n = 35), and controls (n = 22). The levels of serum PO were analyzed using gas chromatography. The association of serum PO levels with the clinical features and disease outcomes in IBD was examined. Serum PO levels were significantly higher in patients with CD than in controls, whereas no difference in these levels was observed between patients with UC and controls. Serum PO levels were significantly associated with the CD activity index. Additionally, high serum PO levels were associated with an increased risk of surgical intervention requirement during follow-up. In a pilot study with a few patients, high PO levels were observed in the mesenteric tissue in the active disease site of patients with CD (n = 7) compared with those with colon cancer (n = 6). Elevated serum PO levels might serve as a marker for local inflammation and prognosis in patients with CD.Yuko AkazawaTomohito MorisakiHiroko FukudaKiyuu NorimatsuJunya ShiotaKeiichi HashiguchiMaiko TabuchiMoto KitayamaKayoko MatsushimaNaoyuki YamaguchiHisayoshi KondoFumihiko FujitaHiroaki TakeshitaKazuhiko NakaoFuminao TakeshimaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuko Akazawa Tomohito Morisaki Hiroko Fukuda Kiyuu Norimatsu Junya Shiota Keiichi Hashiguchi Maiko Tabuchi Moto Kitayama Kayoko Matsushima Naoyuki Yamaguchi Hisayoshi Kondo Fumihiko Fujita Hiroaki Takeshita Kazuhiko Nakao Fuminao Takeshima Significance of serum palmitoleic acid levels in inflammatory bowel disease
description	Abstract Inflammatory bowel diseases (IBDs), including ulcerative colitis (UC) and Crohn’s disease (CD), are chronic intestinal diseases of unknown etiology that present with variable disease extents and outcomes. The use of biomarkers for the diagnosis and management of IBDs is considered beneficial. Palmitoleic acid (PO) is an adipose tissue-derived mono-unsaturated free fatty acid that potentially serves as a lipokine in metabolic and inflammatory diseases. The aim of this study was to investigate the significance of PO levels in the serum of patients with UC and CD. The study included patients with UC (n = 22), patients with CD (n = 35), and controls (n = 22). The levels of serum PO were analyzed using gas chromatography. The association of serum PO levels with the clinical features and disease outcomes in IBD was examined. Serum PO levels were significantly higher in patients with CD than in controls, whereas no difference in these levels was observed between patients with UC and controls. Serum PO levels were significantly associated with the CD activity index. Additionally, high serum PO levels were associated with an increased risk of surgical intervention requirement during follow-up. In a pilot study with a few patients, high PO levels were observed in the mesenteric tissue in the active disease site of patients with CD (n = 7) compared with those with colon cancer (n = 6). Elevated serum PO levels might serve as a marker for local inflammation and prognosis in patients with CD.
format	article
author	Yuko Akazawa Tomohito Morisaki Hiroko Fukuda Kiyuu Norimatsu Junya Shiota Keiichi Hashiguchi Maiko Tabuchi Moto Kitayama Kayoko Matsushima Naoyuki Yamaguchi Hisayoshi Kondo Fumihiko Fujita Hiroaki Takeshita Kazuhiko Nakao Fuminao Takeshima
author_facet	Yuko Akazawa Tomohito Morisaki Hiroko Fukuda Kiyuu Norimatsu Junya Shiota Keiichi Hashiguchi Maiko Tabuchi Moto Kitayama Kayoko Matsushima Naoyuki Yamaguchi Hisayoshi Kondo Fumihiko Fujita Hiroaki Takeshita Kazuhiko Nakao Fuminao Takeshima
author_sort	Yuko Akazawa
title	Significance of serum palmitoleic acid levels in inflammatory bowel disease
title_short	Significance of serum palmitoleic acid levels in inflammatory bowel disease
title_full	Significance of serum palmitoleic acid levels in inflammatory bowel disease
title_fullStr	Significance of serum palmitoleic acid levels in inflammatory bowel disease
title_full_unstemmed	Significance of serum palmitoleic acid levels in inflammatory bowel disease
title_sort	significance of serum palmitoleic acid levels in inflammatory bowel disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/42922ebd13cf49c5b22a376a5d63310e
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Significance of serum palmitoleic acid levels in inflammatory bowel disease

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