NEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation

NEK1 mutations promote lethality early in life and ALS late in life via unknown mechanisms. Here, the authors show that NEK1 mutation disrupts retromer-mediated trafficking and promotes RIPK1 activation, connecting retromer trafficking and metabolism to neuroinflammation by dietary intervention.

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Autores principales:	Huibing Wang, Weiwei Qi, Chengyu Zou, Zhangdan Xie, Mengmeng Zhang, Masanori Gomi Naito, Lauren Mifflin, Zhen Liu, Ayaz Najafov, Heling Pan, Bing Shan, Ying Li, Zheng-Jiang Zhu, Junying Yuan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4294aac17a8b4f399739cdbf82ea2a17
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spelling	oai:doaj.org-article:4294aac17a8b4f399739cdbf82ea2a172021-12-02T19:06:33ZNEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation10.1038/s41467-021-25157-72041-1723https://doaj.org/article/4294aac17a8b4f399739cdbf82ea2a172021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25157-7https://doaj.org/toc/2041-1723NEK1 mutations promote lethality early in life and ALS late in life via unknown mechanisms. Here, the authors show that NEK1 mutation disrupts retromer-mediated trafficking and promotes RIPK1 activation, connecting retromer trafficking and metabolism to neuroinflammation by dietary intervention.Huibing WangWeiwei QiChengyu ZouZhangdan XieMengmeng ZhangMasanori Gomi NaitoLauren MifflinZhen LiuAyaz NajafovHeling PanBing ShanYing LiZheng-Jiang ZhuJunying YuanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huibing Wang Weiwei Qi Chengyu Zou Zhangdan Xie Mengmeng Zhang Masanori Gomi Naito Lauren Mifflin Zhen Liu Ayaz Najafov Heling Pan Bing Shan Ying Li Zheng-Jiang Zhu Junying Yuan NEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation
description	NEK1 mutations promote lethality early in life and ALS late in life via unknown mechanisms. Here, the authors show that NEK1 mutation disrupts retromer-mediated trafficking and promotes RIPK1 activation, connecting retromer trafficking and metabolism to neuroinflammation by dietary intervention.
format	article
author	Huibing Wang Weiwei Qi Chengyu Zou Zhangdan Xie Mengmeng Zhang Masanori Gomi Naito Lauren Mifflin Zhen Liu Ayaz Najafov Heling Pan Bing Shan Ying Li Zheng-Jiang Zhu Junying Yuan
author_facet	Huibing Wang Weiwei Qi Chengyu Zou Zhangdan Xie Mengmeng Zhang Masanori Gomi Naito Lauren Mifflin Zhen Liu Ayaz Najafov Heling Pan Bing Shan Ying Li Zheng-Jiang Zhu Junying Yuan
author_sort	Huibing Wang
title	NEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation
title_short	NEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation
title_full	NEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation
title_fullStr	NEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation
title_full_unstemmed	NEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation
title_sort	nek1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and ripk1 activation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4294aac17a8b4f399739cdbf82ea2a17
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NEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation

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