Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness.
Metabolite concentrations reflect the physiological states of tissues and cells. However, the role of metabolic changes in species evolution is currently unknown. Here, we present a study of metabolome evolution conducted in three brain regions and two non-neural tissues from humans, chimpanzees, ma...
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2014
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oai:doaj.org-article:4294d9d81a4340dc9cca25bf216fe7a82021-11-11T05:37:09ZExceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness.1544-91731545-788510.1371/journal.pbio.1001871https://doaj.org/article/4294d9d81a4340dc9cca25bf216fe7a82014-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24866127/pdf/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Metabolite concentrations reflect the physiological states of tissues and cells. However, the role of metabolic changes in species evolution is currently unknown. Here, we present a study of metabolome evolution conducted in three brain regions and two non-neural tissues from humans, chimpanzees, macaque monkeys, and mice based on over 10,000 hydrophilic compounds. While chimpanzee, macaque, and mouse metabolomes diverge following the genetic distances among species, we detect remarkable acceleration of metabolome evolution in human prefrontal cortex and skeletal muscle affecting neural and energy metabolism pathways. These metabolic changes could not be attributed to environmental conditions and were confirmed against the expression of their corresponding enzymes. We further conducted muscle strength tests in humans, chimpanzees, and macaques. The results suggest that, while humans are characterized by superior cognition, their muscular performance might be markedly inferior to that of chimpanzees and macaque monkeys.Katarzyna BozekYuning WeiZheng YanXiling LiuJieyi XiongMasahiro SugimotoMasaru TomitaSvante PääboRaik PieszekChet C SherwoodPatrick R HofJohn J ElyDirk SteinhauserLothar WillmitzerJens BangsboOla HanssonJosep CallPatrick GiavaliscoPhilipp KhaitovichPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 12, Iss 5, p e1001871 (2014) |
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DOAJ |
| collection |
DOAJ |
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EN |
| topic |
Biology (General) QH301-705.5 |
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Biology (General) QH301-705.5 Katarzyna Bozek Yuning Wei Zheng Yan Xiling Liu Jieyi Xiong Masahiro Sugimoto Masaru Tomita Svante Pääbo Raik Pieszek Chet C Sherwood Patrick R Hof John J Ely Dirk Steinhauser Lothar Willmitzer Jens Bangsbo Ola Hansson Josep Call Patrick Giavalisco Philipp Khaitovich Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness. |
| description |
Metabolite concentrations reflect the physiological states of tissues and cells. However, the role of metabolic changes in species evolution is currently unknown. Here, we present a study of metabolome evolution conducted in three brain regions and two non-neural tissues from humans, chimpanzees, macaque monkeys, and mice based on over 10,000 hydrophilic compounds. While chimpanzee, macaque, and mouse metabolomes diverge following the genetic distances among species, we detect remarkable acceleration of metabolome evolution in human prefrontal cortex and skeletal muscle affecting neural and energy metabolism pathways. These metabolic changes could not be attributed to environmental conditions and were confirmed against the expression of their corresponding enzymes. We further conducted muscle strength tests in humans, chimpanzees, and macaques. The results suggest that, while humans are characterized by superior cognition, their muscular performance might be markedly inferior to that of chimpanzees and macaque monkeys. |
| format |
article |
| author |
Katarzyna Bozek Yuning Wei Zheng Yan Xiling Liu Jieyi Xiong Masahiro Sugimoto Masaru Tomita Svante Pääbo Raik Pieszek Chet C Sherwood Patrick R Hof John J Ely Dirk Steinhauser Lothar Willmitzer Jens Bangsbo Ola Hansson Josep Call Patrick Giavalisco Philipp Khaitovich |
| author_facet |
Katarzyna Bozek Yuning Wei Zheng Yan Xiling Liu Jieyi Xiong Masahiro Sugimoto Masaru Tomita Svante Pääbo Raik Pieszek Chet C Sherwood Patrick R Hof John J Ely Dirk Steinhauser Lothar Willmitzer Jens Bangsbo Ola Hansson Josep Call Patrick Giavalisco Philipp Khaitovich |
| author_sort |
Katarzyna Bozek |
| title |
Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness. |
| title_short |
Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness. |
| title_full |
Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness. |
| title_fullStr |
Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness. |
| title_full_unstemmed |
Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness. |
| title_sort |
exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2014 |
| url |
https://doaj.org/article/4294d9d81a4340dc9cca25bf216fe7a8 |
| work_keys_str_mv |
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